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A8AYY7 (UPPP_STRGC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:SGO_1725
OrganismStreptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288) [Complete proteome] [HAMAP]
Taxonomic identifier29390 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 282282Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000083995

Regions

Transmembrane45 – 6521Helical; Potential
Transmembrane86 – 10621Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane196 – 21621Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane256 – 27621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A8AYY7 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: E0698B417C1C9528

FASTA28231,836
        10         20         30         40         50         60 
MFFIEIIKSV IFGIIEGITE WLPISSTGHL ILVQEFIHYQ KQNAAFMEMF NVVIQLGAIL 

        70         80         90        100        110        120 
AVVFIYFDKL NPFKPDKTPR QVQKTWQLWA KVVVASLPAV IIGIPLDNWF EKNFHNFVSV 

       130        140        150        160        170        180 
AIMLIIYGIA FILIERRNQE VEPTVTNLEK LPYKTALYIG FFQVLSLFPG TSRSGATIVG 

       190        200        210        220        230        240 
GLLNGTSRSV VTEFTFFLGI PVMFGASGIK VLKFILKGNS LDLGQLTLLL VAMIVAFGVS 

       250        260        270        280 
MYVIRFLTDY VKKHDFTVFG KYRIGLGALL LIYWVFKALF AK 

« Hide

References

[1]"Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide."
Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.
J. Bacteriol. 189:7799-7807(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Challis / ATCC 35105 / CH1 / DL1 / V288.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000725 Genomic DNA. Translation: ABV10913.1.
RefSeqYP_001450997.1. NC_009785.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING467705.SGO_1725.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV10913; ABV10913; SGO_1725.
GeneID5598405.
KEGGsgo:SGO_1725.
PATRIC19661396. VBIStrGor124371_1694.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycSGOR467705:GH3R-1724-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_STRGC
AccessionPrimary (citable) accession number: A8AYY7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families