A8AYY7 (UPPP_STRGC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	SGO_1725

Organism

Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288) [Complete proteome] [HAMAP]

Taxonomic identifier

29390 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus gordonii

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 282	282	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_1000083995
Regions
	Transmembrane	45 – 65	21	Helical; Potential
	Transmembrane	86 – 106	21	Helical; Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Transmembrane	151 – 171	21	Helical; Potential
	Transmembrane	196 – 216	21	Helical; Potential
	Transmembrane	224 – 244	21	Helical; Potential
	Transmembrane	256 – 276	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A8AYY7 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: E0698B417C1C9528	FASTA	282	31,836
	10 20 30 40 50 60 MFFIEIIKSV IFGIIEGITE WLPISSTGHL ILVQEFIHYQ KQNAAFMEMF NVVIQLGAIL 70 80 90 100 110 120 AVVFIYFDKL NPFKPDKTPR QVQKTWQLWA KVVVASLPAV IIGIPLDNWF EKNFHNFVSV 130 140 150 160 170 180 AIMLIIYGIA FILIERRNQE VEPTVTNLEK LPYKTALYIG FFQVLSLFPG TSRSGATIVG 190 200 210 220 230 240 GLLNGTSRSV VTEFTFFLGI PVMFGASGIK VLKFILKGNS LDLGQLTLLL VAMIVAFGVS 250 260 270 280 MYVIRFLTDY VKKHDFTVFG KYRIGLGALL LIYWVFKALF AK

References

[1]

"Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide." Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R. J. Bacteriol. 189:7799-7807(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Challis / ATCC 35105 / CH1 / DL1 / V288.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000725 Genomic DNA. Translation: ABV10913.1.
RefSeq	YP_001450997.1. NC_009785.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	467705.SGO_1725.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABV10913; ABV10913; SGO_1725.
GeneID	5598405.
KEGG	sgo:SGO_1725.
PATRIC	19661396. VBIStrGor124371_1694.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	NDWLDKH.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	SGOR467705:GH3R-1724-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP_STRGC

Accession

Primary (citable) accession number: A8AYY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	October 23, 2007
Last modified:	May 29, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program