A8AYW5 (FABH_STRGC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
EC=2.3.1.180

Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III
Beta-ketoacyl-ACP synthase III
Short name=KAS III

Gene names

Name:	fabH
Ordered Locus Names:	SGO_1698

Organism

Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288) [Complete proteome] [HAMAP]

Taxonomic identifier

29390 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815
Catalytic activity	Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815
Pathway	Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815
Subunit structure	Homodimer By similarity. HAMAP MF_01815
Subcellular location	Cytoplasm Probable HAMAP MF_01815.
Domain	The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815
Sequence similarities	Belongs to the FabH family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-oxoacyl-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: InterPro beta-ketoacyl-acyl-carrier-protein synthase III activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 324	324	3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815		PRO_1000088327
Regions
	Region	250 – 254	5	ACP-binding By similarity
Sites
	Active site	112	1	By similarity
	Active site	249	1	By similarity
	Active site	279	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8AYW5 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 8557830D1C1817D3	FASTA	324	34,987
	10 20 30 40 50 60 MKFAKISQVA HYAPEQVVTN DDLAQIMDTS DEWISSRTGI KKRHISHHES TSDLATRVAL 70 80 90 100 110 120 DLLKKSEISA QDLDFIIVAT ITPDSLMPST AARVQANIGA KKAFAYDLVA ACSGFVFALS 130 140 150 160 170 180 TAEKLISSGA YQKGLVIGSE TLSKVVDWSD RGTAVLFGDG AGGVLLESTS DQHFLAEIQK 190 200 210 220 230 240 TDGSRGESLT SCLMGLQSPF AQTEDDEKYL TMDGRAIFDF AIRDVAQSIK DTIEASPLEV 250 260 270 280 290 300 DEIDYFLLHQ ANDRILNKIA KKLSVSRDKI PANMMEYGNT SAASIPILLS ECVEQGLVKL 310 320 DGSQKILLSG FGGGLTWGTL IVTI

References

[1]

"Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide." Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R. J. Bacteriol. 189:7799-7807(2007) [PubMed: 17720781] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Challis / ATCC 35105 / CH1 / DL1 / V288.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000725 Genomic DNA. Translation: ABV10797.1.
RefSeq	YP_001450975.1. NC_009785.1.
3D structure databases
ProteinModelPortal	A8AYW5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000010449; EBSTRP00000010006; EBSTRG00000010449.
GeneID	5598845.
GenomeReviews	Gene locus SGO_1698 in contig CP000725_GR.
KEGG	sgo:SGO_1698.
PATRIC	19661344. VBIStrGor124371_1673.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027516.
HOGENOM	HBG649927.
OMA	HISHHES.
ProtClustDB	PRK09352.
Enzyme and pathway databases
BioCyc	SGOR29390:SGO_1698-MONOMER.
Family and domain databases
HAMAP	MF_01815. FabH. [Tree]
InterPro	IPR013751. ACP_syn_III. IPR013747. ACP_syn_III_C. IPR004655. FabH_synth. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KO	K00648.
Pfam	PF08545. ACP_syn_III. 1 hit. PF08541. ACP_syn_III_C. 1 hit. [Graphical view]
SUPFAM	SSF53901. Thiolase-like. 1 hit.
TIGRFAMs	TIGR00747. FabH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FABH_STRGC

Accession

Primary (citable) accession number: A8AYW5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	October 23, 2007
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program