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A8AY25 (A8AY25_STRGC) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase RuleBase RU003658 HAMAP-Rule MF_01014
EC=5.3.1.16 RuleBase RU003658 HAMAP-Rule MF_01014
Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HAMAP-Rule MF_01014
Gene names
Name:hisA HAMAP-Rule MF_01014
Ordered Locus Names:SGO_1405
OrganismStreptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288) [Complete proteome] [HAMAP]
Taxonomic identifier29390 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide. RuleBase RU003658 HAMAP-Rule MF_01014 SAAS SAAS006063

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. RuleBase RU003658 HAMAP-Rule MF_01014 SAAS SAAS006063

Subcellular location

Cytoplasm By similarity RuleBase RU003658 HAMAP-Rule MF_01014 SAAS SAAS006063.

Sequence similarities

Belongs to the HisA/HisF family. RuleBase RU003657 HAMAP-Rule MF_01014

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site81Proton acceptor By similarity HAMAP-Rule MF_01014
Active site1301Proton donor By similarity HAMAP-Rule MF_01014

Sequences

Sequence LengthMass (Da)Tools
A8AY25 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: F0E11EC3C627A731

FASTA24025,915
        10         20         30         40         50         60 
MKILPAIDIK DGQAVRLFKG DFSQKTVVNP DVLEQARLFK EVGVTMIHVV DLDGALEGRA 

        70         80         90        100        110        120 
ANRDLIAQIK AETGLAIQVG GGIRSLEQIK DYLAVGIDRV IIGSMAVKNP EFVRAALERF 

       130        140        150        160        170        180 
GSSKIVIGID AKEGLVATEG WLETSNQNYI SLALAMEKIG VRLFVYTDVD RDGTLTGPNI 

       190        200        210        220        230        240 
QHYQKLLASL KHAQVIASGG IQSADDLEEL KKLGLAGAIV GKAYYSGRIS LNQIKEAERG

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References

[1]"Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide."
Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.
J. Bacteriol. 189:7799-7807(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Challis / ATCC 35105 / CH1 / DL1 / V288.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000725 Genomic DNA. Translation: ABV10323.1.
RefSeqYP_001450685.1. NC_009785.1.

3D structure databases

ProteinModelPortalA8AY25.
ModBaseSearch...

Protein-protein interaction databases

STRING467705.SGO_1405.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV10323; ABV10323; SGO_1405.
GeneID5597928.
KEGGsgo:SGO_1405.
PATRIC19660762. VBIStrGor124371_1382.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000224614.
KOK01814.
OMADGHCVRL.
ProtClustDBPRK00748.

Enzyme and pathway databases

BioCycSGOR467705:GH3R-1455-MONOMER.
UniPathwayUPA00031; UER00009.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01014. HisA.
InterProIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR006063. HisA.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMSSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMsTIGR00007. TIGR00007. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA8AY25_STRGC
AccessionPrimary (citable) accession number: A8AY25
Entry history
Integrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info