A8AXZ6 (AROD_STRGC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	SGO_1375

Organism

Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288) [Complete proteome] [HAMAP]

Taxonomic identifier

29390 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_1000078051
Sites
	Active site	118	1	Proton acceptor By similarity
	Active site	143	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8AXZ6 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 4370521B912359A8	FASTA	225	25,730
	10 20 30 40 50 60 MKLVVSVTPR NLEEAQQIDA QRFVDADLIE WRADFLEKEE ILKVAPAIFE KFAGRELIFT 70 80 90 100 110 120 LRTKDEGGHI QLSDDEYVEM IKKVAQLYQP DYVDFEYFSH KDKIDEMLEF PNLVLSYHNF 130 140 150 160 170 180 EETPENMMEI LSELTSLTPK AVKVSVMANS GQDVLDLMNY TRGFKTLNPE QEYVTISMGR 190 200 210 220 VGRISRIASD LTGSSWSFAS LDEATAPGQI SLSSMKKIRD ILNEN

References

[1]

"Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide." Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R. J. Bacteriol. 189:7799-7807(2007) [PubMed: 17720781] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Challis / ATCC 35105 / CH1 / DL1 / V288.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000725 Genomic DNA. Translation: ABV10967.1.
RefSeq	YP_001450656.1. NC_009785.1.
3D structure databases
ProteinModelPortal	A8AXZ6.
SMR	A8AXZ6. Positions 1-222.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000011547; EBSTRP00000011104; EBSTRG00000011547.
GeneID	5599323.
GenomeReviews	Gene locus SGO_1375 in contig CP000725_GR.
KEGG	sgo:SGO_1375.
PATRIC	19660702. VBIStrGor124371_1353.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027890.
HOGENOM	HBG732926.
OMA	VARRTVI.
ProtClustDB	PRK02412.
Enzyme and pathway databases
BioCyc	SGOR29390:SGO_1375-MONOMER.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. AroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_STRGC

Accession

Primary (citable) accession number: A8AXZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	October 23, 2007
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program