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Protein

Purine nucleoside phosphorylase DeoD-type

Gene

deoD

Organism
Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation
Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei4 – 41Purine nucleoside; shared with dimeric partnerBy similarity
Binding sitei20 – 201Phosphate; via amide nitrogenBy similarity
Binding sitei24 – 241PhosphateBy similarity
Binding sitei43 – 431Phosphate; shared with dimeric partnerBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciSGOR467705:GH3R-1258-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylase DeoD-typeUniRule annotation (EC:2.4.2.1UniRule annotation)
Short name:
PNPUniRule annotation
Gene namesi
Name:deoDUniRule annotation
Ordered Locus Names:SGO_1260
OrganismiStreptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
Taxonomic identifieri467705 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001131 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Purine nucleoside phosphorylase DeoD-typePRO_1000186224Add
BLAST

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi467705.SGO_1260.

Structurei

3D structure databases

ProteinModelPortaliA8AXN4.
SMRiA8AXN4. Positions 1-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni87 – 904Phosphate bindingBy similarity
Regioni179 – 1813Purine nucleoside bindingBy similarity
Regioni203 – 2042Purine nucleoside bindingBy similarity

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D3A. Bacteria.
COG0813. LUCA.
HOGENOMiHOG000274896.
KOiK03784.
OMAiPQCLLCG.
OrthoDBiEOG6BKJC5.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01627. Pur_nucleosid_phosp.
InterProiIPR004402. DeoD-type.
IPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR00107. deoD. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8AXN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIHIAAQQG EIADKILLPG DPLRAKFIAE NFLEDAVCFN EVRNMFGYTG
60 70 80 90 100
TYKGHRVSVM GTGMGMPSIS IYARELIVDY GVKKLIRVGT AGSLNEDVHV
110 120 130 140 150
RELVLAQAAA TNSNIIRNDW PQYDFPQIAS FDLLDKAYHI AKDLGMTTHV
160 170 180 190 200
GNVLSSDVFY SNYFEKNIEL GKWGVKAVEM EAAALYYLAA QHHVDALAIM
210 220 230
TISDSLVNPE EDTTAEERQN TFTDMMKVGL ETLIAEA
Length:237
Mass (Da):26,243
Last modified:October 23, 2007 - v1
Checksum:iA866546231F843BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000725 Genomic DNA. Translation: ABV10410.1.
RefSeqiWP_012000655.1. NC_009785.1.

Genome annotation databases

EnsemblBacteriaiABV10410; ABV10410; SGO_1260.
GeneIDi25051210.
KEGGisgo:SGO_1260.
PATRICi19660473. VBIStrGor124371_1240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000725 Genomic DNA. Translation: ABV10410.1.
RefSeqiWP_012000655.1. NC_009785.1.

3D structure databases

ProteinModelPortaliA8AXN4.
SMRiA8AXN4. Positions 1-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi467705.SGO_1260.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV10410; ABV10410; SGO_1260.
GeneIDi25051210.
KEGGisgo:SGO_1260.
PATRICi19660473. VBIStrGor124371_1240.

Phylogenomic databases

eggNOGiENOG4105D3A. Bacteria.
COG0813. LUCA.
HOGENOMiHOG000274896.
KOiK03784.
OMAiPQCLLCG.
OrthoDBiEOG6BKJC5.

Enzyme and pathway databases

BioCyciSGOR467705:GH3R-1258-MONOMER.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01627. Pur_nucleosid_phosp.
InterProiIPR004402. DeoD-type.
IPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR00107. deoD. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide."
    Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.
    J. Bacteriol. 189:7799-7807(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288.

Entry informationi

Entry nameiDEOD_STRGC
AccessioniPrimary (citable) accession number: A8AXN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: October 23, 2007
Last modified: July 6, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.