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A8AXM8

- PYRF_STRGC

UniProt

A8AXM8 - PYRF_STRGC

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111SubstrateUniRule annotation
Binding sitei34 – 341SubstrateUniRule annotation
Active sitei63 – 631Proton donorUniRule annotation
Binding sitei117 – 1171SubstrateUniRule annotation
Binding sitei179 – 1791SubstrateUniRule annotation
Binding sitei188 – 1881SubstrateUniRule annotation
Binding sitei208 – 2081Substrate; via amide nitrogenUniRule annotation
Binding sitei209 – 2091SubstrateUniRule annotation

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciSGOR467705:GH3R-1252-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:SGO_1254
OrganismiStreptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288)
Taxonomic identifieri29390 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001131: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Orotidine 5'-phosphate decarboxylasePRO_1000085496Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi467705.SGO_1254.

Structurei

3D structure databases

ProteinModelPortaliA8AXM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni61 – 7010Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226071.
KOiK01591.
OMAiSAYHAIK.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8AXM8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MREERPIIAL DFPSFDDVKA FLEHFPEDEK LFVKIGMEFF YAIGPEIVHY
60 70 80 90 100
LKGLGHSIFL DLKLHDIPNT VRSAMSVLGT FGIDMVTVHA AGGVEMMSEA
110 120 130 140 150
KKVLGDKAKL VAVTQLTSTS EEDMRDCQNI QTTVQESVVN YARKAKEAGL
160 170 180 190 200
DGVVCSAQEV ELIKAATAED FLCVTPGIRP AGSEIGDQKR VMTPQEAHQI
210 220 230
GSDYIVVGRP IIQAENPWDA YHEIKKQWNS
Length:230
Mass (Da):25,495
Last modified:October 23, 2007 - v1
Checksum:iDCFF9844C8F4E0C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000725 Genomic DNA. Translation: ABV10863.1.
RefSeqiYP_001450538.1. NC_009785.1.

Genome annotation databases

EnsemblBacteriaiABV10863; ABV10863; SGO_1254.
GeneIDi5599184.
KEGGisgo:SGO_1254.
PATRICi19660461. VBIStrGor124371_1234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000725 Genomic DNA. Translation: ABV10863.1 .
RefSeqi YP_001450538.1. NC_009785.1.

3D structure databases

ProteinModelPortali A8AXM8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 467705.SGO_1254.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV10863 ; ABV10863 ; SGO_1254 .
GeneIDi 5599184.
KEGGi sgo:SGO_1254.
PATRICi 19660461. VBIStrGor124371_1234.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226071.
KOi K01591.
OMAi SAYHAIK.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci SGOR467705:GH3R-1252-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide."
    Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.
    J. Bacteriol. 189:7799-7807(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Challis / ATCC 35105 / CH1 / DL1 / V288.

Entry informationi

Entry nameiPYRF_STRGC
AccessioniPrimary (citable) accession number: A8AXM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3