A8AXK8 (A8AXK8_STRGC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP-Rule MF_01897
EC=5.99.1.3 HAMAP-Rule MF_01897

Gene names

Name:	gyrA HAMAP-Rule MF_01897
Ordered Locus Names:	SGO_1231

Organism

Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288) [Complete proteome] [HAMAP]

Taxonomic identifier

29390 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus gordonii

Protein attributes

Sequence length	817 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743
Subunit structure	Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP-Rule MF_01897
Ligand	ATP-binding HAMAP-Rule MF_01897 SAAS SAAS013760 DNA-binding SAAS SAAS005743 HAMAP-Rule MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS005743 HAMAP-Rule MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP
Cellular_component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase type II (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	120	1	O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

	Sequence		Length	Mass (Da)
	A8AXK8 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 5CD5449F8C79653F	FASTA	817	91,499
	10 20 30 40 50 60 MQDKNLVNVN LTSEMKTSFI DYAMSVIVSR ALPDVRDGLK PVHRRILYGM NELGVTPDKP 70 80 90 100 110 120 HKKSARITGD VMGKYHPHGD SSIYEAMVRM AQWWSYRYML VDGHGNFGSM DGDGAAAQRY 130 140 150 160 170 180 TEARMSKIAL EMLRDINKNT VDFIDNYDAN EREPIVLPAR FPNLLVNGAT GIAVGMATNI 190 200 210 220 230 240 PPHNLAESID AVKLVMDNPE ATTRDIMEVL PGPDFPTGAL VMGKSGIHRA YETGKGSIVL 250 260 270 280 290 300 RSRTEIEEMK NGRERIVVTE FPYMVNKTKV HEHIVRLVQE KRIDGITAVR DESNREGVRF 310 320 330 340 350 360 VIEVRRDASA HVILNNLFKL TQMQTNFSFN MLAIQNGVPK ILSLREILLA YIEHQKEVVT 370 380 390 400 410 420 RRTAFDKDKA EARAHILAGL LIALDHIDEV IRIIRNSETD AEAQAELMAK FELSERQSQA 430 440 450 460 470 480 ILDMRLRRLT GLERDKIQSE YDELIALIAD LADILAKPER VLTIIREELD EVKRKFADER 490 500 510 520 530 540 RTELMVGEVL SLEDEDLIEE ADVLITLSNK GYIKRLNQDE FTAQKRGGRG VQGTGVKDDD 550 560 570 580 590 600 FVKELVSTST HDRLLFFTNK GRVYRLKGYE IPEYGRTAKG LPIVNLLKLD EGETIQTIIN 610 620 630 640 650 660 VEQDHSQDSY LFFTTRLGVV KRTSVADFAN IRQNGLKALN LKDEDELINV FLTDGAADVI 670 680 690 700 710 720 IGTKFGYSVR FNETAVRNMS RIATGVRGVN LRDGDQVVGA GVVSDNDEVL VITEKGYGKR 730 740 750 760 770 780 TLASEYPTKG RGGKGIKTAN ITEKNGPLAG LMTVNGQEDL MIITNTGVII RTSVANISQT 790 800 810 GRSTMGVKVM RLDQNAQIVT FTTVEADDKE ELQDEKE

References

[1]

"Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide." Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R. J. Bacteriol. 189:7799-7807(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Challis / ATCC 35105 / CH1 / DL1 / V288.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000725 Genomic DNA. Translation: ABV10548.1.
RefSeq	YP_001450518.1. NC_009785.1.
3D structure databases
ProteinModelPortal	A8AXK8.
SMR	A8AXK8. Positions 28-484.
ModBase	Search...
Protein-protein interaction databases
STRING	467705.SGO_1231.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABV10548; ABV10548; SGO_1231.
GeneID	5598349.
KEGG	sgo:SGO_1231.
PATRIC	19660413. VBIStrGor124371_1213.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000076279.
KO	K02469.
OMA	IAQEDVV.
ProtClustDB	PRK05560.
Enzyme and pathway databases
BioCyc	SGOR467705:GH3R-1287-MONOMER.
Family and domain databases
Gene3D	3.30.1360.40. 1 hit. 3.90.199.10. 2 hits.
HAMAP	MF_01897. GyrA.
InterPro	IPR024946. Arg_repress_C-like. IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013760. Topo_IIA_like_dom. [Graphical view]
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. gyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A8AXK8_STRGC

Accession

Primary (citable) accession number: A8AXK8

Entry history

Integrated into UniProtKB/TrEMBL:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)