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Protein

NAD kinase

Gene

nadK

Organism
Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei50Proton acceptorUniRule annotation1
Binding sitei152NADUniRule annotation1
Binding sitei154NADUniRule annotation1
Binding sitei189NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi50 – 51NADUniRule annotation2
Nucleotide bindingi126 – 127NADUniRule annotation2
Nucleotide bindingi165 – 170NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:SGO_1221
OrganismiStreptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
Taxonomic identifieri467705 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001131 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000795251 – 274NAD kinaseAdd BLAST274

Proteomic databases

PRIDEiA8AXJ8

Interactioni

Protein-protein interaction databases

STRINGi467705.SGO_1221

Structurei

3D structure databases

ProteinModelPortaliA8AXJ8
SMRiA8AXJ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000275803
KOiK00858
OMAiNGIERMS
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

A8AXJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNTDKKIAV FSNYKPQSKE VCQLLIKKLR QNRFILTDKN PDIVISVGGD
60 70 80 90 100
GMLLSVFHKY EKQLDKVRFV GVHTGHLGFY TDYRDFEIDK LIDNLKLDTG
110 120 130 140 150
AQVSYPILNV RIFLEDGSVK TKLALNEATI KRSDRTMVAD VMINHVAFER
160 170 180 190 200
FRGDGISVST PTGSTAYNKS LGGAVLHPTI EALQIAEVAS LNNRVYRTLG
210 220 230 240 250
SSIIVPKKDK IEIFPTRNDQ HTISVDNRTY TFKHIAKVEF QIDNHKIHFV
260 270
ASPSHTSFWN RVKDAFIGEV DDEI
Length:274
Mass (Da):31,056
Last modified:October 23, 2007 - v1
Checksum:i24203D4B01AC317E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000725 Genomic DNA Translation: ABV09301.1
RefSeqiWP_012000622.1, NC_009785.1

Genome annotation databases

EnsemblBacteriaiABV09301; ABV09301; SGO_1221
GeneIDi25051393
KEGGisgo:SGO_1221

Similar proteinsi

Entry informationi

Entry nameiNADK_STRGC
AccessioniPrimary (citable) accession number: A8AXJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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