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A8AXJ8 (NADK_STRGC) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:SGO_1221
OrganismStreptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288) [Complete proteome] [HAMAP]
Taxonomic identifier29390 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274NAD kinase HAMAP-Rule MF_00361
PRO_1000079525

Regions

Nucleotide binding50 – 512NAD By similarity
Nucleotide binding126 – 1272NAD By similarity
Nucleotide binding165 – 1706NAD By similarity

Sites

Active site501Proton acceptor By similarity
Binding site1521NAD By similarity
Binding site1541NAD By similarity
Binding site1891NAD; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
A8AXJ8 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 24203D4B01AC317E

FASTA27431,056
        10         20         30         40         50         60 
MKNTDKKIAV FSNYKPQSKE VCQLLIKKLR QNRFILTDKN PDIVISVGGD GMLLSVFHKY 

        70         80         90        100        110        120 
EKQLDKVRFV GVHTGHLGFY TDYRDFEIDK LIDNLKLDTG AQVSYPILNV RIFLEDGSVK 

       130        140        150        160        170        180 
TKLALNEATI KRSDRTMVAD VMINHVAFER FRGDGISVST PTGSTAYNKS LGGAVLHPTI 

       190        200        210        220        230        240 
EALQIAEVAS LNNRVYRTLG SSIIVPKKDK IEIFPTRNDQ HTISVDNRTY TFKHIAKVEF 

       250        260        270 
QIDNHKIHFV ASPSHTSFWN RVKDAFIGEV DDEI 

« Hide

References

[1]"Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide."
Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.
J. Bacteriol. 189:7799-7807(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Challis / ATCC 35105 / CH1 / DL1 / V288.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000725 Genomic DNA. Translation: ABV09301.1.
RefSeqYP_001450508.1. NC_009785.1.

3D structure databases

ProteinModelPortalA8AXJ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING467705.SGO_1221.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV09301; ABV09301; SGO_1221.
GeneID5598472.
KEGGsgo:SGO_1221.
PATRIC19660393. VBIStrGor124371_1203.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000275803.
KOK00858.
OMAQWITIVP.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycSGOR467705:GH3R-1219-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_STRGC
AccessionPrimary (citable) accession number: A8AXJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: July 9, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families