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Protein

NAD kinase

Gene

nadK

Organism
Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei50 – 501Proton acceptorUniRule annotation
Binding sitei152 – 1521NADUniRule annotation
Binding sitei154 – 1541NADUniRule annotation
Binding sitei189 – 1891NAD; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi50 – 512NADUniRule annotation
Nucleotide bindingi126 – 1272NADUniRule annotation
Nucleotide bindingi165 – 1706NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciSGOR467705:GH3R-1219-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:SGO_1221
OrganismiStreptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288)
Taxonomic identifieri29390 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001131 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274NAD kinasePRO_1000079525Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi467705.SGO_1221.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000275803.
KOiK00858.
OMAiHRYENQV.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A8AXJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNTDKKIAV FSNYKPQSKE VCQLLIKKLR QNRFILTDKN PDIVISVGGD
60 70 80 90 100
GMLLSVFHKY EKQLDKVRFV GVHTGHLGFY TDYRDFEIDK LIDNLKLDTG
110 120 130 140 150
AQVSYPILNV RIFLEDGSVK TKLALNEATI KRSDRTMVAD VMINHVAFER
160 170 180 190 200
FRGDGISVST PTGSTAYNKS LGGAVLHPTI EALQIAEVAS LNNRVYRTLG
210 220 230 240 250
SSIIVPKKDK IEIFPTRNDQ HTISVDNRTY TFKHIAKVEF QIDNHKIHFV
260 270
ASPSHTSFWN RVKDAFIGEV DDEI
Length:274
Mass (Da):31,056
Last modified:October 22, 2007 - v1
Checksum:i24203D4B01AC317E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000725 Genomic DNA. Translation: ABV09301.1.
RefSeqiYP_001450508.1. NC_009785.1.

Genome annotation databases

EnsemblBacteriaiABV09301; ABV09301; SGO_1221.
KEGGisgo:SGO_1221.
PATRICi19660393. VBIStrGor124371_1203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000725 Genomic DNA. Translation: ABV09301.1.
RefSeqiYP_001450508.1. NC_009785.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi467705.SGO_1221.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV09301; ABV09301; SGO_1221.
KEGGisgo:SGO_1221.
PATRICi19660393. VBIStrGor124371_1203.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000275803.
KOiK00858.
OMAiHRYENQV.
OrthoDBiEOG6PZXDR.

Enzyme and pathway databases

BioCyciSGOR467705:GH3R-1219-MONOMER.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide."
    Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.
    J. Bacteriol. 189:7799-7807(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Challis / ATCC 35105 / CH1 / DL1 / V288.

Entry informationi

Entry nameiNADK_STRGC
AccessioniPrimary (citable) accession number: A8AXJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 19, 2008
Last sequence update: October 22, 2007
Last modified: March 31, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.