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A8AXH0

- TRMFO_STRGC

UniProt

A8AXH0 - TRMFO_STRGC

Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156FADUniRule annotation

    GO - Molecular functioni

    1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
    2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
    3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciSGOR467705:GH3R-1191-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
    Alternative name(s):
    Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
    Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmFOUniRule annotation
    Synonyms:gid
    Ordered Locus Names:SGO_1193
    OrganismiStreptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288)
    Taxonomic identifieri29390 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001131: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 444444Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOPRO_1000084293Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi467705.SGO_1193.

    Structurei

    3D structure databases

    ProteinModelPortaliA8AXH0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1206.
    HOGENOMiHOG000252054.
    KOiK04094.
    OMAiEIYFEGC.
    OrthoDBiEOG6J74VT.

    Family and domain databases

    HAMAPiMF_01037. TrmFO.
    InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    [Graphical view]
    PfamiPF01134. GIDA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
    PROSITEiPS01281. GIDA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8AXH0-1 [UniParc]FASTAAdd to Basket

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    MSQSYINVIG AGLAGSEAAY QIAKRGIPVK LYEMRGVKST PQHKTADFAE    50
    LVCSNSLRGD ALTNAVGLLK EEMRRLDSVI LKSAEATRVP AGGALAVDRE 100
    GFSQMVTELV TNHPLIEVIR EEITEIPNDD ITVIATGPLT SDALAEKIHA 150
    LNGGNGFYFY DAAAPIIDVN TIDMTKIYLK SRYDKGEAAY LNAPMTKQEF 200
    MDFHDALVNA EEAPLNSFEK EKYFEGCMPI EVMAKRGIKT MLYGPMKPVG 250
    LEYPDDYQGP RDGEYKTPYA VVQLRQDNAA GSLYNIVGFQ THLKWGEQKR 300
    VFQMIPGLEN AEFVRYGVMH RNSYMDSPNL LEQTFRSKKQ PNLFFAGQMT 350
    GVEGYVESAA SGLVAGINAA RLFKGEEALV FPETTAIGSL PHYVTHADSK 400
    HFQPMNVNFG IIKELDGPRI RDKKERYEKI AERALQDLAP YLDK 444
    Length:444
    Mass (Da):49,330
    Last modified:October 23, 2007 - v1
    Checksum:i83A40CD27DC2C548
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000725 Genomic DNA. Translation: ABV09583.1.
    RefSeqiYP_001450480.1. NC_009785.1.

    Genome annotation databases

    EnsemblBacteriaiABV09583; ABV09583; SGO_1193.
    GeneIDi5598455.
    KEGGisgo:SGO_1193.
    PATRICi19660339. VBIStrGor124371_1176.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000725 Genomic DNA. Translation: ABV09583.1 .
    RefSeqi YP_001450480.1. NC_009785.1.

    3D structure databases

    ProteinModelPortali A8AXH0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 467705.SGO_1193.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV09583 ; ABV09583 ; SGO_1193 .
    GeneIDi 5598455.
    KEGGi sgo:SGO_1193.
    PATRICi 19660339. VBIStrGor124371_1176.

    Phylogenomic databases

    eggNOGi COG1206.
    HOGENOMi HOG000252054.
    KOi K04094.
    OMAi EIYFEGC.
    OrthoDBi EOG6J74VT.

    Enzyme and pathway databases

    BioCyci SGOR467705:GH3R-1191-MONOMER.

    Family and domain databases

    HAMAPi MF_01037. TrmFO.
    InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    [Graphical view ]
    Pfami PF01134. GIDA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
    PROSITEi PS01281. GIDA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide."
      Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.
      J. Bacteriol. 189:7799-7807(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Challis / ATCC 35105 / CH1 / DL1 / V288.

    Entry informationi

    Entry nameiTRMFO_STRGC
    AccessioniPrimary (citable) accession number: A8AXH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3