A8AX88 (PYRB_STRGC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	SGO_1109

Organism

Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288) [Complete proteome] [HAMAP]

Taxonomic identifier

29390 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_1000073744

Sequences

	Sequence		Length	Mass (Da)
	A8AX88 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: BC79CE287E1D1553	FASTA	306	34,741
	10 20 30 40 50 60 MSSNQIALKN LVSMETLSNE EVMALIKRGI EFKNGAKANY DEQHIVANLF FEPSTRTHKA 70 80 90 100 110 120 FEVAELKLGC DLLDFDVKTS SVNKGETLYD TILTMSALGV DICVIRHPEV DYYKELVESP 130 140 150 160 170 180 TITTSIVNGG DGSGQHPSQS LLDLMTIYQE FGHFEGLKVA IAGDLDHSRV AKSNMQILKR 190 200 210 220 230 240 LGAELYFAGP EEWRSEEFSH YGEFVTIDEV VDKVDVMMFL RVQHERHDYE SIFSKENYHR 250 260 270 280 290 300 LHGLTQERYD RMKDTAILMH PAPVNRDVEI ADHLVEAPKS RIVEQMTNGV FVRMAIIEAV LKGREK

References

[1]

"Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide." Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R. J. Bacteriol. 189:7799-7807(2007) [PubMed: 17720781] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Challis / ATCC 35105 / CH1 / DL1 / V288.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000725 Genomic DNA. Translation: ABV09520.1.
RefSeq	YP_001450398.1. NC_009785.1.
3D structure databases
ProteinModelPortal	A8AX88.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000010464; EBSTRP00000010021; EBSTRG00000010464.
GeneID	5597902.
GenomeReviews	Gene locus SGO_1109 in contig CP000725_GR.
KEGG	sgo:SGO_1109.
PATRIC	19660173. VBIStrGor124371_1093.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027081.
HOGENOM	HBG579429.
OMA	DLYTIRQ.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	SGOR29390:SGO_1109-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_STRGC

Accession

Primary (citable) accession number: A8AX88

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	October 23, 2007
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program