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Protein

UvrABC system protein B

Gene

uvrB

Organism
Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 51ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease, Helicase, Hydrolase
Biological processDNA damage, DNA excision, DNA repair, SOS response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein BUniRule annotation
Short name:
Protein UvrBUniRule annotation
Alternative name(s):
Excinuclease ABC subunit BUniRule annotation
Gene namesi
Name:uvrBUniRule annotation
Ordered Locus Names:SGO_1038
OrganismiStreptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
Taxonomic identifieri467705 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001131 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000779231 – 662UvrABC system protein BAdd BLAST662

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi467705.SGO_1038.

Structurei

3D structure databases

ProteinModelPortaliA8AX17.
SMRiA8AX17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 188Helicase ATP-bindingUniRule annotationAdd BLAST158
Domaini435 – 601Helicase C-terminalUniRule annotationAdd BLAST167
Domaini626 – 661UVRUniRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi97 – 120Beta-hairpinAdd BLAST24

Domaini

The beta-hairpin motif is involved in DNA binding.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCW. Bacteria.
COG0556. LUCA.
HOGENOMiHOG000073580.
KOiK03702.
OMAiRYMHSEI.
OrthoDBiPOG091H02LK.

Family and domain databases

CDDicd00079. HELICc. 1 hit.
Gene3Di4.10.860.10. 1 hit.
HAMAPiMF_00204. UvrB. 1 hit.
InterProiView protein in InterPro
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR036876. UVR_dom_sf.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
PANTHERiPTHR24029. PTHR24029. 1 hit.
PfamiView protein in Pfam
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00631. uvrb. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.

Sequencei

Sequence statusi: Complete.

A8AX17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINRITDNKF ELISKYEPSG DQPQAIEQLV DNIEGGEKAQ ILMGATGTGK
60 70 80 90 100
TYTMSQVIAQ VNKPTLVIAH NKTLAGQLYG EFKEFFPNNA VEYFVSYYDY
110 120 130 140 150
YQPEAYVPSS DTYIEKDSSV NDEIDKLRHS ATSALLERND VIVVASVSCI
160 170 180 190 200
YGLGSPKEYS DSVVSLRPGL EISRDKLLND LVDIQFERND IDFQRGKFRV
210 220 230 240 250
RGDVVEIFPA SRDEHAFRVE FFGDEIDRIR EVEALTGRVL GEVDHLAIFP
260 270 280 290 300
ATHFVTNEDH MEVAIAKIQA ELEEQLAKFE KEGKLLEAQR LKQRTEYDIE
310 320 330 340 350
MLREMGYTNG VENYSRHMDG RSEGEPPYTL LDFFPDDFLI MIDESHMTMG
360 370 380 390 400
QIRGMYNGDR SRKEMLVNYG FRLPSALDNR PLRREEFESH VHQIVYVSAT
410 420 430 440 450
PGDYENEQTD TVIEQIIRPT GLLDPEVEVR PTMGQIDDLL GEINARVEKN
460 470 480 490 500
ERTFITTLTK KMAEDLTDYF KEMGVKVKYM HSDIKTLERT EIIRDLRLGV
510 520 530 540 550
FDVLVGINLL REGIDVPEVS LVAILDADKE GFLRNERGLI QTIGRAARNS
560 570 580 590 600
EGHVIMYADT MTQSMQRAID ETARRRAIQM AYNEEHGIVP QTIKKEIRDL
610 620 630 640 650
ISVTKTALPD KEETVEIESL NKQERKDMIK KLEGQMQEAA GLLDFELAAQ
660
IRDMILEIKA MD
Length:662
Mass (Da):75,695
Last modified:October 23, 2007 - v1
Checksum:iD9620C555B976DFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000725 Genomic DNA. Translation: ABV09195.1.
RefSeqiWP_012000451.1. NC_009785.1.

Genome annotation databases

EnsemblBacteriaiABV09195; ABV09195; SGO_1038.
GeneIDi25052985.
KEGGisgo:SGO_1038.

Similar proteinsi

Entry informationi

Entry nameiUVRB_STRGC
AccessioniPrimary (citable) accession number: A8AX17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: October 25, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families