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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381UniRule annotation
Active sitei610 – 6101UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciSGOR467705:GH3R-759-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:SGO_0760
OrganismiStreptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288)
Taxonomic identifieri29390 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001131: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 948948Phosphoenolpyruvate carboxylasePRO_1000082437Add
BLAST

Proteomic databases

PRIDEiA8AW99.

Interactioni

Protein-protein interaction databases

STRINGi467705.SGO_0760.

Structurei

3D structure databases

ProteinModelPortaliA8AW99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 2 hits.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8AW99-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFNKLESFS NKEVIREEVS ILTDLLTDVT RKILSPETFE KIAMMEDLAV
60 70 80 90 100
HSKYQELKEI VEELTTEEMV YISRYFSILP LLINISEDVD LAYEINHQNN
110 120 130 140 150
IDQDYLGKLS TTIDLISTRE NAKEILENLN VVPVLTAHPT QVQRKTMLDL
160 170 180 190 200
TNHIHTLLRQ HRDVKAGLVN EKKWLGNLRR YIELMMQTDM IRDKKLKVTN
210 220 230 240 250
EITNVMEYYN SSFLQAITNF MVEYKRLAEE RGIKLDNPKP ITMGMWIGGD
260 270 280 290 300
RDGNPFVTAE TLKLSATLQS EVILNYYIDK VYTLYRTFSL STNLSETSQA
310 320 330 340 350
VAEMAALSTD KSVYRENEPY RRAFHYIQSK LIQTLLYLKE GNFSNEGQRL
360 370 380 390 400
TDRAEKTLSA KTTPSLSNKG REIIPNYIQS RISETLTELK KEETPSYKTA
410 420 430 440 450
KEFKEDLQVI YDSLIEHHGE ALVTGDLTEL LQAVDVFGFF LASIDMRQDS
460 470 480 490 500
SVHEACVAEL LASANIVKDY SSLSEEEKCQ VLLKQLLEDP RILSATHEPK
510 520 530 540 550
SELLQKELEI FKTARQLKDA LGEEVIKQNI ISHSTSVSDL LELAIMLKEV
560 570 580 590 600
GLIDENGTRV QIVPLFETIE DLDNSCETME KYLSLPIAQK WIASKNNYQE
610 620 630 640 650
IMLGYSDSNK DGGYLSSCWT LYKAQQQLTA IGDKFGVKIT FFHGRGGTVG
660 670 680 690 700
RGGGPTYEAI TSQPLRSIND RIRLTEQGEV IGNKYGNKDA AYYNLEMLVS
710 720 730 740 750
AAINRMVTHK KSDAHTSNKY ERIMDQVVER SYQIYRDLVF GDERFYDYFF
760 770 780 790 800
ESSPIKAISS FNIGSRPAAR KTITEIGGLR AIPWVFSWSQ SRVMFPGWYG
810 820 830 840 850
VGSSFKEFID QDPENNLAFL QLMYKRWPFF KSLLSNVDMV LSKSNMNIAF
860 870 880 890 900
EYAQLCEDQN VRDIFNIILD EWQLTKNVIL EIEGHDELLA ENTYLRDSLD
910 920 930 940
YRMPYFNVLN YIQLELIKRQ RNGQLTPDQE KLIHITINGI ATGLRNSG
Length:948
Mass (Da):108,837
Last modified:October 23, 2007 - v1
Checksum:i6E585C733AC2DC54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000725 Genomic DNA. Translation: ABV09428.1.
RefSeqiYP_001450059.1. NC_009785.1.

Genome annotation databases

EnsemblBacteriaiABV09428; ABV09428; SGO_0760.
GeneIDi5599235.
KEGGisgo:SGO_0760.
PATRICi19659481. VBIStrGor124371_0747.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000725 Genomic DNA. Translation: ABV09428.1.
RefSeqiYP_001450059.1. NC_009785.1.

3D structure databases

ProteinModelPortaliA8AW99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi467705.SGO_0760.

Proteomic databases

PRIDEiA8AW99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV09428; ABV09428; SGO_0760.
GeneIDi5599235.
KEGGisgo:SGO_0760.
PATRICi19659481. VBIStrGor124371_0747.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciSGOR467705:GH3R-759-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 2 hits.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide."
    Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.
    J. Bacteriol. 189:7799-7807(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Challis / ATCC 35105 / CH1 / DL1 / V288.

Entry informationi

Entry nameiCAPP_STRGC
AccessioniPrimary (citable) accession number: A8AW99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: January 7, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.