A8AW03 (TRPC_STRGC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	SGO_0660

Organism

Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288) [Complete proteome] [HAMAP]

Taxonomic identifier

29390 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000076427

Sequences

	Sequence		Length	Mass (Da)
	A8AW03 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 6F8647EDD407FEF4	FASTA	255	28,669
	10 20 30 40 50 60 MSKEFLPTIL EQKEQEVEAM SYEELQPLRS TYSLYEYLKS QSQELQLIAE VKKASPSLGD 70 80 90 100 110 120 INLAVDIVEQ ARTYERCGAA MISVLTDEIF FKGHLDYLRE ISSQVSIPTL NKDFIIDEKQ 130 140 150 160 170 180 IVRARNAGAT IILLIVAALS EKRLQELYDF ATGLGLEVLV ETHNLAELET AHRIGARIIG 190 200 210 220 230 240 VNNRNLVTFE TDINTSLQLS AHFKDDRVYV SESAIFSKED AEQVAPYFHA ILVGTALMQA 250 EDVAEKIKEL KIDKG

References

[1]

"Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide." Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R. J. Bacteriol. 189:7799-7807(2007) [PubMed: 17720781] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Challis / ATCC 35105 / CH1 / DL1 / V288.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000725 Genomic DNA. Translation: ABV10029.1.
RefSeq	YP_001449963.1. NC_009785.1.
3D structure databases
ProteinModelPortal	A8AW03.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000012228; EBSTRP00000011785; EBSTRG00000012228.
GeneID	5597876.
GenomeReviews	Gene locus SGO_0660 in contig CP000725_GR.
KEGG	sgo:SGO_0660.
PATRIC	19659283. VBIStrGor124371_0649.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000029214.
HOGENOM	HBG540956.
OMA	FETDINT.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	SGOR29390:SGO_0660-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_STRGC

Accession

Primary (citable) accession number: A8AW03

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	October 23, 2007
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program