Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene

metE

Organism
Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.UniRule annotation

Catalytic activityi

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from L-homocysteine (MetE route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from L-homocysteine (MetE route), the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi636ZincUniRule annotation1
Metal bindingi638ZincUniRule annotation1
Metal bindingi721ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciSGOR467705:G1G95-311-MONOMER
UniPathwayiUPA00051; UER00082

Names & Taxonomyi

Protein namesi
Recommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotation (EC:2.1.1.14UniRule annotation)
Alternative name(s):
Cobalamin-independent methionine synthaseUniRule annotation
Methionine synthase, vitamin-B12 independent isozymeUniRule annotation
Gene namesi
Name:metEUniRule annotation
Ordered Locus Names:SGO_0310
OrganismiStreptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
Taxonomic identifieri467705 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001131 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000771211 – 7505-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseAdd BLAST750

Proteomic databases

PRIDEiA8AV19

Interactioni

Protein-protein interaction databases

STRINGi467705.SGO_0310

Structurei

3D structure databases

ProteinModelPortaliA8AV19
SMRiA8AV19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vitamin-B12 independent methionine synthase family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4107QYE Bacteria
COG0620 LUCA
HOGENOMiHOG000246221
KOiK00549
OMAiGRNIWKN
OrthoDBiPOG091H0282

Family and domain databases

Gene3Di3.20.20.210, 4 hits
HAMAPiMF_00172 Meth_synth, 1 hit
InterProiView protein in InterPro
IPR013215 Cbl-indep_Met_Synth_N
IPR006276 Cobalamin-indep_Met_synthase
IPR002629 Met_Synth_C/arc
IPR038071 UROD/MetE-like_sf
PfamiView protein in Pfam
PF08267 Meth_synt_1, 1 hit
PF01717 Meth_synt_2, 1 hit
PIRSFiPIRSF000382 MeTrfase_B12_ind, 1 hit
SUPFAMiSSF51726 SSF51726, 2 hits
TIGRFAMsiTIGR01371 met_syn_B12ind, 1 hit

Sequencei

Sequence statusi: Complete.

A8AV19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTIIGFPR LGEFRELKFT TEKYFRKEIS ADELLAAAKE LRAKHWNIVK
60 70 80 90 100
EKGISEIPSN DFSHYDNVLD AAFLFNVVPS SVRGLELTDL ERYFALARGY
110 120 130 140 150
QGEKGDVRAL PMKKWFNTNY HYIVPKFEKE TQVKLAGHKI FEEFAEAKEL
160 170 180 190 200
GLVTRPVVVG PFTLLQVSDF EDGVAPADFV DALATAYQEV FAKLAELGAK
210 220 230 240 250
RIQLDEPSLV KDLSAEEKAL FLDLYKKLLA DKKGLEVLIQ TYFGDVRDIY
260 270 280 290 300
SDLVQLPVDA IGLDFVEGKK TLELVKGGFP ADKTLYAGIV NGKNIWRNNY
310 320 330 340 350
EKSLAVLEQI PAENIVLTSS CSLLHVPFTT ANEEFEPAIL NHFAFAVEKL
360 370 380 390 400
DEIRDLDAIR NGQGAEALAA NKELFATERV GENAELRARI AGLTDADYTR
410 420 430 440 450
LPAFAEREAI QEEAFKLPAL PTTTIGSFPQ TKEVRAKRLA FRKGELSAED
460 470 480 490 500
YDKFLAEQID EWIKWQEEVG FDVLVHGEFE RNDMVEYFGQ NLSGYLFSKN
510 520 530 540 550
GWVQSYGMRG VKPPIIWGDV TRLNPITVKW SSYAQSRTEK PVKGMLTGPV
560 570 580 590 600
TILNWSFPRE DISIKDSTLQ IALAIKDEVL DLEAAGVKII QIDEAALREK
610 620 630 640 650
LPLRRSDWYE DYLDWAIPAF RLVHSTVAPD TQIHTHMCYS EFTDIIPAID
660 670 680 690 700
NMDADVISFE ASRSNLEILD ELKAKNFQTE VGPGVYDIHS PRVPNEGEID
710 720 730 740 750
HTIEAILAKV PSKKVWINPD CGLKTRGIPE TKASLVRLVE AAKAARQHLK
Length:750
Mass (Da):84,460
Last modified:October 23, 2007 - v1
Checksum:iEB639A5777CCE8D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000725 Genomic DNA Translation: ABV10872.1
RefSeqiWP_011999838.1, NC_009785.1

Genome annotation databases

EnsemblBacteriaiABV10872; ABV10872; SGO_0310
GeneIDi25052495
KEGGisgo:SGO_0310

Entry informationi

Entry nameiMETE_STRGC
AccessioniPrimary (citable) accession number: A8AV19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health