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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei258ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSGOR467705:G1G95-174-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:SGO_0174
OrganismiStreptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
Taxonomic identifieri467705 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001131 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000743391 – 485Glutamate--tRNA ligaseAdd BLAST485

Proteomic databases

PRIDEiA8AUN5

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi467705.SGO_0174

Structurei

3D structure databases

ProteinModelPortaliA8AUN5
SMRiA8AUN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 21"HIGH" regionUniRule annotationAdd BLAST11
Motifi255 – 259"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK09698
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A8AUN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKAIRVRYA PSPTGLLHIG NARTALFNYL YARHHGGTFI IRIEDTDRKR
60 70 80 90 100
HVEDGERSQL ENLRWLGMDW DESPETHENY RQSERLELYQ KYIDQLLAEG
110 120 130 140 150
KAYKSYVTEE ELAAERERQE AAGETPRYIN EYLGMSEEEK AAYIAEREAA
160 170 180 190 200
GIIPTVRLSV NESGIYKWHD IVKGDIEFEG GNIGGDWVIQ KKDGYPTYNF
210 220 230 240 250
AVVIDDHDMQ ISHVIRGDDH IANTPKQLMV YEALGWEAPE FGHMTLIINS
260 270 280 290 300
ETGKKLSKRD TNTLQFIEDY RKKGYLPEAV FNFIALLGWN PGGEDEIFSR
310 320 330 340 350
EELIKLFDEN RLSKSPAAFD QKKLDWMSNE YIKNADFERI FALAKPYLEE
360 370 380 390 400
AGRLTDKAEK LVELYKPQMK SVDEIVPLTD LFFSDFPELT EAEREVMAGE
410 420 430 440 450
TVPVVLEAFK AKLEAMTDEE FVTENIFPQI KAVQKETGIK GKNLFMPIRI
460 470 480
AVSGEMHGPE LPDTIYLLGR EKSIQHIENM LNQIQ
Length:485
Mass (Da):55,790
Last modified:October 23, 2007 - v1
Checksum:i3023945430AEB20A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000725 Genomic DNA Translation: ABV10390.1
RefSeqiWP_011999715.1, NC_009785.1

Genome annotation databases

EnsemblBacteriaiABV10390; ABV10390; SGO_0174
GeneIDi25051969
KEGGisgo:SGO_0174

Similar proteinsi

Entry informationi

Entry nameiSYE_STRGC
AccessioniPrimary (citable) accession number: A8AUN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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