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Protein

2,3-diketo-L-gulonate reductase

Gene

dlgD

Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.UniRule annotation

Catalytic activityi

3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44Proton donorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi168 – 174NADUniRule annotation7
Nucleotide bindingi224 – 225NADUniRule annotation2
Nucleotide bindingi304 – 306NADUniRule annotation3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciCKOS290338:G1G9Z-4421-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-diketo-L-gulonate reductaseUniRule annotation (EC:1.1.1.130UniRule annotation)
Short name:
2,3-DKG reductaseUniRule annotation
Alternative name(s):
3-dehydro-L-gulonate 2-dehydrogenaseUniRule annotation
Gene namesi
Name:dlgDUniRule annotation
Ordered Locus Names:CKO_05033
OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Taxonomic identifieri290338 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCitrobacter
Proteomesi
  • UP000008148 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000624381 – 3322,3-diketo-L-gulonate reductaseAdd BLAST332

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi290338.CKO_05033

Structurei

3D structure databases

ProteinModelPortaliA8ARG3
SMRiA8ARG3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DG4 Bacteria
COG2055 LUCA
HOGENOMiHOG000249660
KOiK08092
OMAiDGHYVLG
OrthoDBiPOG091H0T0F

Family and domain databases

HAMAPiMF_00820 Diketo_gul_reduc, 1 hit
InterProiView protein in InterPro
IPR023689 Diketo_gul_Rdtase
IPR036111 Mal/L-sulfo/L-lacto_DH-like_sf
IPR003767 Malate/L-lactate_DH-like
PANTHERiPTHR11091 PTHR11091, 1 hit
PfamiView protein in Pfam
PF02615 Ldh_2, 1 hit
SUPFAMiSSF89733 SSF89733, 1 hit

Sequencei

Sequence statusi: Complete.

A8ARG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVTFEQLKE AFNRVLLARG VAAETADACA EMFARTTESG VYSHGVNRFP
60 70 80 90 100
RFIQQLDNGD IIPDARPQRI TSLGAIEQWD AQRAIGNLTA KKMMDRAIEL
110 120 130 140 150
ASDHGIGLVA LRNANHWMRG GSYGWQAAEK GYIGICWTNS IAVMPPWGSK
160 170 180 190 200
ECRIGTNPLI VAIPSSPITM IDMSMSMFSY GMLEVNRLAG RELPVDGGFD
210 220 230 240 250
DEGNLTKEPG VIEKNRRILP MGYWKGSGLS IVLDMIATLL SDGASVAEVT
260 270 280 290 300
QENSDEYGVS QIFIAIEVDK LIDGATRDAK LQRIMDFVTT AERADENVAI
310 320 330
RLPGHEFTRL RDENRRNGIT VDDSVWAKIQ AL
Length:332
Mass (Da):36,653
Last modified:October 23, 2007 - v1
Checksum:i8407DBFF25D15CF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA Translation: ABV16076.1
RefSeqiWP_012135714.1, NC_009792.1

Genome annotation databases

EnsemblBacteriaiABV16076; ABV16076; CKO_05033
KEGGicko:CKO_05033

Similar proteinsi

Entry informationi

Entry nameiDLGD_CITK8
AccessioniPrimary (citable) accession number: A8ARG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: March 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health