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Protein

HTH-type transcriptional regulator MalT

Gene

malT

Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box): 5'-GGA[TG]GA-3'.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi39 – 468ATPUniRule annotation
DNA bindingi853 – 87220H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Carbohydrate metabolism, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCKOS290338:GJ8L-4822-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator MalTUniRule annotation
Alternative name(s):
ATP-dependent transcriptional activator MalTUniRule annotation
Gene namesi
Name:malTUniRule annotation
Ordered Locus Names:CKO_04840
OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Taxonomic identifieri290338 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter
Proteomesi
  • UP000008148 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 901901HTH-type transcriptional regulator MalTPRO_1000085764Add
BLAST

Interactioni

Subunit structurei

Monomer in solution but oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.UniRule annotation

Protein-protein interaction databases

STRINGi290338.CKO_04840.

Structurei

3D structure databases

ProteinModelPortaliA8AQX2.
SMRiA8AQX2. Positions 438-803.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini829 – 89466HTH luxR-typeUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH luxR-type DNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG41061ZR. Bacteria.
COG2909. LUCA.
HOGENOMiHOG000218261.
KOiK03556.
OMAiSDWVSNA.
OrthoDBiEOG69GZGV.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
HAMAPiMF_01247. HTH_type_MalT.
InterProiIPR027417. P-loop_NTPase.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR011990. TPR-like_helical_dom.
IPR023768. Tscrpt_reg_HTH_MalT.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8AQX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIPSKLSRP VRLDHTVVRE RLLAKLSGAN NFRLALVTSP AGYGKTTLVS
60 70 80 90 100
QWAAGKNELG WFSLDEGDNQ QERFASYLIA ALQQATGGHC STSEVMVQKR
110 120 130 140 150
QYVSLTSLFA QLFIELAEWH RPLYLVIDDY HLITNPVIHD AMRFFLRHQP
160 170 180 190 200
ENLTLVVLSR NLPQLGIANL RVRDQLLEIG SQQLAFNHQE AKQFFDRRLS
210 220 230 240 250
SPIEAAESSR MCDDVAGWAT ALQLIALSAR QNNNSAHQSA RRLAGINASH
260 270 280 290 300
LSDYLVDEVL DNVDVSTRHF LLKSAILRSM NDALIVRVTG EENGQMRLEE
310 320 330 340 350
IERQGLFLQR MDDTGEWFSY HPLFGSFLRQ RCQWELATEL PDIHRAAAES
360 370 380 390 400
WMAQGFPSEA IHHALAAGDA HMLRDILLNH AWGLFNHSEL ALLEESLKAL
410 420 430 440 450
PWESLLENPR LVLLQAWLMQ SQHRYSEVNT LLARAEQEIQ GMMDGTLHAE
460 470 480 490 500
FNALRAQVAI NDGNPDEAER LAKLALDELP IAWFYSRIVA TSVHGEVLHC
510 520 530 540 550
KGDLSRSLSL MQQTEQMSRH HDVWHYALWS LLQQSEILFA QGFLQAAWET
560 570 580 590 600
QEKAFQLIKE QHLEQLPMHE FLMRIRAQLL WAWARLDEAE ASARSGIDVL
610 620 630 640 650
SAFQPQQQLQ CLALLVQCSL ARGDLDNART QLNRLENLLG NGQYHSDWIS
660 670 680 690 700
NADKVRVIYW QMTGDKKSAA NWLRHTPKPE FANNHFLQGQ WRNIARAQIL
710 720 730 740 750
LGEFESAEIV LEELNENARS LRLMSDLNRN LLLLNQLYWQ AGRKNDAQRV
760 770 780 790 800
LLDALQLANR TGFISHFVIE GEAMAQQLRQ LIQLNTLPEL EQHRAQRILR
810 820 830 840 850
EINQHHRHKF AHFDEGFVER LLNHPDVPEL IRTSPLTQRE WQVLGLIYSG
860 870 880 890 900
YSNEQIAGEL AVAATTIKTH IRNLYQKLGV AHRQDAVQHA QRLLKMMGYG

V
Length:901
Mass (Da):103,064
Last modified:October 23, 2007 - v1
Checksum:i9CE578BE1D835AC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV15885.1.
RefSeqiWP_012135526.1. NC_009792.1.

Genome annotation databases

EnsemblBacteriaiABV15885; ABV15885; CKO_04840.
KEGGicko:CKO_04840.
PATRICi20391789. VBICitKos71230_4042.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV15885.1.
RefSeqiWP_012135526.1. NC_009792.1.

3D structure databases

ProteinModelPortaliA8AQX2.
SMRiA8AQX2. Positions 438-803.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290338.CKO_04840.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV15885; ABV15885; CKO_04840.
KEGGicko:CKO_04840.
PATRICi20391789. VBICitKos71230_4042.

Phylogenomic databases

eggNOGiENOG41061ZR. Bacteria.
COG2909. LUCA.
HOGENOMiHOG000218261.
KOiK03556.
OMAiSDWVSNA.
OrthoDBiEOG69GZGV.

Enzyme and pathway databases

BioCyciCKOS290338:GJ8L-4822-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
HAMAPiMF_01247. HTH_type_MalT.
InterProiIPR027417. P-loop_NTPase.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR011990. TPR-like_helical_dom.
IPR023768. Tscrpt_reg_HTH_MalT.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-895 / CDC 4225-83 / SGSC4696.

Entry informationi

Entry nameiMALT_CITK8
AccessioniPrimary (citable) accession number: A8AQX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: December 9, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.