Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A8AQ58

- IF2_CITK8

UniProt

A8AQ58 - IF2_CITK8

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi402 – 4098GTPUniRule annotation
Nucleotide bindingi448 – 4525GTPUniRule annotation
Nucleotide bindingi502 – 5054GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCKOS290338:GJ8L-4554-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:CKO_04569
OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Taxonomic identifieri290338 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter
ProteomesiUP000008148: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 894894Translation initiation factor IF-2PRO_1000008227Add
BLAST

Proteomic databases

PRIDEiA8AQ58.

Interactioni

Protein-protein interaction databases

STRINGi290338.CKO_04569.

Structurei

3D structure databases

ProteinModelPortaliA8AQ58.
SMRiA8AQ58. Positions 2-50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini393 – 562170tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni402 – 4098G1By similarity
Regioni427 – 4315G2By similarity
Regioni448 – 4514G3By similarity
Regioni502 – 5054G4By similarity
Regioni538 – 5403G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076907.
KOiK02519.
OMAiDNRTGGY.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8AQ58-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDVTVKALA AEIQTSVDRL VQQFADAGIP KSADDSVSAQ EKQTLLAHLN
60 70 80 90 100
RENGSGPDKL TLQRKTRSTL NIPGTGGKSK SVQIEVRKKR TFVKRDPQET
110 120 130 140 150
ERLAAEEQAQ REAEEQARRE AEETAKREAQ QKADREAAEQ AKRDAAEKAK
160 170 180 190 200
REAAEKDKVS NQQTDDMTKT AQAEKARREN EAAELKRKAE EEARRKLEEE
210 220 230 240 250
ARRVAEEARR MAEENKWTDN AEPTEDTSDY HVTTSQHARQ AEDENDREVE
260 270 280 290 300
GGRGRSRNAK AARPAKKGNK HSESKADREE ARAAVRGGKG GKNRKGSALQ
310 320 330 340 350
QSFQKPVQAV NRDVVIGETI TVGELANKMA VKGSQVIKAM MKLGAMATIN
360 370 380 390 400
QVIDQETAQL VAEEMGHKVI LRRENELEEA VMSDRDTGAA AEPRAPVVTI
410 420 430 440 450
MGHVDHGKTS LLDYIRSTKV ASGEAGGITQ HIGAYHVETD NGMITFLDTP
460 470 480 490 500
GHAAFTSMRA RGAQATDIVV LVVAADDGVM PQTIEAIQHA KAAGVPVVVA
510 520 530 540 550
VNKIDKPEAD PDRVKNELSQ YGILPEEWGG ESQFVHVSAK AGTGIDELLD
560 570 580 590 600
AILLQAEVLE LKAVRKGMAS GAVIESFLDK GRGPVATVLV REGTLNKGDI
610 620 630 640 650
VLCGFEYGRV RAMRNELGQE VLEAGPSIPV EILGLSGVPA AGDEVTVVRD
660 670 680 690 700
EKKAREVALY RQGKFREVKL ARQQKSKLEN MFANMTEGEV HEVNIVLKAD
710 720 730 740 750
VQGSVEAISD SLLKLSTDEV KVKIIGSGVG GITETDATLA AASNAILVGF
760 770 780 790 800
NVRADASARK VIEAESLDLR YYSVIYNLID EVKAAMSGML SPELKQQIIG
810 820 830 840 850
LAEVRDVFKS PKFGAVAGCM VTEGTIKRHN PIRVLRDNVV IYEGELESLR
860 870 880 890
RFKDDVNEVR NGMECGIGVK NYNDVRVGDM IEVFEIIEIQ RTIA
Length:894
Mass (Da):97,560
Last modified:October 23, 2007 - v1
Checksum:i9AE09ED9309727E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV15622.1.
RefSeqiYP_001456057.1. NC_009792.1.

Genome annotation databases

EnsemblBacteriaiABV15622; ABV15622; CKO_04569.
GeneIDi5581273.
KEGGicko:CKO_04569.
PATRICi20391321. VBICitKos71230_3816.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV15622.1 .
RefSeqi YP_001456057.1. NC_009792.1.

3D structure databases

ProteinModelPortali A8AQ58.
SMRi A8AQ58. Positions 2-50.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290338.CKO_04569.

Proteomic databases

PRIDEi A8AQ58.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV15622 ; ABV15622 ; CKO_04569 .
GeneIDi 5581273.
KEGGi cko:CKO_04569.
PATRICi 20391321. VBICitKos71230_3816.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076907.
KOi K02519.
OMAi DNRTGGY.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci CKOS290338:GJ8L-4554-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-895 / CDC 4225-83 / SGSC4696.

Entry informationi

Entry nameiIF2_CITK8
AccessioniPrimary (citable) accession number: A8AQ58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: November 26, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3