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A8AQ58

- IF2_CITK8

UniProt

A8AQ58 - IF2_CITK8

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi402 – 4098GTPUniRule annotation
    Nucleotide bindingi448 – 4525GTPUniRule annotation
    Nucleotide bindingi502 – 5054GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCKOS290338:GJ8L-4554-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:CKO_04569
    OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
    Taxonomic identifieri290338 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter
    ProteomesiUP000008148: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 894894Translation initiation factor IF-2PRO_1000008227Add
    BLAST

    Proteomic databases

    PRIDEiA8AQ58.

    Interactioni

    Protein-protein interaction databases

    STRINGi290338.CKO_04569.

    Structurei

    3D structure databases

    ProteinModelPortaliA8AQ58.
    SMRiA8AQ58. Positions 2-50.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini393 – 562170tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni402 – 4098G1By similarity
    Regioni427 – 4315G2By similarity
    Regioni448 – 4514G3By similarity
    Regioni502 – 5054G4By similarity
    Regioni538 – 5403G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076907.
    KOiK02519.
    OMAiDNRTGGY.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR009061. DNA-bd_dom_put.
    IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF46955. SSF46955. 1 hit.
    SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8AQ58-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDVTVKALA AEIQTSVDRL VQQFADAGIP KSADDSVSAQ EKQTLLAHLN    50
    RENGSGPDKL TLQRKTRSTL NIPGTGGKSK SVQIEVRKKR TFVKRDPQET 100
    ERLAAEEQAQ REAEEQARRE AEETAKREAQ QKADREAAEQ AKRDAAEKAK 150
    REAAEKDKVS NQQTDDMTKT AQAEKARREN EAAELKRKAE EEARRKLEEE 200
    ARRVAEEARR MAEENKWTDN AEPTEDTSDY HVTTSQHARQ AEDENDREVE 250
    GGRGRSRNAK AARPAKKGNK HSESKADREE ARAAVRGGKG GKNRKGSALQ 300
    QSFQKPVQAV NRDVVIGETI TVGELANKMA VKGSQVIKAM MKLGAMATIN 350
    QVIDQETAQL VAEEMGHKVI LRRENELEEA VMSDRDTGAA AEPRAPVVTI 400
    MGHVDHGKTS LLDYIRSTKV ASGEAGGITQ HIGAYHVETD NGMITFLDTP 450
    GHAAFTSMRA RGAQATDIVV LVVAADDGVM PQTIEAIQHA KAAGVPVVVA 500
    VNKIDKPEAD PDRVKNELSQ YGILPEEWGG ESQFVHVSAK AGTGIDELLD 550
    AILLQAEVLE LKAVRKGMAS GAVIESFLDK GRGPVATVLV REGTLNKGDI 600
    VLCGFEYGRV RAMRNELGQE VLEAGPSIPV EILGLSGVPA AGDEVTVVRD 650
    EKKAREVALY RQGKFREVKL ARQQKSKLEN MFANMTEGEV HEVNIVLKAD 700
    VQGSVEAISD SLLKLSTDEV KVKIIGSGVG GITETDATLA AASNAILVGF 750
    NVRADASARK VIEAESLDLR YYSVIYNLID EVKAAMSGML SPELKQQIIG 800
    LAEVRDVFKS PKFGAVAGCM VTEGTIKRHN PIRVLRDNVV IYEGELESLR 850
    RFKDDVNEVR NGMECGIGVK NYNDVRVGDM IEVFEIIEIQ RTIA 894
    Length:894
    Mass (Da):97,560
    Last modified:October 23, 2007 - v1
    Checksum:i9AE09ED9309727E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000822 Genomic DNA. Translation: ABV15622.1.
    RefSeqiYP_001456057.1. NC_009792.1.

    Genome annotation databases

    EnsemblBacteriaiABV15622; ABV15622; CKO_04569.
    GeneIDi5581273.
    KEGGicko:CKO_04569.
    PATRICi20391321. VBICitKos71230_3816.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000822 Genomic DNA. Translation: ABV15622.1 .
    RefSeqi YP_001456057.1. NC_009792.1.

    3D structure databases

    ProteinModelPortali A8AQ58.
    SMRi A8AQ58. Positions 2-50.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290338.CKO_04569.

    Proteomic databases

    PRIDEi A8AQ58.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV15622 ; ABV15622 ; CKO_04569 .
    GeneIDi 5581273.
    KEGGi cko:CKO_04569.
    PATRICi 20391321. VBICitKos71230_3816.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076907.
    KOi K02519.
    OMAi DNRTGGY.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci CKOS290338:GJ8L-4554-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR009061. DNA-bd_dom_put.
    IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46955. SSF46955. 1 hit.
    SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-895 / CDC 4225-83 / SGSC4696.

    Entry informationi

    Entry nameiIF2_CITK8
    AccessioniPrimary (citable) accession number: A8AQ58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3