Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G/U mismatch-specific DNA glycosylase

Gene

mug

Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.UniRule annotation

Catalytic activityi

Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

DNA damage, DNA excision, DNA repair

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciCKOS290338:GJ8L-4453-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
G/U mismatch-specific DNA glycosylaseUniRule annotation (EC:3.2.2.28UniRule annotation)
Alternative name(s):
Double-strand-specific uracil glycosylaseUniRule annotation
Mismatch-specific uracil DNA-glycosylaseUniRule annotation
Short name:
MUGUniRule annotation
Gene namesi
Name:mugUniRule annotation
Ordered Locus Names:CKO_04467
OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Taxonomic identifieri290338 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter
Proteomesi
  • UP000008148 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168G/U mismatch-specific DNA glycosylasePRO_1000070786Add
BLAST

Interactioni

Subunit structurei

Binds DNA as a monomer.UniRule annotation

Protein-protein interaction databases

STRINGi290338.CKO_04467.

Structurei

3D structure databases

ProteinModelPortaliA8APW0.
SMRiA8APW0. Positions 1-165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TDG/mug DNA glycosylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108VCA. Bacteria.
COG3663. LUCA.
HOGENOMiHOG000264684.
KOiK03649.
OMAiEVWVLPN.
OrthoDBiEOG68H872.

Family and domain databases

Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_01956. MUG.
InterProiIPR015637. MUG/TDG.
IPR023502. MUG_bact.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR12159. PTHR12159. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.

Sequencei

Sequence statusi: Complete.

A8APW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKDILAREL RVVFCGINPG LSSAGTGFPF AHPANRFWKV IHLAGFTGRQ
60 70 80 90 100
LKPEEAQHLL DFRCGVTKFV DRPTVQANEV KLQEMRSGGH KLIEKIEHYQ
110 120 130 140 150
PAALAILGKQ AFEQGFSQRG AQWGKQTMTI GDTQIWVLPN PSGLNRIRTE
160
KLVEAYRELD ESLVVDGL
Length:168
Mass (Da):18,810
Last modified:October 23, 2007 - v1
Checksum:i8632EAD829C6ACC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV15523.1.
RefSeqiWP_012135205.1. NC_009792.1.

Genome annotation databases

EnsemblBacteriaiABV15523; ABV15523; CKO_04467.
KEGGicko:CKO_04467.
PATRICi20391159. VBICitKos71230_3736.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV15523.1.
RefSeqiWP_012135205.1. NC_009792.1.

3D structure databases

ProteinModelPortaliA8APW0.
SMRiA8APW0. Positions 1-165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290338.CKO_04467.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV15523; ABV15523; CKO_04467.
KEGGicko:CKO_04467.
PATRICi20391159. VBICitKos71230_3736.

Phylogenomic databases

eggNOGiENOG4108VCA. Bacteria.
COG3663. LUCA.
HOGENOMiHOG000264684.
KOiK03649.
OMAiEVWVLPN.
OrthoDBiEOG68H872.

Enzyme and pathway databases

BioCyciCKOS290338:GJ8L-4453-MONOMER.

Family and domain databases

Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_01956. MUG.
InterProiIPR015637. MUG/TDG.
IPR023502. MUG_bact.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR12159. PTHR12159. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-895 / CDC 4225-83 / SGSC4696.

Entry informationi

Entry nameiMUG_CITK8
AccessioniPrimary (citable) accession number: A8APW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: May 11, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.