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A8APU0 (UPPP_CITK8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:CKO_04447
OrganismCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) [Complete proteome] [HAMAP]
Taxonomic identifier290338 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000062794

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane152 – 17423Helical; Potential
Transmembrane189 – 20921Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane251 – 27121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A8APU0 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: F6C1C181B38F1076

FASTA27229,544
        10         20         30         40         50         60 
MSDIHSLLVA AILGVVEGLT EFLPVSSTGH MIIVGHLLGF EGDTAETFEV VIQLGSILAV 

        70         80         90        100        110        120 
VVMFWRRLFG LIGIHFGKQP HEGTGKGRLT LGHIVLGMIP AVVLGLVFHD TIKSLFNPVN 

       130        140        150        160        170        180 
VMYALVVGGL LLIAAECLKP KEPRAPGLDD MTYRQAFMIG CFQCLALWPG FSRSGATISG 

       190        200        210        220        230        240 
GMLMGVSRYA ASEFSFLLAV PMMMGATALD LYKSWSFLTV EDIPMFAVGF VTAFIVALIA 

       250        260        270 
IKTFLQLIKR ISFIPFAIYR FIVAAAVYVV FF 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000822 Genomic DNA. Translation: ABV15503.1.
RefSeqYP_001455939.1. NC_009792.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290338.CKO_04447.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV15503; ABV15503; CKO_04447.
GeneID5581434.
KEGGcko:CKO_04447.
PATRIC20391121. VBICitKos71230_3717.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAFMNMFEY.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycCKOS290338:GJ8L-4433-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_CITK8
AccessionPrimary (citable) accession number: A8APU0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families