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A8APU0

- UPPP_CITK8

UniProt

A8APU0 - UPPP_CITK8

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, CKO_04447
Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCKOS290338:GJ8L-4433-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:CKO_04447
OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Taxonomic identifieri290338 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter
ProteomesiUP000008148: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421Helical; Reviewed predictionAdd
BLAST
Transmembranei45 – 6521Helical; Reviewed predictionAdd
BLAST
Transmembranei89 – 10921Helical; Reviewed predictionAdd
BLAST
Transmembranei115 – 13521Helical; Reviewed predictionAdd
BLAST
Transmembranei152 – 17423Helical; Reviewed predictionAdd
BLAST
Transmembranei189 – 20921Helical; Reviewed predictionAdd
BLAST
Transmembranei225 – 24521Helical; Reviewed predictionAdd
BLAST
Transmembranei251 – 27121Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Undecaprenyl-diphosphataseUniRule annotationPRO_1000062794Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290338.CKO_04447.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiFMNMFEY.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

A8APU0-1 [UniParc]FASTAAdd to Basket

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MSDIHSLLVA AILGVVEGLT EFLPVSSTGH MIIVGHLLGF EGDTAETFEV    50
VIQLGSILAV VVMFWRRLFG LIGIHFGKQP HEGTGKGRLT LGHIVLGMIP 100
AVVLGLVFHD TIKSLFNPVN VMYALVVGGL LLIAAECLKP KEPRAPGLDD 150
MTYRQAFMIG CFQCLALWPG FSRSGATISG GMLMGVSRYA ASEFSFLLAV 200
PMMMGATALD LYKSWSFLTV EDIPMFAVGF VTAFIVALIA IKTFLQLIKR 250
ISFIPFAIYR FIVAAAVYVV FF 272
Length:272
Mass (Da):29,544
Last modified:October 23, 2007 - v1
Checksum:iF6C1C181B38F1076
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000822 Genomic DNA. Translation: ABV15503.1.
RefSeqiWP_012135186.1. NC_009792.1.
YP_001455939.1. NC_009792.1.

Genome annotation databases

EnsemblBacteriaiABV15503; ABV15503; CKO_04447.
GeneIDi5581434.
KEGGicko:CKO_04447.
PATRICi20391121. VBICitKos71230_3717.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000822 Genomic DNA. Translation: ABV15503.1 .
RefSeqi WP_012135186.1. NC_009792.1.
YP_001455939.1. NC_009792.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290338.CKO_04447.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV15503 ; ABV15503 ; CKO_04447 .
GeneIDi 5581434.
KEGGi cko:CKO_04447.
PATRICi 20391121. VBICitKos71230_3717.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi FMNMFEY.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci CKOS290338:GJ8L-4433-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-895 / CDC 4225-83 / SGSC4696.

Entry informationi

Entry nameiUPPP_CITK8
AccessioniPrimary (citable) accession number: A8APU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi