A8APB4 (GCST_CITK8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	CKO_04269

Organism

Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) [Complete proteome] [HAMAP]

Taxonomic identifier

290338 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Citrobacter

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Aminomethyltransferase HAMAP MF_00259		PRO_1000047656

Sequences

	Sequence		Length	Mass (Da)
	A8APB4 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 201764107978387A	FASTA	364	40,089
	10 20 30 40 50 60 MAQQTPLYEQ HTLCGARMVD FHGWMMPLHY GSQLDEHHAV RTDAGMFDVS HMTIVDLRGS 70 80 90 100 110 120 RTREFLRYLL ANDVAKLTKT GKALYSGMLN ASGGVIDDLI VYYFTEDFFR LVVNSATREK 130 140 150 160 170 180 DLSWITQHAE PYAIDITVRD DLSLIAVQGP NAQAKAATLF TEEQRKAVEG MKPFFGVQAG 190 200 210 220 230 240 DLFIATTGYT GEAGYEIAMP NEKAADFWRA LVESGVKPCG LGARDTLRLE AGMNLYGQEM 250 260 270 280 290 300 DEGVSPLAAN MGWTIAWEPA DRDFIGREAL EVQREKGTEQ LVGLVMTEKG VLRNELPVRF 310 320 330 340 350 360 TDAQGNQLEG VITSGTFSPT LGYSIALARV PAGIGETAIV QIRNREMPVK VTKPVFVRNG KAVA

References

[1]

The Citrobacter koseri Genome Sequencing Project McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R. Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-895 / CDC 4225-83 / SGSC4696.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000822 Genomic DNA. Translation: ABV15327.1.
RefSeq	YP_001455763.1. NC_009792.1.
3D structure databases
ProteinModelPortal	A8APB4.
SMR	A8APB4. Positions 4-364.
ModBase	Search...
Protein-protein interaction databases
STRING	A8APB4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5584765.
GenomeReviews	Gene locus CKO_04269 in contig CP000822_GR.
KEGG	cko:CKO_04269.
PATRIC	20390813. VBICitKos71230_3564.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	NOG138489.
HOGENOM	HBG299834.
OMA	KALYGGM.
ProtClustDB	PRK00389.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_CITK8

Accession

Primary (citable) accession number: A8APB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 23, 2007
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program