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A8APB1 (GCSP_CITK8) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:CKO_04266
OrganismCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) [Complete proteome] [HAMAP]
Taxonomic identifier290338 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter

Protein attributes

Sequence length957 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 957957Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045579

Amino acid modifications

Modified residue7081N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A8APB1 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 6D2C8AD1F21CCE14

FASTA957104,552
        10         20         30         40         50         60 
MTQTLSQLEN SGAFIERHIG PDAAQQQEML NTVGAESLNA LIGQIVPKDI QLATPPQVGE 

        70         80         90        100        110        120 
AATEYAALAE LKAIAGRNKR FTSYIGMGYT AVQLPPVILR NMLENPGWYT AYTPYQPEVS 

       130        140        150        160        170        180 
QGRLEALLNF QQVTLDLTGL DMASASLLDE ATAAAEAMAM AKRISKLKNA NRFFVASDVH 

       190        200        210        220        230        240 
PQTLDVVRTR AETFGFDVIV DDAEKVLDHQ DVFGVLLQQV GTTGEVHDYS ALISELKSRK 

       250        260        270        280        290        300 
VIVSVAADFM ALVLLTAPGK QGADIVFGSA QRFGVPMGYG GPHAAFFAAK DEFKRSMPGR 

       310        320        330        340        350        360 
IIGVSKDAAG NTALRMAMQT REQHIRREKA NSNICTSQVL LANIASLYAV YHGPVGLKRI 

       370        380        390        400        410        420 
ANRIHRLTDI LAAGLQQKGL KLRHAHYFDT LCVEVADKAA VLARAEVAEI NLRSDIHNAV 

       430        440        450        460        470        480 
GITLDETTTR ENVLQLFSVL LGDDHGLNID TLDKDVAHDS RSIQESMLRD DAILTHPVFN 

       490        500        510        520        530        540 
RYHSETEMMR YMHSLERKDL ALNQAMIPLG SCTMKLNAAA EMIPITWPEF AELHPFCPAE 

       550        560        570        580        590        600 
QAEGYHQMIN QLSDWLVKLT GYDAVCMQPN SGAQGEYAGL LAIRHYHESR NDGHRDICLI 

       610        620        630        640        650        660 
PASAHGTNPA SAQMAGMQVV VVACDKNGNI DLADLRAKAE QAGDNLSCIM VTYPSTHGVY 

       670        680        690        700        710        720 
EETIREVCEI VHQFGGQVYL DGANMNAQVG ITSPGFIGAD VSHLNLHKTF CIPHGGGGPG 

       730        740        750        760        770        780 
MGPIGVKSHL APFVPGHSVV QIEGMLTRQG AVSAAPFGSA SILPISWMYI RMMGAEGLKQ 

       790        800        810        820        830        840 
ASQVAILNAN YIASRLKDAY PVLYTGRDGR VAHECILDIR PLKEETGISE LDIAKRLIDY 

       850        860        870        880        890        900 
GFHAPTMSFP VAGTLMVEPT ESESKMELDR FINAMLAIRA EIDRVKAGEW PLEDNPLVNA 

       910        920        930        940        950 
PHTQNELVAE WNHGYSREVA VFPAGVANKY WPTVKRLDDV YGDRNLFCSC VPMSEYQ 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000822 Genomic DNA. Translation: ABV15324.1.
RefSeqYP_001455760.1. NC_009792.1.

3D structure databases

ProteinModelPortalA8APB1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290338.CKO_04266.

Proteomic databases

PRIDEA8APB1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV15324; ABV15324; CKO_04266.
GeneID5580741.
KEGGcko:CKO_04266.
PATRIC20390809. VBICitKos71230_3562.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycCKOS290338:GJ8L-4252-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_CITK8
AccessionPrimary (citable) accession number: A8APB1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families