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A8AP13

- FUCI_CITK8

UniProt

A8AP13 - FUCI_CITK8

Protein

L-fucose isomerase

Gene

fucI

Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

    Catalytic activityi

    L-fucopyranose = L-fuculose.UniRule annotation

    Cofactori

    Manganese.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei337 – 3371Proton acceptorUniRule annotation
    Metal bindingi337 – 3371ManganeseUniRule annotation
    Active sitei361 – 3611Proton acceptorUniRule annotation
    Metal bindingi361 – 3611ManganeseUniRule annotation
    Metal bindingi528 – 5281ManganeseUniRule annotation

    GO - Molecular functioni

    1. L-fucose isomerase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-fucose catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism, Fucose metabolism

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciCKOS290338:GJ8L-4151-MONOMER.
    UniPathwayiUPA00563; UER00624.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
    Alternative name(s):
    6-deoxy-L-galactose isomeraseUniRule annotation
    FucIase
    Gene namesi
    Name:fucIUniRule annotation
    Ordered Locus Names:CKO_04161
    OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
    Taxonomic identifieri290338 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter
    ProteomesiUP000008148: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 591591L-fucose isomerasePRO_1000067215Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer.UniRule annotation

    Protein-protein interaction databases

    STRINGi290338.CKO_04161.

    Structurei

    3D structure databases

    ProteinModelPortaliA8AP13.
    SMRiA8AP13. Positions 1-591.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L-fucose isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2407.
    HOGENOMiHOG000249674.
    KOiK01818.
    OMAiKEGQDYR.
    OrthoDBiEOG6FJNCF.

    Family and domain databases

    Gene3Di3.20.14.10. 1 hit.
    3.40.275.10. 1 hit.
    3.40.50.1070. 1 hit.
    HAMAPiMF_01254. Fucose_iso.
    InterProiIPR004216. Fuc/Ara_isomerase_C.
    IPR015888. Fuc_isomerase_C.
    IPR012888. Fucose_iso_N1.
    IPR005763. Fucose_isomerase.
    IPR009015. Fucose_isomerase_N/cen.
    IPR012889. Fucose_isomerase_N2.
    [Graphical view]
    PfamiPF02952. Fucose_iso_C. 1 hit.
    PF07881. Fucose_iso_N1. 1 hit.
    PF07882. Fucose_iso_N2. 1 hit.
    [Graphical view]
    SUPFAMiSSF50443. SSF50443. 1 hit.
    SSF53743. SSF53743. 1 hit.
    TIGRFAMsiTIGR01089. fucI. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8AP13-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKISLPKIG IRPVIDGRRM GVRESLEEQT MNMAKATAAL ITEKLRHACG    50
    AQIECVIADT CIAGMAESAA CEEKFSSQNV GVTITVTPCW CYGSETIDMD 100
    PMRPKAIWGF NGTERPGAVY LAAALAAHSQ KGIPAFSIYG HDVQDADDTS 150
    IPADVEEKLL RFARAGLAVA SMKGKSYLSV GGVSMGIAGS IVDHNFFESW 200
    LGMKVQAVDM TELRRRIDQK IYDEAELEMA LAWADKNFRY GEDQNAQQYK 250
    RNEEQSRAVL KESLLMAMCI RDMMQGNNKL AEKGLVEESL GYNAIAAGFQ 300
    GQRHWTDQYP NGDTAEALLN SSFDWNGVRE PFVVATENDS LNGVAMLLGH 350
    QLTGTAQVFA DVRTYWSPEA VERVTGQPLT GLAEHGIIHL INSGSAALDG 400
    SCKQRDSEGK PTMKPHWEIS QQEADACLAA TEWCPAIHEY FRGGGYSSRF 450
    LTEGGVPFTM TRVNIIKGLG PVLQIAEGWS VELPKEMHDQ LDARTNSTWP 500
    TTWFAPRLTG KGPFTDVYSV MANWGANHGV LTIGHVGADF ITLAAMLRIP 550
    VCMHNVDDAK IYRPSAWAAH GMDIEGQDYR ACQNYGPLYK R 591
    Length:591
    Mass (Da):64,922
    Last modified:October 23, 2007 - v1
    Checksum:iABC2620C353C5907
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000822 Genomic DNA. Translation: ABV15226.1.
    RefSeqiWP_012134915.1. NC_009792.1.
    YP_001455662.1. NC_009792.1.

    Genome annotation databases

    EnsemblBacteriaiABV15226; ABV15226; CKO_04161.
    GeneIDi5584174.
    KEGGicko:CKO_04161.
    PATRICi20390647. VBICitKos71230_3485.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000822 Genomic DNA. Translation: ABV15226.1 .
    RefSeqi WP_012134915.1. NC_009792.1.
    YP_001455662.1. NC_009792.1.

    3D structure databases

    ProteinModelPortali A8AP13.
    SMRi A8AP13. Positions 1-591.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290338.CKO_04161.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV15226 ; ABV15226 ; CKO_04161 .
    GeneIDi 5584174.
    KEGGi cko:CKO_04161.
    PATRICi 20390647. VBICitKos71230_3485.

    Phylogenomic databases

    eggNOGi COG2407.
    HOGENOMi HOG000249674.
    KOi K01818.
    OMAi KEGQDYR.
    OrthoDBi EOG6FJNCF.

    Enzyme and pathway databases

    UniPathwayi UPA00563 ; UER00624 .
    BioCyci CKOS290338:GJ8L-4151-MONOMER.

    Family and domain databases

    Gene3Di 3.20.14.10. 1 hit.
    3.40.275.10. 1 hit.
    3.40.50.1070. 1 hit.
    HAMAPi MF_01254. Fucose_iso.
    InterProi IPR004216. Fuc/Ara_isomerase_C.
    IPR015888. Fuc_isomerase_C.
    IPR012888. Fucose_iso_N1.
    IPR005763. Fucose_isomerase.
    IPR009015. Fucose_isomerase_N/cen.
    IPR012889. Fucose_isomerase_N2.
    [Graphical view ]
    Pfami PF02952. Fucose_iso_C. 1 hit.
    PF07881. Fucose_iso_N1. 1 hit.
    PF07882. Fucose_iso_N2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50443. SSF50443. 1 hit.
    SSF53743. SSF53743. 1 hit.
    TIGRFAMsi TIGR01089. fucI. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-895 / CDC 4225-83 / SGSC4696.

    Entry informationi

    Entry nameiFUCI_CITK8
    AccessioniPrimary (citable) accession number: A8AP13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3