Reviewed, UniProtKB/Swiss-Prot A8AL09 (CDH_CITK8)

Names and origin

Protein names

Recommended name:
    CDP-diacylglycerol pyrophosphatase
    EC=3.6.1.26
Alternative name(s):
    CDP-diacylglycerol phosphatidylhydrolase
    CDP-diglyceride hydrolase

Gene names

Name:	cdh
Ordered Locus Names:	CKO_03081

Organism

Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) [Complete proteome] [HAMAP]

Taxonomic identifier

290338 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Citrobacter

Protein attributes

Sequence length	249 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CDP-diacylglycerol + H2O = CMP + phosphatidate. HAMAP MF_00319
Pathway	Phospholipid metabolism; CDP-diacylglycerol degradation; phosphatidate from CDP-diacylglycerol: step 1/1. HAMAP MF_00319
Subcellular location	Cell inner membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the cdh family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	CDP-diacylglycerol diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 249	249	CDP-diacylglycerol pyrophosphatase HAMAP MF_00319		PRO_1000019262
Regions
	Transmembrane	7 – 27	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	A8AL09-1 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 114B0CAB4D897F5E	FASTA	249	27,971
	10 20 30 40 50 60 MKKTGYFLLA VVIVAAVAGI GYWKLAANPN ALRDIVLQQC VPNQLQQQNP APCAEVKPDA 70 80 90 100 110 120 GYVVFKDRNG PLQYLLMPTY RINGTESPLL VEPYTPNFFW LAWQARSFMS QKYGKDIPDS 130 140 150 160 170 180 AISLAINSRS GRTQNHFHIH ISCLRPDVRA QLDDNLAKVS TRWLPLPGGL RGNEYLARRV 190 200 210 220 230 240 TESELAQRSP FMMLAEEVPD AREHMGSYAL AVVRQSDDSF VLLATQRNLL AFNLASAEEI QDHQCEILQ

References

[1]	McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R. Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000822 Genomic DNA. Translation: ABV14172.1.
RefSeq	YP_001454608.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5584876.
GenomeReviews	Gene locus CKO_03081 in contig CP000822_GR.
KEGG	cko:CKO_03081.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A8AL09. EIQDHEC.
Family and domain databases
HAMAP	MF_00319. [Tree]
InterPro	IPR003763. CDP-diacylglyc_Pase_bac. IPR015993. CDP-diacylglyc_Pase_proteobac. [Graphical view]
Pfam	PF02611. CDH. 1 hit. [Graphical view]
PIRSF	PIRSF001273. CDH. 1 hit.
TIGRFAMs	TIGR00672. cdh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CDH_CITK8

Accession

Primary (citable) accession number: A8AL09

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 23, 2007
Last modified:	June 16, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)