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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.UniRule annotation

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (CKO_00756)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

BioCyciCKOS290338:G1G9Z-2071-MONOMER
UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonaseUniRule annotation (EC:3.1.1.31UniRule annotation)
Short name:
6-P-gluconolactonaseUniRule annotation
Gene namesi
Name:pglUniRule annotation
Ordered Locus Names:CKO_02368
OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Taxonomic identifieri290338 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCitrobacter
Proteomesi
  • UP000008148 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003234981 – 3316-phosphogluconolactonaseAdd BLAST331

Proteomic databases

PRIDEiA8AJ27

Interactioni

Protein-protein interaction databases

STRINGi290338.CKO_02368

Structurei

3D structure databases

ProteinModelPortaliA8AJ27
SMRiA8AJ27
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105HHQ Bacteria
COG2706 LUCA
HOGENOMiHOG000257418
KOiK07404
OrthoDBiPOG091H07R3

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_01605 6P_gluconolactonase, 1 hit
InterProiView protein in InterPro
IPR022528 6-phosphogluconolactonase_YbhE
IPR019405 Lactonase_7-beta_prop
IPR011045 N2O_reductase_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF10282 Lactonase, 1 hit
SUPFAMiSSF50974 SSF50974, 1 hit

Sequencei

Sequence statusi: Complete.

A8AJ27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQTVYTASP ESQQIHVWSL NHDGSLKLVQ VVDVPGQVQP MVVSPDKRYL
60 70 80 90 100
YVGVRPEFRV LAYRIAPDDG ALTFAAESAL PGSPTHISTD HQGRFVFVGS
110 120 130 140 150
YNAGNVSVTR LDDGLPAGVV DVVEGLEGCH SANISPDNRT LWVPALKQDR
160 170 180 190 200
ICLFTLSDDG KLVAQEPAEV TTVEGAGPRH MAFHPNQQYA YCVNELNSSV
210 220 230 240 250
DVWELKDPHG NIECVQTLDM MPADFSDTRW AADIHITPDG RHLYACDRTA
260 270 280 290 300
SLITVFSVSE DGSVLTKEGF QPTETQPRGF NVDHSGKYLI AAGQKSHHIA
310 320 330
VYAIAGEQGL LTEKGRYAVG QGPMWVVVNA Y
Length:331
Mass (Da):36,131
Last modified:March 18, 2008 - v2
Checksum:iB0A0AB797CE63183
GO

Sequence cautioni

The sequence ABV13490 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA Translation: ABV13490.1 Different initiation.
RefSeqiWP_024130516.1, NC_009792.1

Genome annotation databases

EnsemblBacteriaiABV13490; ABV13490; CKO_02368
KEGGicko:CKO_02368

Similar proteinsi

Entry informationi

Entry namei6PGL_CITK8
AccessioniPrimary (citable) accession number: A8AJ27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: May 23, 2018
This is version 62 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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