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Protein

NAD(P)H dehydrogenase (quinone)

Gene

CKO_02047

Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.UniRule annotation

Cofactori

FMNUniRule annotationNote: Binds 1 FMN per monomer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei12 – 121NAD(P)UniRule annotation
Binding sitei51 – 511NAD(P); via carbonyl oxygenUniRule annotation
Binding sitei98 – 981SubstrateUniRule annotation
Binding sitei133 – 1331FMNUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 145FMNUniRule annotation
Nucleotide bindingi110 – 16152FMNUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciCKOS290338:GJ8L-2044-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H dehydrogenase (quinone)UniRule annotation (EC:1.6.5.2UniRule annotation)
Alternative name(s):
Flavoprotein WrbA
NAD(P)H:quinone oxidoreductaseUniRule annotation
Short name:
NQOUniRule annotation
Gene namesi
Ordered Locus Names:CKO_02047
OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Taxonomic identifieri290338 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter
Proteomesi
  • UP000008148 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198NAD(P)H dehydrogenase (quinone)PRO_1000084135Add
BLAST

Proteomic databases

PRIDEiA8AI59.

Interactioni

Protein-protein interaction databases

STRINGi290338.CKO_02047.

Structurei

3D structure databases

ProteinModelPortaliA8AI59.
SMRiA8AI59. Positions 2-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 189186Flavodoxin-likeUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the WrbA family.UniRule annotation
Contains 1 flavodoxin-like domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CS1. Bacteria.
COG0655. LUCA.
HOGENOMiHOG000030539.
KOiK03809.
OMAiWMKGALV.
OrthoDBiEOG6384K0.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01017. NQOR.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like_dom.
IPR010089. Flavoprotein_WrbA.
IPR005025. FMN_Rdtase-like.
[Graphical view]
PfamiPF03358. FMN_red. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR01755. flav_wrbA. 1 hit.
PROSITEiPS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8AI59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKILVLYYS MYGHIETMAH AVAEGANKVD GAEVVIKRVP ETMQPEIFAK
60 70 80 90 100
AGGKTQNAPV ATPQELPDYD AIIFGTPTRF GNMSGQMRTF LDQTGGLWAS
110 120 130 140 150
GALYGKLASV FSSTGTGGGQ EQTITSTWTT LAHHGMVIVP IGYAAQELFD
160 170 180 190
VSQVRGGTPY GATTIAGGDG SRQPSQEELS IARYQGEYVA GLAVKLNG
Length:198
Mass (Da):20,895
Last modified:October 23, 2007 - v1
Checksum:iEAC0032149DB20B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV13172.1.
RefSeqiWP_012132908.1. NC_009792.1.

Genome annotation databases

EnsemblBacteriaiABV13172; ABV13172; CKO_02047.
KEGGicko:CKO_02047.
PATRICi20386987. VBICitKos71230_1708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV13172.1.
RefSeqiWP_012132908.1. NC_009792.1.

3D structure databases

ProteinModelPortaliA8AI59.
SMRiA8AI59. Positions 2-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290338.CKO_02047.

Proteomic databases

PRIDEiA8AI59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV13172; ABV13172; CKO_02047.
KEGGicko:CKO_02047.
PATRICi20386987. VBICitKos71230_1708.

Phylogenomic databases

eggNOGiENOG4105CS1. Bacteria.
COG0655. LUCA.
HOGENOMiHOG000030539.
KOiK03809.
OMAiWMKGALV.
OrthoDBiEOG6384K0.

Enzyme and pathway databases

BioCyciCKOS290338:GJ8L-2044-MONOMER.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01017. NQOR.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like_dom.
IPR010089. Flavoprotein_WrbA.
IPR005025. FMN_Rdtase-like.
[Graphical view]
PfamiPF03358. FMN_red. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR01755. flav_wrbA. 1 hit.
PROSITEiPS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-895 / CDC 4225-83 / SGSC4696.

Entry informationi

Entry nameiNQOR_CITK8
AccessioniPrimary (citable) accession number: A8AI59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: January 20, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.