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Protein

Multidrug resistance protein MdtG

Gene

mdtG

Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtGUniRule annotation
Gene namesi
Name:mdtGUniRule annotation
Ordered Locus Names:CKO_02014
OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Taxonomic identifieri290338 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCitrobacter
Proteomesi
  • UP000008148 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalUniRule annotationAdd BLAST21
Transmembranei56 – 76HelicalUniRule annotationAdd BLAST21
Transmembranei90 – 110HelicalUniRule annotationAdd BLAST21
Transmembranei113 – 133HelicalUniRule annotationAdd BLAST21
Transmembranei144 – 164HelicalUniRule annotationAdd BLAST21
Transmembranei171 – 191HelicalUniRule annotationAdd BLAST21
Transmembranei222 – 242HelicalUniRule annotationAdd BLAST21
Transmembranei254 – 274HelicalUniRule annotationAdd BLAST21
Transmembranei288 – 308HelicalUniRule annotationAdd BLAST21
Transmembranei317 – 337HelicalUniRule annotationAdd BLAST21
Transmembranei376 – 396HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000686731 – 406Multidrug resistance protein MdtGAdd BLAST406

Interactioni

Protein-protein interaction databases

STRINGi290338.CKO_02014.

Structurei

3D structure databases

ProteinModelPortaliA8AI28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C6X. Bacteria.
ENOG410ZVCH. LUCA.
HOGENOMiHOG000066093.
KOiK08161.
OMAiFTQSNAD.
OrthoDBiPOG091H029Y.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01528. MFS_MdtG. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023692. Mutidrug-R_MdtG.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8AI28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPSDVPINW KRNLTVAWLG CFLTGAAFSL VMPFLPLYVE QLGVTGHSAL
60 70 80 90 100
NMWSGLVFSI TFLFSAIASP FWGGLADRKG RKIMLLRSAL GMAIVMLLMG
110 120 130 140 150
LAQNIWQFLL LRALLGLLGG FVPNANALIA TQVPRNKSGW ALGTLSTGGV
160 170 180 190 200
SGALLGPLAG GLLADQYGLR PVFFITASVL LVCFLLTLFF TRERFQPVSK
210 220 230 240 250
KEMLHVREVV GSLKNPKLVL SLFVTTLIIQ VATGSIAPIL TLYVRELAGN
260 270 280 290 300
VSNIAFISGM IASVPGVAAL LSAPRLGKLG DRIGPEKILI TALIISVLLL
310 320 330 340 350
IPMSFVQTPW QLGVLRFLLG AADGALLPAV QTLLVYNASN QIAGRIFSYN
360 370 380 390 400
QSFRDIGNVT GPLMGAAISA SYGFRAVFCV TAGVVLFNAI YSWNSLRRRR

ETLAAK
Length:406
Mass (Da):43,554
Last modified:October 23, 2007 - v1
Checksum:i43EFF50557E032D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV13140.1.
RefSeqiWP_012132877.1. NC_009792.1.

Genome annotation databases

EnsemblBacteriaiABV13140; ABV13140; CKO_02014.
KEGGicko:CKO_02014.
PATRICi20386933. VBICitKos71230_1682.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV13140.1.
RefSeqiWP_012132877.1. NC_009792.1.

3D structure databases

ProteinModelPortaliA8AI28.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290338.CKO_02014.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV13140; ABV13140; CKO_02014.
KEGGicko:CKO_02014.
PATRICi20386933. VBICitKos71230_1682.

Phylogenomic databases

eggNOGiENOG4105C6X. Bacteria.
ENOG410ZVCH. LUCA.
HOGENOMiHOG000066093.
KOiK08161.
OMAiFTQSNAD.
OrthoDBiPOG091H029Y.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01528. MFS_MdtG. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023692. Mutidrug-R_MdtG.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDTG_CITK8
AccessioniPrimary (citable) accession number: A8AI28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: November 2, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.