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Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571ZincUniRule annotation
Metal bindingi177 – 1771ZincUniRule annotation
Metal bindingi179 – 1791ZincUniRule annotation
Metal bindingi184 – 1841ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 118ATPUniRule annotation
Nucleotide bindingi133 – 1408ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciCKOS290338:GJ8L-1929-MONOMER.
UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
Alternative name(s):
GlcNAc kinaseUniRule annotation
Gene namesi
Name:nagKUniRule annotation
Ordered Locus Names:CKO_01932
OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Taxonomic identifieri290338 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter
ProteomesiUP000008148 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303N-acetyl-D-glucosamine kinasePRO_1000067378Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290338.CKO_01932.

Structurei

3D structure databases

ProteinModelPortaliA8AHU6.
SMRiA8AHU6. Positions 1-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
KOiK00884.
OMAiWIGNDAD.
OrthoDBiEOG61P6P0.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8AHU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYYGFDIGGT KIALGVFDNE RRLRWEKRVP TPREGYEAFL TAVCDLVAEA
60 70 80 90 100
DQRFDVKGSV GIGIPGMPET EDGTLYAANV PAASGKPLRA DLSARLDRDV
110 120 130 140 150
RLDNDANCFA LSEAWDDEFT QYPLVMGLIL GTGVGGGLVL NGKPITGCSY
160 170 180 190 200
ITGEFGHMRL PVDALTLMGF DFPLRRCGCG QLGCIENYLS GRGFAWLYQH
210 220 230 240 250
YYHQPLQAPE IIALWEQGDE RARAHVERYL DLLAVCLGNI LTIVDPDLVV
260 270 280 290 300
IGGGLSNFTA ITTQLADRLP RHLLPVARVP RIERARHGDA GGMRGAAFLH

LTD
Length:303
Mass (Da):33,210
Last modified:October 23, 2007 - v1
Checksum:i2AC1E4B7A766AEE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV13059.1.
RefSeqiWP_012132796.1. NC_009792.1.

Genome annotation databases

EnsemblBacteriaiABV13059; ABV13059; CKO_01932.
KEGGicko:CKO_01932.
PATRICi20386801. VBICitKos71230_1616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV13059.1.
RefSeqiWP_012132796.1. NC_009792.1.

3D structure databases

ProteinModelPortaliA8AHU6.
SMRiA8AHU6. Positions 1-303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290338.CKO_01932.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV13059; ABV13059; CKO_01932.
KEGGicko:CKO_01932.
PATRICi20386801. VBICitKos71230_1616.

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
KOiK00884.
OMAiWIGNDAD.
OrthoDBiEOG61P6P0.

Enzyme and pathway databases

UniPathwayiUPA00544.
BioCyciCKOS290338:GJ8L-1929-MONOMER.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-895 / CDC 4225-83 / SGSC4696.

Entry informationi

Entry nameiNAGK_CITK8
AccessioniPrimary (citable) accession number: A8AHU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: May 27, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.