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Protein

Multidrug resistance protein MdtK

Gene

mdtK

Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Multidrug efflux pump that functions probably as a Na+/drug antiporter.UniRule annotation

GO - Molecular functioni

  1. antiporter activity Source: UniProtKB-HAMAP
  2. drug transmembrane transporter activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. sodium ion transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciCKOS290338:GJ8L-1676-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtKUniRule annotation
Alternative name(s):
Multidrug-efflux transporterUniRule annotation
Gene namesi
Name:mdtKUniRule annotation
Ordered Locus Names:CKO_01679
OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Taxonomic identifieri290338 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter
ProteomesiUP000008148 Componenti: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalUniRule annotationAdd
BLAST
Transmembranei53 – 7321HelicalUniRule annotationAdd
BLAST
Transmembranei93 – 11321HelicalUniRule annotationAdd
BLAST
Transmembranei127 – 14721HelicalUniRule annotationAdd
BLAST
Transmembranei160 – 18021HelicalUniRule annotationAdd
BLAST
Transmembranei188 – 20821HelicalUniRule annotationAdd
BLAST
Transmembranei243 – 26321HelicalUniRule annotationAdd
BLAST
Transmembranei276 – 29621HelicalUniRule annotationAdd
BLAST
Transmembranei314 – 33421HelicalUniRule annotationAdd
BLAST
Transmembranei357 – 37721HelicalUniRule annotationAdd
BLAST
Transmembranei387 – 40721HelicalUniRule annotationAdd
BLAST
Transmembranei418 – 43821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Multidrug resistance protein MdtKPRO_1000049612Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290338.CKO_01679.

Family & Domainsi

Sequence similaritiesi

Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000038538.
KOiK03327.
OMAiSIVFMLP.
OrthoDBiEOG6423C5.

Family and domain databases

HAMAPiMF_00400. MdtK.
InterProiIPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
PIRSFiPIRSF006603. DinF. 1 hit.
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A8AH48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKYISEARQ LLALAIPVIL AQIAQTAMGF VDTVMAGGYS ATDMAAVAIG
60 70 80 90 100
TSIWLPAILF GHGLLLALTP VIAQLNGSGR RERIAHQVRQ GFWLAGCVSV
110 120 130 140 150
LIMFVLWNAG YIIRSMHNID PALADKAVGY LRALLWGAPG YLFFQVARNQ
160 170 180 190 200
CEGLAKTKPG MVIGFLGLLV NIPVNYIFIY GHFGMPELGG VGCGVATAAV
210 220 230 240 250
YWVMFIAMAS YVKRARSMRD IRNERGFSKP DTAVMKRLVQ LGLPIALALF
260 270 280 290 300
FEVTLFAVVA LLVSPLGIVD VAGHQIALNF SSLMFVLPMS LAAAVTIRVG
310 320 330 340 350
YRLGQGSTLD AQTAARTGLG VGVCMAVITA IFTVTLREPI ALLYNDNPEV
360 370 380 390 400
VTLAAQLMLL AAVYQISDSI QVIGSGILRG YKDTRSIFFI TFTAYWVLGL
410 420 430 440 450
PSGYILALTD LVVDRMGPAG FWMGFIIGLT SAAIMMMLRM RYLQRQSSAI

ILQRAAR
Length:457
Mass (Da):49,430
Last modified:October 22, 2007 - v1
Checksum:iF0856B62084A417F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV12811.1.
RefSeqiWP_012132551.1. NC_009792.1.
YP_001453247.1. NC_009792.1.

Genome annotation databases

EnsemblBacteriaiABV12811; ABV12811; CKO_01679.
GeneIDi5584585.
KEGGicko:CKO_01679.
PATRICi20386391. VBICitKos71230_1413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV12811.1.
RefSeqiWP_012132551.1. NC_009792.1.
YP_001453247.1. NC_009792.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290338.CKO_01679.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV12811; ABV12811; CKO_01679.
GeneIDi5584585.
KEGGicko:CKO_01679.
PATRICi20386391. VBICitKos71230_1413.

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000038538.
KOiK03327.
OMAiSIVFMLP.
OrthoDBiEOG6423C5.

Enzyme and pathway databases

BioCyciCKOS290338:GJ8L-1676-MONOMER.

Family and domain databases

HAMAPiMF_00400. MdtK.
InterProiIPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
PIRSFiPIRSF006603. DinF. 1 hit.
TIGRFAMsiTIGR00797. matE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-895 / CDC 4225-83 / SGSC4696.

Entry informationi

Entry nameiMDTK_CITK8
AccessioniPrimary (citable) accession number: A8AH48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 14, 2008
Last sequence update: October 22, 2007
Last modified: March 31, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.