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Protein

Pyridoxal kinase PdxY

Gene

pdxY

Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP.UniRule annotationSAAS annotation

Catalytic activityi

ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Pathwayi: pyridoxal 5'-phosphate salvage

This protein is involved in step 1 of the subpathway that synthesizes pyridoxal 5'-phosphate from pyridoxal.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pyridoxal kinase PdxY (pdxY), Pyridoxal kinase (CKO_00372)
This subpathway is part of the pathway pyridoxal 5'-phosphate salvage, which is itself part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxal 5'-phosphate from pyridoxal, the pathway pyridoxal 5'-phosphate salvage and in Cofactor metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei12 – 121SubstrateUniRule annotation
Binding sitei114 – 1141ATPUniRule annotation
Binding sitei146 – 1461ATP; via carbonyl oxygenUniRule annotation
Binding sitei151 – 1511ATPUniRule annotation
Binding sitei184 – 1841ATPUniRule annotation
Binding sitei226 – 2261SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi211 – 2144ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCKOS290338:GJ8L-1645-MONOMER.
UniPathwayiUPA01068; UER00298.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxal kinase PdxYUniRule annotationSAAS annotation (EC:2.7.1.35UniRule annotationSAAS annotation)
Short name:
PL kinaseUniRule annotation
Gene namesi
Name:pdxYUniRule annotation
Ordered Locus Names:CKO_01648Imported
OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)Imported
Taxonomic identifieri290338 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter
Proteomesi
  • UP000008148 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi290338.CKO_01648.

Structurei

3D structure databases

ProteinModelPortaliA8AH17.
SMRiA8AH17. Positions 4-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 263187Phos_pyr_kinInterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni47 – 482SubstrateUniRule annotation

Sequence similaritiesi

Belongs to the pyridoxine kinase family. PdxY subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107XGF. Bacteria.
COG2240. LUCA.
HOGENOMiHOG000258173.
KOiK00868.
OMAiCPNQLEL.
OrthoDBiEOG69PQ1X.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_01639. PdxY.
InterProiIPR013749. PM/HMP-P_kinase-1.
IPR004625. PyrdxlKinase.
IPR023685. Pyridoxal_kinase_PdxY.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR10534. PTHR10534. 1 hit.
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00687. pyridox_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

A8AH17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNMKNILAI QSHVVFGHAG NSAAEFPMRR LGANVWPLNT VQFSNHTQYG
60 70 80 90 100
KWTGCVMPPE HLTEIVQGIA DIDKLQTCDA VLSGYLGSAE QGEHILGIVR
110 120 130 140 150
KVKVANPQAK YFCDPVMGHP EKGCIVAPGV AEFHVRHALP ASDIIAPNLV
160 170 180 190 200
ELEILCEHAV NNVNEAVLAA RELIAEGPQV VLVKHLARAG YSPDRFEMLL
210 220 230 240 250
VTADEAWHIS RPLVDFGMRQ PVGVGDVTSG LLLVKLLQGA TLQQALEHVT
260 270 280
AAVYEIMIAT KNMQEYELQV VAAQDRIAKP EHYFSATQL
Length:289
Mass (Da):31,577
Last modified:October 23, 2007 - v1
Checksum:iB16B0C10B47DB238
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV12780.1.

Genome annotation databases

EnsemblBacteriaiABV12780; ABV12780; CKO_01648.
KEGGicko:CKO_01648.
PATRICi20386335. VBICitKos71230_1385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV12780.1.

3D structure databases

ProteinModelPortaliA8AH17.
SMRiA8AH17. Positions 4-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290338.CKO_01648.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV12780; ABV12780; CKO_01648.
KEGGicko:CKO_01648.
PATRICi20386335. VBICitKos71230_1385.

Phylogenomic databases

eggNOGiENOG4107XGF. Bacteria.
COG2240. LUCA.
HOGENOMiHOG000258173.
KOiK00868.
OMAiCPNQLEL.
OrthoDBiEOG69PQ1X.

Enzyme and pathway databases

UniPathwayiUPA01068; UER00298.
BioCyciCKOS290338:GJ8L-1645-MONOMER.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_01639. PdxY.
InterProiIPR013749. PM/HMP-P_kinase-1.
IPR004625. PyrdxlKinase.
IPR023685. Pyridoxal_kinase_PdxY.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR10534. PTHR10534. 1 hit.
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00687. pyridox_kin. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-895 / CDC 4225-83 / SGSC4696Imported.

Entry informationi

Entry nameiA8AH17_CITK8
AccessioniPrimary (citable) accession number: A8AH17
Entry historyi
Integrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: July 6, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.