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A8AGY5

- FOLM_CITK8

UniProt

A8AGY5 - FOLM_CITK8

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Protein
Dihydrofolate reductase FolM
Gene
folM, CKO_01615
Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reduction of dihydrofolate to tetrahydrofolate By similarity.

Catalytic activityi

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei152 – 1521Proton acceptor By similarity

GO - Molecular functioni

  1. dihydrofolate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. one-carbon metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciCKOS290338:GJ8L-1613-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrofolate reductase FolM (EC:1.5.1.3)
Short name:
DHFR
Gene namesi
Name:folM
Ordered Locus Names:CKO_01615
OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Taxonomic identifieri290338 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter
ProteomesiUP000008148: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Dihydrofolate reductase FolM
PRO_0000339388Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290338.CKO_01615.

Structurei

3D structure databases

ProteinModelPortaliA8AGY5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
KOiK13938.
OrthoDBiEOG6WDSG3.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8AGY5-1 [UniParc]FASTAAdd to Basket

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MGKNQPLPIL ITGGGRRIGL AIAWHFLNQK QPVIVSYRTH YPAIDGLTQA    50
GALCIQADFS TDDGVLAFAE KIKTHTPGLR AILHNASAWM AEAPGTPLSD 100
VLACMMQIHV NTPYLLNHAL ERLLRGHGHA ATDIIHFTDY VVERGSDKHI 150
AYAASKAALD NMTRSFARKL APEVKVNAIA PSLILFNEND DAEYRQQALN 200
KSLMKTAPGE KEVIDLVDYL LTSCFVTGRS FAVDGGRHLR 240
Length:240
Mass (Da):26,280
Last modified:June 10, 2008 - v2
Checksum:iA4DDBE321AD47257
GO

Sequence cautioni

The sequence ABV12747.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000822 Genomic DNA. Translation: ABV12747.1. Different initiation.
RefSeqiYP_001453184.1. NC_009792.1.

Genome annotation databases

EnsemblBacteriaiABV12747; ABV12747; CKO_01615.
GeneIDi5581133.
KEGGicko:CKO_01615.
PATRICi20386281. VBICitKos71230_1358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000822 Genomic DNA. Translation: ABV12747.1 . Different initiation.
RefSeqi YP_001453184.1. NC_009792.1.

3D structure databases

ProteinModelPortali A8AGY5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290338.CKO_01615.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV12747 ; ABV12747 ; CKO_01615 .
GeneIDi 5581133.
KEGGi cko:CKO_01615.
PATRICi 20386281. VBICitKos71230_1358.

Phylogenomic databases

eggNOGi COG1028.
KOi K13938.
OrthoDBi EOG6WDSG3.

Enzyme and pathway databases

BioCyci CKOS290338:GJ8L-1613-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-895 / CDC 4225-83 / SGSC4696.

Entry informationi

Entry nameiFOLM_CITK8
AccessioniPrimary (citable) accession number: A8AGY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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