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A8AGY5

- FOLM_CITK8

UniProt

A8AGY5 - FOLM_CITK8

Protein

Dihydrofolate reductase FolM

Gene

folM

Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 2 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the reduction of dihydrofolate to tetrahydrofolate.By similarity

    Catalytic activityi

    5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei152 – 1521Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. dihydrofolate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. one-carbon metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciCKOS290338:GJ8L-1613-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydrofolate reductase FolM (EC:1.5.1.3)
    Short name:
    DHFR
    Gene namesi
    Name:folM
    Ordered Locus Names:CKO_01615
    OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
    Taxonomic identifieri290338 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter
    ProteomesiUP000008148: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240Dihydrofolate reductase FolMPRO_0000339388Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290338.CKO_01615.

    Structurei

    3D structure databases

    ProteinModelPortaliA8AGY5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1028.
    KOiK13938.
    OrthoDBiEOG6WDSG3.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8AGY5-1 [UniParc]FASTAAdd to Basket

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    MGKNQPLPIL ITGGGRRIGL AIAWHFLNQK QPVIVSYRTH YPAIDGLTQA    50
    GALCIQADFS TDDGVLAFAE KIKTHTPGLR AILHNASAWM AEAPGTPLSD 100
    VLACMMQIHV NTPYLLNHAL ERLLRGHGHA ATDIIHFTDY VVERGSDKHI 150
    AYAASKAALD NMTRSFARKL APEVKVNAIA PSLILFNEND DAEYRQQALN 200
    KSLMKTAPGE KEVIDLVDYL LTSCFVTGRS FAVDGGRHLR 240
    Length:240
    Mass (Da):26,280
    Last modified:June 10, 2008 - v2
    Checksum:iA4DDBE321AD47257
    GO

    Sequence cautioni

    The sequence ABV12747.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000822 Genomic DNA. Translation: ABV12747.1. Different initiation.
    RefSeqiYP_001453184.1. NC_009792.1.

    Genome annotation databases

    EnsemblBacteriaiABV12747; ABV12747; CKO_01615.
    GeneIDi5581133.
    KEGGicko:CKO_01615.
    PATRICi20386281. VBICitKos71230_1358.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000822 Genomic DNA. Translation: ABV12747.1 . Different initiation.
    RefSeqi YP_001453184.1. NC_009792.1.

    3D structure databases

    ProteinModelPortali A8AGY5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290338.CKO_01615.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV12747 ; ABV12747 ; CKO_01615 .
    GeneIDi 5581133.
    KEGGi cko:CKO_01615.
    PATRICi 20386281. VBICitKos71230_1358.

    Phylogenomic databases

    eggNOGi COG1028.
    KOi K13938.
    OrthoDBi EOG6WDSG3.

    Enzyme and pathway databases

    BioCyci CKOS290338:GJ8L-1613-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-895 / CDC 4225-83 / SGSC4696.

    Entry informationi

    Entry nameiFOLM_CITK8
    AccessioniPrimary (citable) accession number: A8AGY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3