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A8AGY5 (FOLM_CITK8) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydrofolate reductase FolM

Short name=DHFR
EC=1.5.1.3
Gene names
Name:folM
Ordered Locus Names:CKO_01615
OrganismCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) [Complete proteome] [HAMAP]
Taxonomic identifier290338 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reduction of dihydrofolate to tetrahydrofolate By similarity.

Catalytic activity

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family. FolM subfamily.

Sequence caution

The sequence ABV12747.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processone-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiondihydrofolate reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 240240Dihydrofolate reductase FolM
PRO_0000339388

Sites

Active site1521Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
A8AGY5 [UniParc].

Last modified June 10, 2008. Version 2.
Checksum: A4DDBE321AD47257

FASTA24026,280
        10         20         30         40         50         60 
MGKNQPLPIL ITGGGRRIGL AIAWHFLNQK QPVIVSYRTH YPAIDGLTQA GALCIQADFS 

        70         80         90        100        110        120 
TDDGVLAFAE KIKTHTPGLR AILHNASAWM AEAPGTPLSD VLACMMQIHV NTPYLLNHAL 

       130        140        150        160        170        180 
ERLLRGHGHA ATDIIHFTDY VVERGSDKHI AYAASKAALD NMTRSFARKL APEVKVNAIA 

       190        200        210        220        230        240 
PSLILFNEND DAEYRQQALN KSLMKTAPGE KEVIDLVDYL LTSCFVTGRS FAVDGGRHLR 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000822 Genomic DNA. Translation: ABV12747.1. Different initiation.
RefSeqYP_001453184.1. NC_009792.1.

3D structure databases

ProteinModelPortalA8AGY5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290338.CKO_01615.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV12747; ABV12747; CKO_01615.
GeneID5581133.
KEGGcko:CKO_01615.
PATRIC20386281. VBICitKos71230_1358.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1028.
KOK13938.
OrthoDBEOG6WDSG3.
ProtClustDBPRK06483.

Enzyme and pathway databases

BioCycCKOS290338:GJ8L-1613-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOLM_CITK8
AccessionPrimary (citable) accession number: A8AGY5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 13, 2013
This is version 40 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families