Reviewed, UniProtKB/Swiss-Prot A8AGR0 (UXAB_CITK8)

Names and origin

Protein names

Recommended name:
    Altronate oxidoreductase
    EC=1.1.1.58
Alternative name(s):
    Tagaturonate reductase
    Tagaturonate dehydrogenase

Gene names

Name:	uxaB
Ordered Locus Names:	CKO_01541

Organism

Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) [Complete proteome] [HAMAP]

Taxonomic identifier

290338 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Citrobacter

Protein attributes

Sequence length	483 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-altronate + NAD+ = D-tagaturonate + NADH. HAMAP MF_00670
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00670
Sequence similarities	Belongs to the mannitol dehydrogenase family. UxaB subfamily.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro tagaturonate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 483	483	Altronate oxidoreductase HAMAP MF_00670		PRO_1000044701
Regions
	Nucleotide binding	18 – 29	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8AGR0-1 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 6680F00440B36A51	FASTA	483	54,486
	10 20 30 40 50 60 MKTLNRRDFP GASYPERIIQ FGEGNFLRAF VDWQVDLLNE HTDLNAGVVI VRPIESTFPP 70 80 90 100 110 120 SLSTQDGLYT TIIRGLNEKG EAVSDARLIR SVNREISVYD NYDEFLKLAH NPDMRFVFSN 130 140 150 160 170 180 TTEAGISYHA GDAFDDAPAV SYPAKLTRLL FERYTCFDGA LDKGWIIIPC ELIDYNGEAL 190 200 210 220 230 240 RELVLRYAQE WNLSAAFVQW LDQANTFCST LVDRIVTGYP RDEVTQLEAE LGYHDAFLDT 250 260 270 280 290 300 AEHFYLFVIQ GPKKVASELR LDKYPLNVLI VDDIKPYKER KVAILNGAHT ALVPVAFQAG 310 320 330 340 350 360 LDTVGEAMND RDICAFVEKA IYEEIIPVLD LPRDELMSFA SAVTGRFQNP YIKHQLLSIA 370 380 390 400 410 420 LNGMTKFRTR ILPQLLAGQQ VSGVLPARLT FALAALTAFY RGERRGETYP LQDDAHWIER 430 440 450 460 470 480 YQQLWHQHSD GLISTQDLVH AVLAVDAHWG QNLTHVAGLV EQVTTDLDAI LTKGMREAVK PLC

References

[1]	McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R. Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000822 Genomic DNA. Translation: ABV12673.1.
RefSeq	YP_001453109.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5581390.
GenomeReviews	Gene locus CKO_01541 in contig CP000822_GR.
KEGG	cko:CKO_01541.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A8AGR0. SIFPCEL.
Family and domain databases
HAMAP	MF_00670. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UXAB_CITK8

Accession

Primary (citable) accession number: A8AGR0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 23, 2007
Last modified:	June 16, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)