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Reviewed, UniProtKB/Swiss-Prot A8AGJ9 (ABDH_CITK8)

Last modified March 2, 2010. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
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Names and originHide

Protein namesRecommended name:
Gamma-aminobutyraldehyde dehydrogenase

EC=1.2.1.19
Alternative name(s):
1-pyrroline dehydrogenase
4-aminobutanal dehydrogenase
Short name=ABALDH
Gene names
Ordered Locus Names:CKO_01478
OrganismCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) [Complete proteome] [HAMAP]
Taxonomic identifier290338 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter
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Protein attributesHide

Sequence length474 AA.
Sequence statusComplete.
Protein existenceInferred from homology.
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General annotation (Comments)Hide

Function

Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4-aminobutanoate (GABA) By similarity. HAMAP MF_01275

Catalytic activity

4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH. HAMAP MF_01275

Pathway

Amine and polyamine degradation; putrescine degradation; 4-aminobutanoate from 4-aminobutanal: step 1/1. HAMAP MF_01275

Subunit structure

Homotetramer By similarity. HAMAP MF_01275

Miscellaneous

4-aminobutanal is also called gamma-aminobutyraldehyde. HAMAP MF_01275

Sequence similarities

Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.

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Sequence annotation (Features)Hide

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474Gamma-aminobutyraldehyde dehydrogenase HAMAP MF_01275
PRO_1000067390

Regions

Nucleotide binding172 – 1754NAD By similarity
Nucleotide binding225 – 2317NAD By similarity

Sites

Active site2461 By similarity
Active site2801Nucleophile By similarity
Binding site1461NAD; via carbonyl oxygen By similarity
Binding site2091NAD By similarity
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SequencesHide

Sequence LengthMass (Da)Tools
A8AGJ9-1 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: F9C378301CB80BF1

FASTA47450,950
        10         20         30         40         50         60 
MPHQLLINGE LVSGEGEKQP VYNPATGEVI LEIAEASPAQ VDAAVRAADR AFAEWGQTTP 

        70         80         90        100        110        120 
KARAELLLTL ADVIEENAQT FAELESQNCG KPLHCALNDE IPAIVDVFRF FAGAARCLNG 

       130        140        150        160        170        180 
LAAGEYLEGH TSMIRRDPVG VVASIAPWNY PLMMAAWKLA PALAAGNCVV IKPSEITPLT 

       190        200        210        220        230        240 
ALKLAEFAKD IFPPGVLNVL FGRGKTVGDP LTGHEKVRMV SLTGSIATGE HIIQHTAPSI 

       250        260        270        280        290        300 
KRTHMELGGK APVIVFDDAD LDAVVEGVRT FGFYNAGQDC TAACRIYAQK GIYDALVEKL 

       310        320        330        340        350        360 
GAAVASLKTG SPNDESTELG PLSSQAHLER VTKAVEEAKA LGHINVVTGG QKLDGAGYYF 

       370        380        390        400        410        420 
APTLLAGAKQ EDAIVQREVF GPVVSMTVFD DEEQVLAWAN DTQYGLASSV WTKDVGRAHR 

       430        440        450        460        470 
LSARLQYGCT WVNTHFMLVS EMPHGGQKRS GYGKDMSLYG LEDYTVIRHI MVKH 

« Hide

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ReferencesHide

[1]McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R.
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
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Cross-referencesHide

Sequence databases

EMBL
GenBank
DDBJ
CP000822 Genomic DNA. Translation: ABV12611.1.
RefSeqYP_001453048.1.

3D structure databases

SMRA8AGJ9. Positions 1-474.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8AGJ9.

Genome annotation databases

GeneID5581967.
GenomeReviewsGene locus CKO_01478 in contig CP000822_GR.
KEGGcko:CKO_01478.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHBG752218.
OMAQVLRWAN.
ProtClustDBPRK13473.

Family and domain databases

HAMAPMF_01275. Aldedh_YdcW.
[Tree]
InterProIPR017749. 1-pyrroline_dehydrogenase.
IPR016161. Ald_DH/histidinol_DH.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR03374. ABALDH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. False negative.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...
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Entry informationHide

Entry nameABDH_CITK8
AccessionPrimary (citable) accession number: A8AGJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: March 2, 2010
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)
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Relevant documentsHide

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents