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A8AFS1

- A8AFS1_CITK8

UniProt

A8AFS1 - A8AFS1_CITK8

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Protein
Alanine racemase
Gene
CKO_01194
Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei130 – 1301Substrate By similarityUniRule annotation
Active sitei253 – 2531Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei301 – 3011Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCKOS290338:GJ8L-1191-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:CKO_01194Imported
OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)Imported
Taxonomic identifieri290338 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter
ProteomesiUP000008148: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi290338.CKO_01194.

Structurei

3D structure databases

ProteinModelPortaliA8AFS1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031446.
KOiK01775.
OMAiPVELWGQ.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8AFS1-1 [UniParc]FASTAAdd to Basket

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MTRPILASLD LQAMKQNLGI VRQAAPDARV WSVVKANAYG HGIERIWTAL    50
GATDGFAMLN LEEAITLRER GWKGPILMLE GFFHADELAI YDTYRLTTCI 100
HSNWQLKVLQ NARLNAPLDV YLKVNSGMNR LGFLPERVQT VWQQLRALPN 150
VGEMTLMSHF ADAEHPEGID QAMTKIAHAT EGLECRRSLS NSAATLWHPE 200
AHFDWVRPGI ILYGASPSGQ WRDIANTGLK PVMTLSSQII GVQTLKAGDR 250
VGYGGRYTAT QEQRIGIVAA GYADGYPRHA PNGTPVLVDG VRTGTVGTVS 300
MDMLAVDLTP CPQAGIGTSV ELWGKEIKID DVASAAGTVG YELMCALAPR 350
VPVVTA 356
Length:356
Mass (Da):38,699
Last modified:October 23, 2007 - v1
Checksum:i0AFE27426AD68C45
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000822 Genomic DNA. Translation: ABV12334.1.
RefSeqiYP_001452770.1. NC_009792.1.

Genome annotation databases

EnsemblBacteriaiABV12334; ABV12334; CKO_01194.
GeneIDi5583102.
KEGGicko:CKO_01194.
PATRICi20385577. VBICitKos71230_1010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000822 Genomic DNA. Translation: ABV12334.1 .
RefSeqi YP_001452770.1. NC_009792.1.

3D structure databases

ProteinModelPortali A8AFS1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290338.CKO_01194.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV12334 ; ABV12334 ; CKO_01194 .
GeneIDi 5583102.
KEGGi cko:CKO_01194.
PATRICi 20385577. VBICitKos71230_1010.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031446.
KOi K01775.
OMAi PVELWGQ.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci CKOS290338:GJ8L-1191-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-895 / CDC 4225-83 / SGSC4696.

Entry informationi

Entry nameiA8AFS1_CITK8
AccessioniPrimary (citable) accession number: A8AFS1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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