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A8AF20 (GCH4_CITK8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:CKO_00933
OrganismCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) [Complete proteome] [HAMAP]
Taxonomic identifier290338 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000316529

Sites

Site1471May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
A8AF20 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 32FA670F3CDB92BC

FASTA29932,783
        10         20         30         40         50         60 
MLPDIQSTKG DGEGESLSWV GMEQIDLPID IAGRPVSAKV NAGINLLSSP EAEKGIHMSR 

        70         80         90        100        110        120 
LYLLLDELTQ GEITPALLQH VLKAFLVSHQ GRSDEASIEI SGDLLLSRKS LNSNHSGWKA 

       130        140        150        160        170        180 
YPLTLSAELR QSFTVTLKVG IPYSSTCPAS AALSRHVAGL QFSKDFGNRI DRLPAAEIAD 

       190        200        210        220        230        240 
WLVEKGMPAT PHSQRSWAWV SIRLNPEAKS LPVIELIDYA EVALGTAVQT VVKRSDEQAF 

       250        260        270        280        290 
AVANGQNLMF CEDAARRLNN VFRCAPFCEA FDIRVEHQES LHPHNAVARI HWKGSKNVT 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000822 Genomic DNA. Translation: ABV12083.1.
RefSeqYP_001452519.1. NC_009792.1.

3D structure databases

ProteinModelPortalA8AF20.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290338.CKO_00933.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV12083; ABV12083; CKO_00933.
GeneID5583976.
KEGGcko:CKO_00933.
PATRIC20385127. VBICitKos71230_0791.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000247517.
KOK09007.
OMAQNLMYVE.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycCKOS290338:GJ8L-932-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_CITK8
AccessionPrimary (citable) accession number: A8AF20
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways