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A8AF20

- GCH4_CITK8

UniProt

A8AF20 - GCH4_CITK8

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei147 – 1471May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCKOS290338:GJ8L-932-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:CKO_00933
OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Taxonomic identifieri290338 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter
ProteomesiUP000008148: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299GTP cyclohydrolase FolE2PRO_0000316529Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290338.CKO_00933.

Structurei

3D structure databases

ProteinModelPortaliA8AF20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiQNLMYVE.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8AF20-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPDIQSTKG DGEGESLSWV GMEQIDLPID IAGRPVSAKV NAGINLLSSP
60 70 80 90 100
EAEKGIHMSR LYLLLDELTQ GEITPALLQH VLKAFLVSHQ GRSDEASIEI
110 120 130 140 150
SGDLLLSRKS LNSNHSGWKA YPLTLSAELR QSFTVTLKVG IPYSSTCPAS
160 170 180 190 200
AALSRHVAGL QFSKDFGNRI DRLPAAEIAD WLVEKGMPAT PHSQRSWAWV
210 220 230 240 250
SIRLNPEAKS LPVIELIDYA EVALGTAVQT VVKRSDEQAF AVANGQNLMF
260 270 280 290
CEDAARRLNN VFRCAPFCEA FDIRVEHQES LHPHNAVARI HWKGSKNVT
Length:299
Mass (Da):32,783
Last modified:October 23, 2007 - v1
Checksum:i32FA670F3CDB92BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV12083.1.
RefSeqiYP_001452519.1. NC_009792.1.

Genome annotation databases

EnsemblBacteriaiABV12083; ABV12083; CKO_00933.
GeneIDi5583976.
KEGGicko:CKO_00933.
PATRICi20385127. VBICitKos71230_0791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV12083.1 .
RefSeqi YP_001452519.1. NC_009792.1.

3D structure databases

ProteinModelPortali A8AF20.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290338.CKO_00933.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV12083 ; ABV12083 ; CKO_00933 .
GeneIDi 5583976.
KEGGi cko:CKO_00933.
PATRICi 20385127. VBICitKos71230_0791.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi QNLMYVE.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci CKOS290338:GJ8L-932-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-895 / CDC 4225-83 / SGSC4696.

Entry informationi

Entry nameiGCH4_CITK8
AccessioniPrimary (citable) accession number: A8AF20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: October 1, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3