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A8AE87 (CDD_CITK8) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytidine deaminase
EC=3.5.4.5
Alternative name(s):
Cytidine aminohydrolase
Short name=CDA
Gene names
Name:cdd
Ordered Locus Names:CKO_00646
OrganismCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) [Complete proteome] [HAMAP]
Taxonomic identifier290338 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Citrobacter

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity. HAMAP MF_01558

Catalytic activity

Cytidine + H2O = uridine + NH3. HAMAP MF_01558

Cofactor

Binds 1 zinc ion By similarity. HAMAP MF_01558

Subunit structure

Homodimer By similarity. HAMAP MF_01558

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncytidine deaminase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Cytidine deaminase HAMAP MF_01558
PRO_1000068947

Regions

Region89 – 913Substrate binding By similarity

Sites

Active site1041Proton donor By similarity
Metal binding1021Zinc; catalytic By similarity
Metal binding1291Zinc; catalytic By similarity
Metal binding1321Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
A8AE87 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 6F8EEAE5A754AC6C

FASTA29431,732
        10         20         30         40         50         60 
MHPRFQTAFG QLADNLQSAL APILADEHFP AMLTAEQVST LKRESGLDED ALAFALLPLA 

        70         80         90        100        110        120 
AACARTDLSH FNVGAIARGI SGTWYFGGNM EFLGATMQQT VHAEQSAIGH AWLRGEKGLA 

       130        140        150        160        170        180 
AITVNYTPCG HCRQFMNELN SGLDLRIHLP GRVPHTLRDY LPDAFGPKDL EIKTLLMDEQ 

       190        200        210        220        230        240 
DHGFALEGDA LTQAAIAAAN KCHMPYSYSP SGVALECKDG RIFTGSYAEN AAFNPTLPPL 

       250        260        270        280        290 
QGALNLLNLN GYDYPDIQRA ILAEKADAPL IQWDATAATL KALGCNNIDR VLLG

« Hide

References

[1]The Citrobacter koseri Genome Sequencing Project
McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R.
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-895 / CDC 4225-83 / SGSC4696.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000822 Genomic DNA. Translation: ABV11800.1.
RefSeqYP_001452236.1. NC_009792.1.

3D structure databases

ProteinModelPortalA8AE87.
SMRA8AE87. Positions 1-294.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8AE87.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5583868.
GenomeReviewsGene locus CKO_00646 in contig CP000822_GR.
KEGGcko:CKO_00646.
PATRIC20384645. VBICitKos71230_0552.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0295.
HOGENOMHBG591160.
OMANRSHAPY.
ProtClustDBPRK09027.

Family and domain databases

HAMAPMF_01558. Cyt_deam.
[Tree]
InterProIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR013171. Cyd/dCyd_deaminase_Zn-bd.
IPR006263. Cyt_deam_dimer.
IPR016193. Cytidine_deaminase-like.
IPR020797. Cytidine_deaminase_bacteria.
[Graphical view]
KOK01489.
PANTHERPTHR11644:SF12. PTHR11644:SF12. 1 hit.
PfamPF00383. dCMP_cyt_deam_1. 1 hit.
PF08211. dCMP_cyt_deam_2. 1 hit.
[Graphical view]
PIRSFPIRSF006334. Cdd_plus_pseudo. 1 hit.
SUPFAMSSF53927. Cytidine_deaminase-like. 2 hits.
TIGRFAMsTIGR01355. Cyt_deam_dimer. 1 hit.
PROSITEPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDD_CITK8
AccessionPrimary (citable) accession number: A8AE87
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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