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A8AE79 (GCH1_CITK8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:CKO_00638
OrganismCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) [Complete proteome] [HAMAP]
Taxonomic identifier290338 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 222222GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_1000043677

Sites

Metal binding1111Zinc By similarity
Metal binding1141Zinc By similarity
Metal binding1821Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
A8AE79 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: C603256C64A858DC

FASTA22224,887
        10         20         30         40         50         60 
MSSLSKEAAL VHEALVARGL ETPLRPPVHE MDNETRKRLI SGHMTEIMQL LNLDLSDDSL 

        70         80         90        100        110        120 
METPHRIAKM YVDEIFSGLD YANFPKITVI ENKMKVDEMV TVRDITLTST CEHHFVTIDG 

       130        140        150        160        170        180 
KATVAYIPKD SVIGLSKINR IVQFFAQRPQ VQERLTQQIL TALQTLLGTN NVAVSIDAVH 

       190        200        210        220 
YCVKARGIRD ATSATTTTSL GGLFKSSQNT RQEFLRAVRH HN 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000822 Genomic DNA. Translation: ABV11792.1.
RefSeqYP_001452228.1. NC_009792.1.

3D structure databases

ProteinModelPortalA8AE79.
SMRA8AE79. Positions 3-222.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290338.CKO_00638.

Proteomic databases

PRIDEA8AE79.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV11792; ABV11792; CKO_00638.
GeneID5584988.
KEGGcko:CKO_00638.
PATRIC20384629. VBICitKos71230_0544.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAVQFFSSR.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

BioCycCKOS290338:GJ8L-638-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_CITK8
AccessionPrimary (citable) accession number: A8AE79
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways