ID   A8ACV4_CITK8            Unreviewed;       871 AA.
AC   A8ACV4;
DT   23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   23-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   RecName: Full=Adenylate cyclase {ECO:0000256|ARBA:ARBA00021420, ECO:0000256|RuleBase:RU000604};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201, ECO:0000256|RuleBase:RU000604};
GN   OrderedLocusNames=CKO_00148 {ECO:0000313|EMBL:ABV11317.1};
OS   Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Citrobacter.
OX   NCBI_TaxID=290338 {ECO:0000313|EMBL:ABV11317.1, ECO:0000313|Proteomes:UP000008148};
RN   [1] {ECO:0000313|EMBL:ABV11317.1, ECO:0000313|Proteomes:UP000008148}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-895 / CDC 4225-83 / SGSC4696
RC   {ECO:0000313|Proteomes:UP000008148};
RG   The Citrobacter koseri Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA   Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W.,
RA   Johnson M., Thiruvilangam P., Wilson R.;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001593,
CC         ECO:0000256|RuleBase:RU000604};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|RuleBase:RU000604}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family.
CC       {ECO:0000256|ARBA:ARBA00007901, ECO:0000256|RuleBase:RU004184}.
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DR   EMBL; CP000822; ABV11317.1; -; Genomic_DNA.
DR   AlphaFoldDB; A8ACV4; -.
DR   STRING; 290338.CKO_00148; -.
DR   KEGG; cko:CKO_00148; -.
DR   HOGENOM; CLU_013280_0_0_6; -.
DR   Proteomes; UP000008148; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024686; Adenylate_cyclase_1_CS.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   PANTHER; PTHR38760; ADENYLATE CYCLASE; 1.
DR   PANTHER; PTHR38760:SF1; ADENYLATE CYCLASE; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   PIRSF; PIRSF001444; Adenylate_cycl; 1.
DR   PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1.
DR   PROSITE; PS01093; ADENYLATE_CYCLASE_1_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998,
KW   ECO:0000256|RuleBase:RU000604}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000604};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008148}.
FT   DOMAIN          28..223
FT                   /note="Adenylate cyclase class-I N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12633"
SQ   SEQUENCE   871 AA;  100038 MW;  206F84BC79DA0BE0 CRC64;
     MVWLSALAMA IRRMTGSNIR RYVLYLYIET LKQRLDAINQ LRVDRALAAM GPAFQQVYSL
     LPTLLHYHNP LMPGYLDGNV PKGICFYTPD ETQRHYLNEL ELYRGMSPQD PPKGELPITG
     VYSMGSTSSV GQSCSSDLDI WVCHQSWLDS EERQLLQRKC SLLESWAASL GVEVSFFLID
     ENRFRHNESG SLGGEDCGST QHILLLDEFY RTAVRLAGKR ILWNMVPCDE EEHYDDYVMT
     LYAQGVLTPN EWLDLGGLSS LSAEEYFGAS LWQLYKSIDS PYKAVLKTLL LEAYSWEYPN
     PRLLAKDIKQ RLHDGEIVSF GLDPYCMMLE RVTEYLTAIE DPTRLDLVRR CFYLKVCEKL
     SRERACVGWR REVLSQLVNE WGWDDARLTM LDNRANWKID QVREAHNELL DAMMQSYRNL
     IRFARRNNLS VSASPQDIGV LTRKLYAAFE ALPGKVTLVN PQISPDLSEP NLTFIHVPPG
     RANRSGWYLY NRAPNMDSII SHQPLEYNRY LNKLVAWAWF NGLLTSRTHL FIKGNGIVDL
     PKLQEMVADV SHHFPLRLPA PTPKALYSPC EIRHLAIIVN LEYDPTAAFR NQVVHFDFRK
     LDVFSFGEEQ NCLVGSVDLL YRNSWNEVRT LHFNGEQAMI EALKTILGKM HQDAAPPDSV
     EVFCYSQHLR GLIRTRVQQL VSECIELRLS STRQETGRFK ALRVSGQTWG LFFERLNVSV
     QKLENAIEFY GAISHNKLHG LSVQVETNHV KLPSVVDGFA SEGIIQFFFE ETGDEKGFNI
     YILDESNRAE VYHHCEGSKE ELVRDVSRFY SSSHDRFTYG SSFINFNLPQ FYQIVNTDGR
     EQVIPFRTQP ISAVPPANQD NDAPLLQQYF S
//