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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi: ppGpp biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes ppGpp from GTP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA)
This subpathway is part of the pathway ppGpp biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ppGpp from GTP, the pathway ppGpp biosynthesis and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00908; UER00885

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:CKO_00121
OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Taxonomic identifieri290338 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCitrobacter
Proteomesi
  • UP000008148 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000688201 – 494Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseAdd BLAST494

Proteomic databases

PRIDEiA8ACT2

Interactioni

Protein-protein interaction databases

STRINGi290338.CKO_00121

Structurei

3D structure databases

ProteinModelPortaliA8ACT2
SMRiA8ACT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9X Bacteria
COG0248 LUCA
HOGENOMiHOG000258672
KOiK01524
OMAiWQICVGA
OrthoDBiPOG091H00D6

Family and domain databases

HAMAPiMF_01550 GppA, 1 hit
InterProiView protein in InterPro
IPR023709 Guo-5TP_3DP_PyrP
IPR003695 Ppx_GppA
IPR030673 PyroPPase_GppA_Ppx
PfamiView protein in Pfam
PF02541 Ppx-GppA, 1 hit
PIRSFiPIRSF001267 Pyrophosphatase_GppA_Ppx, 1 hit

Sequencei

Sequence statusi: Complete.

A8ACT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTSTSLYAA IDLGSNSFHM LVVREVAGSI QTLTRIKRKV RLAAGLNSDN
60 70 80 90 100
SLSAEAMERG WQCLRLFAER LQDIPQPQIC VVATATLRLA VNAGEFIAKA
110 120 130 140 150
QEILGCPVQV ISGEEEARLI YQGVAHTTGG ADQRLVVDIG GASTELVTGT
160 170 180 190 200
GAQTTSLFSL SMGCVTWLER YFTDRNLAQE NFDEAEKAAR EVLRPVADEL
210 220 230 240 250
RKHGWKVCVG ASGTVQALQE IMMAQGMDER ITLAKLQQLK QRAIHCGRLE
260 270 280 290 300
ELEIEGLTLE RALVFPSGLA ILIAIFTELD IQCMTLAGGA LREGLVYGML
310 320 330 340 350
HLAVDQDIRS RTLRNIQRRF MVDTEQAHRV ADLAVNFLDQ VEDKWHLEPI
360 370 380 390 400
SRELLTSACQ LHEIGLSVDF KQAPQHAAYL VRNLDLPGFT PAQKKLLATL
410 420 430 440 450
LLNQTNPIDL SSLHQQNAVP PRVAEHLCRL LRLAIIFASR RRDDLVPQIT
460 470 480 490
LQAQDENLTL TLPQGWLEHH PLGKELIDQE SQWQSYVHWP LDVH
Length:494
Mass (Da):54,996
Last modified:October 23, 2007 - v1
Checksum:i9436BA07489D69C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA Translation: ABV11295.1
RefSeqiWP_012131131.1, NC_009792.1

Genome annotation databases

EnsemblBacteriaiABV11295; ABV11295; CKO_00121
KEGGicko:CKO_00121

Entry informationi

Entry nameiGPPA_CITK8
AccessioniPrimary (citable) accession number: A8ACT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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