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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCKOS290338:GJ8L-121-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:CKO_00121
OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Taxonomic identifieri290338 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter
ProteomesiUP000008148 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_1000068820Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290338.CKO_00121.

Structurei

3D structure databases

ProteinModelPortaliA8ACT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiFKRAPQH.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
IPR030673. PyroPPase_GppA_Ppx.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
PIRSFiPIRSF001267. Pyrophosphatase_GppA_Ppx. 1 hit.

Sequencei

Sequence statusi: Complete.

A8ACT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTSTSLYAA IDLGSNSFHM LVVREVAGSI QTLTRIKRKV RLAAGLNSDN
60 70 80 90 100
SLSAEAMERG WQCLRLFAER LQDIPQPQIC VVATATLRLA VNAGEFIAKA
110 120 130 140 150
QEILGCPVQV ISGEEEARLI YQGVAHTTGG ADQRLVVDIG GASTELVTGT
160 170 180 190 200
GAQTTSLFSL SMGCVTWLER YFTDRNLAQE NFDEAEKAAR EVLRPVADEL
210 220 230 240 250
RKHGWKVCVG ASGTVQALQE IMMAQGMDER ITLAKLQQLK QRAIHCGRLE
260 270 280 290 300
ELEIEGLTLE RALVFPSGLA ILIAIFTELD IQCMTLAGGA LREGLVYGML
310 320 330 340 350
HLAVDQDIRS RTLRNIQRRF MVDTEQAHRV ADLAVNFLDQ VEDKWHLEPI
360 370 380 390 400
SRELLTSACQ LHEIGLSVDF KQAPQHAAYL VRNLDLPGFT PAQKKLLATL
410 420 430 440 450
LLNQTNPIDL SSLHQQNAVP PRVAEHLCRL LRLAIIFASR RRDDLVPQIT
460 470 480 490
LQAQDENLTL TLPQGWLEHH PLGKELIDQE SQWQSYVHWP LDVH
Length:494
Mass (Da):54,996
Last modified:October 23, 2007 - v1
Checksum:i9436BA07489D69C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV11295.1.
RefSeqiWP_012131131.1. NC_009792.1.

Genome annotation databases

EnsemblBacteriaiABV11295; ABV11295; CKO_00121.
KEGGicko:CKO_00121.
PATRICi20383712. VBICitKos71230_0102.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA. Translation: ABV11295.1.
RefSeqiWP_012131131.1. NC_009792.1.

3D structure databases

ProteinModelPortaliA8ACT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290338.CKO_00121.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV11295; ABV11295; CKO_00121.
KEGGicko:CKO_00121.
PATRICi20383712. VBICitKos71230_0102.

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiFKRAPQH.
OrthoDBiEOG6M6JN6.

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.
BioCyciCKOS290338:GJ8L-121-MONOMER.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
IPR030673. PyroPPase_GppA_Ppx.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
PIRSFiPIRSF001267. Pyrophosphatase_GppA_Ppx. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-895 / CDC 4225-83 / SGSC4696.

Entry informationi

Entry nameiGPPA_CITK8
AccessioniPrimary (citable) accession number: A8ACT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: May 27, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.