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A8ACT2 (GPPA_CITK8) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:CKO_00121
OrganismCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) [Complete proteome] [HAMAP]
Taxonomic identifier290338 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_1000068820

Sequences

Sequence LengthMass (Da)Tools
A8ACT2 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 9436BA07489D69C0

FASTA49454,996
        10         20         30         40         50         60 
MLTSTSLYAA IDLGSNSFHM LVVREVAGSI QTLTRIKRKV RLAAGLNSDN SLSAEAMERG 

        70         80         90        100        110        120 
WQCLRLFAER LQDIPQPQIC VVATATLRLA VNAGEFIAKA QEILGCPVQV ISGEEEARLI 

       130        140        150        160        170        180 
YQGVAHTTGG ADQRLVVDIG GASTELVTGT GAQTTSLFSL SMGCVTWLER YFTDRNLAQE 

       190        200        210        220        230        240 
NFDEAEKAAR EVLRPVADEL RKHGWKVCVG ASGTVQALQE IMMAQGMDER ITLAKLQQLK 

       250        260        270        280        290        300 
QRAIHCGRLE ELEIEGLTLE RALVFPSGLA ILIAIFTELD IQCMTLAGGA LREGLVYGML 

       310        320        330        340        350        360 
HLAVDQDIRS RTLRNIQRRF MVDTEQAHRV ADLAVNFLDQ VEDKWHLEPI SRELLTSACQ 

       370        380        390        400        410        420 
LHEIGLSVDF KQAPQHAAYL VRNLDLPGFT PAQKKLLATL LLNQTNPIDL SSLHQQNAVP 

       430        440        450        460        470        480 
PRVAEHLCRL LRLAIIFASR RRDDLVPQIT LQAQDENLTL TLPQGWLEHH PLGKELIDQE 

       490 
SQWQSYVHWP LDVH 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000822 Genomic DNA. Translation: ABV11295.1.
RefSeqYP_001451731.1. NC_009792.1.

3D structure databases

ProteinModelPortalA8ACT2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290338.CKO_00121.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV11295; ABV11295; CKO_00121.
GeneID5582872.
KEGGcko:CKO_00121.
PATRIC20383712. VBICitKos71230_0102.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OMAPPRVAEH.
OrthoDBEOG6M6JN6.
ProtClustDBPRK11031.

Enzyme and pathway databases

BioCycCKOS290338:GJ8L-121-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPPA_CITK8
AccessionPrimary (citable) accession number: A8ACT2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: February 19, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways