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Protein

Transcription initiation factor IIB

Gene

tfb

Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi11ZincUniRule annotation1
Metal bindingi14ZincUniRule annotation1
Metal bindingi30ZincUniRule annotation1
Metal bindingi33ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 38TFIIB-typeUniRule annotationAdd BLAST32

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciIHOS453591:G1G9W-1435-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIBUniRule annotation
Short name:
TFIIBUniRule annotation
Gene namesi
Name:tfbUniRule annotation
Ordered Locus Names:Igni_1372
OrganismiIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Taxonomic identifieri453591 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus
Proteomesi
  • UP000000262 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000801051 – 316Transcription initiation factor IIBAdd BLAST316

Proteomic databases

PRIDEiA8AC96

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi453591.Igni_1372

Structurei

3D structure databases

ProteinModelPortaliA8AC96
SMRiA8AC96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati124 – 2071Add BLAST84
Repeati218 – 2992Add BLAST82

Sequence similaritiesi

Belongs to the TFIIB family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 38TFIIB-typeUniRule annotationAdd BLAST32

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiarCOG01981 Archaea
COG1405 LUCA
HOGENOMiHOG000108633
KOiK03124
OMAiNDDQGND
OrthoDBiPOG093Z07LX

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
HAMAPiMF_00383 TF2B_arch, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR000812 TFIIB
IPR023484 TFIIB_arc
IPR023486 TFIIB_CS
IPR013150 TFIIB_cyclin
IPR013137 Znf_TFIIB
PANTHERiPTHR11618 PTHR11618, 1 hit
PfamiView protein in Pfam
PF08271 TF_Zn_Ribbon, 1 hit
PF00382 TFIIB, 2 hits
PRINTSiPR00685 TIFACTORIIB
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00782 TFIIB, 1 hit
PS51134 ZF_TFIIB, 1 hit

Sequencei

Sequence statusi: Complete.

A8AC96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEQEAFRLR CPVCGSTDIV FNEETGEYVC ARCGTIVLDR YVDQGPEWRA
60 70 80 90 100
FTPEERERRG RTGAPLSPTL HDHGLSTVID HRDRDALGKR LSPRKRQEVQ
110 120 130 140 150
RLRKWQLRAR IQTGMDRNLT IAMNELDRMA NLLNLPKQIK EEAAVIYRKA
160 170 180 190 200
VEKGLVRGRS IESVVAAVIY AACRIHHQPR TLDEIAKKLE VNRKEVARCY
210 220 230 240 250
RLITKELKLK VPIADAMDHI PRIGEALKLR GDIIEYAMKI MEKIKGHPIT
260 270 280 290 300
AGKDPAGIAA AVIYIAVMQK GERRTQKEIA NVAGVTEVTV RNRYKEIMKV
310
LNEMDLEEIE KEVSKK
Length:316
Mass (Da):36,094
Last modified:October 23, 2007 - v1
Checksum:iD3CF0714EAC2E453
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000816 Genomic DNA Translation: ABU82548.1
RefSeqiWP_012123512.1, NC_009776.1

Genome annotation databases

EnsemblBacteriaiABU82548; ABU82548; Igni_1372
GeneIDi5562291
KEGGiiho:Igni_1372

Similar proteinsi

Entry informationi

Entry nameiTF2B_IGNH4
AccessioniPrimary (citable) accession number: A8AC96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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