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A8AC96

- TF2B_IGNH4

UniProt

A8AC96 - TF2B_IGNH4

Protein

Transcription initiation factor IIB

Gene

tfb

Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi11 – 111ZincUniRule annotation
    Metal bindingi14 – 141ZincUniRule annotation
    Metal bindingi30 – 301ZincUniRule annotation
    Metal bindingi33 – 331ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri7 – 3832TFIIB-typeUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA-templated transcription, initiation Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciIHOS453591:GHYN-1416-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription initiation factor IIBUniRule annotation
    Short name:
    TFIIBUniRule annotation
    Gene namesi
    Name:tfbUniRule annotation
    Ordered Locus Names:Igni_1372
    OrganismiIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
    Taxonomic identifieri453591 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus
    ProteomesiUP000000262: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Transcription initiation factor IIBPRO_1000080105Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi453591.Igni_1372.

    Structurei

    3D structure databases

    ProteinModelPortaliA8AC96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati124 – 207841Add
    BLAST
    Repeati218 – 299822Add
    BLAST

    Sequence similaritiesi

    Belongs to the TFIIB family.UniRule annotation
    Contains 1 TFIIB-type zinc finger.UniRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri7 – 3832TFIIB-typeUniRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1405.
    HOGENOMiHOG000108633.
    KOiK03124.
    OMAiCGNDKFV.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    HAMAPiMF_00383. TF2B_arch.
    InterProiIPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR023484. TFIIB_arc.
    IPR023486. TFIIB_CS.
    IPR013150. TFIIB_cyclin.
    IPR013137. Znf_TFIIB.
    [Graphical view]
    PANTHERiPTHR11618. PTHR11618. 1 hit.
    PfamiPF08271. TF_Zn_Ribbon. 1 hit.
    PF00382. TFIIB. 2 hits.
    [Graphical view]
    PRINTSiPR00685. TIFACTORIIB.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00782. TFIIB. 1 hit.
    PS51134. ZF_TFIIB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8AC96-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPEQEAFRLR CPVCGSTDIV FNEETGEYVC ARCGTIVLDR YVDQGPEWRA    50
    FTPEERERRG RTGAPLSPTL HDHGLSTVID HRDRDALGKR LSPRKRQEVQ 100
    RLRKWQLRAR IQTGMDRNLT IAMNELDRMA NLLNLPKQIK EEAAVIYRKA 150
    VEKGLVRGRS IESVVAAVIY AACRIHHQPR TLDEIAKKLE VNRKEVARCY 200
    RLITKELKLK VPIADAMDHI PRIGEALKLR GDIIEYAMKI MEKIKGHPIT 250
    AGKDPAGIAA AVIYIAVMQK GERRTQKEIA NVAGVTEVTV RNRYKEIMKV 300
    LNEMDLEEIE KEVSKK 316
    Length:316
    Mass (Da):36,094
    Last modified:October 23, 2007 - v1
    Checksum:iD3CF0714EAC2E453
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000816 Genomic DNA. Translation: ABU82548.1.
    RefSeqiWP_012123512.1. NC_009776.1.
    YP_001435955.1. NC_009776.1.

    Genome annotation databases

    EnsemblBacteriaiABU82548; ABU82548; Igni_1372.
    GeneIDi5562291.
    KEGGiiho:Igni_1372.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000816 Genomic DNA. Translation: ABU82548.1 .
    RefSeqi WP_012123512.1. NC_009776.1.
    YP_001435955.1. NC_009776.1.

    3D structure databases

    ProteinModelPortali A8AC96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 453591.Igni_1372.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU82548 ; ABU82548 ; Igni_1372 .
    GeneIDi 5562291.
    KEGGi iho:Igni_1372.

    Phylogenomic databases

    eggNOGi COG1405.
    HOGENOMi HOG000108633.
    KOi K03124.
    OMAi CGNDKFV.

    Enzyme and pathway databases

    BioCyci IHOS453591:GHYN-1416-MONOMER.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    HAMAPi MF_00383. TF2B_arch.
    InterProi IPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR023484. TFIIB_arc.
    IPR023486. TFIIB_CS.
    IPR013150. TFIIB_cyclin.
    IPR013137. Znf_TFIIB.
    [Graphical view ]
    PANTHERi PTHR11618. PTHR11618. 1 hit.
    Pfami PF08271. TF_Zn_Ribbon. 1 hit.
    PF00382. TFIIB. 2 hits.
    [Graphical view ]
    PRINTSi PR00685. TIFACTORIIB.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00782. TFIIB. 1 hit.
    PS51134. ZF_TFIIB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIN4/I / DSM 18386 / JCM 14125.

    Entry informationi

    Entry nameiTF2B_IGNH4
    AccessioniPrimary (citable) accession number: A8AC96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3