A8AC76 (A8AC76_IGNH4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase III HAMAP-Rule MF_00608
EC=3.5.4.29 HAMAP-Rule MF_00608

Gene names

Name:	gch3 HAMAP-Rule MF_00608
Ordered Locus Names:	Igni_1352

Organism

Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) [Complete proteome] [HAMAP] EMBL ABU82528.1

Taxonomic identifier

453591 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Ignicoccus › Ignicoccus hospitalis

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity By similarity. HAMAP-Rule MF_00608
Catalytic activity	GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 phosphate. HAMAP-Rule MF_00608
Sequence similarities	Belongs to the archaeal-type GTP cyclohydrolase family. HAMAP-Rule MF_00608

Ontologies

Keywords
Ligand	GTP-binding HAMAP-Rule MF_00608 Nucleotide-binding
Molecular function	Hydrolase HAMAP-Rule MF_00608 EMBL ABU82528.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase IIa activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8AC76 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 4B806513282BDB21	FASTA	214	23,505
	10 20 30 40 50 60 MHKVASVVLE GYREWTESLG DDREWKIQLK QAEIDMVATR AAKDVGAFYI PTRKDVLFFV 70 80 90 100 110 120 LNGVEDPAPI FEEVSKVSPV PISVVVGCGR TPLAALNSRE TCKVTSNIAA IHIDINFFRT 130 140 150 160 170 180 RDKYLGFVES VDLLDDILKI GIGYGSIGTY LGGDNIVMFS DPSAAGELAR LISSFYDVKV 190 200 210 GVGIDKTPRG ALELAARALR LLREDRTSKV IILK

References

[1]

"A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitans." Podar M., Anderson I., Makarova K.S., Elkins J.G., Ivanova N., Wall M.A., Lykidis A., Mavromatis K., Sun H., Hudson M.E., Chen W., Deciu C., Hutchison D., Eads J.R., Anderson A., Fernandes F., Szeto E., Lapidus A. , Kyrpides N.C., Saier M.H. Jr., Richardson P.M., Rachel R., Huber H., Eisen J.A., Koonin E.V., Keller M., Stetter K.O. Genome Biol. 9:R158.1-R158.18(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIN4/I / DSM 18386 / JCM 14125.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000816 Genomic DNA. Translation: ABU82528.1.
RefSeq	YP_001435935.1. NC_009776.1.
3D structure databases
ProteinModelPortal	A8AC76.
ModBase	Search...
Protein-protein interaction databases
STRING	453591.Igni_1352.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABU82528; ABU82528; Igni_1352.
GeneID	5563062.
KEGG	iho:Igni_1352.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2429.
HOGENOM	HOG000222345.
KO	K08096.
OMA	DREWKIQ.
Enzyme and pathway databases
BioCyc	IHOS453591:GHYN-1402-MONOMER.
Family and domain databases
HAMAP	MF_00608. GTP_cyclohydro_3.
InterPro	IPR007839. GTP_CycHdrlase_3. [Graphical view]
Pfam	PF05165. GGDN. 2 hits. [Graphical view]
ProDom	PD313320. GTP_CycHdrlase_3. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

A8AC76_IGNH4

Accession

Primary (citable) accession number: A8AC76

Entry history

Integrated into UniProtKB/TrEMBL:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	May 1, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)