A8AC12 (A8AC12_IGNH4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Probable 3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210
EC=2.5.1.19 HAMAP MF_00210

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase HAMAP MF_00210

Gene names

Name:	aroA HAMAP MF_00210
Ordered Locus Names:	Igni_1288

Organism

Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) [Complete proteome] [HAMAP]

Taxonomic identifier

453591 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Ignicoccus

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family. HAMAP MF_00210

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00210
Cellular component	Cytoplasm HAMAP MF_00210
Molecular function	Transferase HAMAP MF_00210 EMBL ABU82464.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8AC12 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: BE5A3A2162EE1137	FASTA	443	46,506
	10 20 30 40 50 60 MLNTPALTDG PCEGKRNLRV RVEPSTPEGS VEAPPSKSWA QRAAFLALLA EGRSSFRRVP 70 80 90 100 110 120 ESDDVLASLE AVRAFGAKVE AKGGEVAIEG GEVKVPEDVI NMRGSGTGAR IAIAVGTLVP 130 140 150 160 170 180 KGFGVVVTGN ASLRRRPMTP VVEVMNALGA EVVSLRGGLL PVVSFGGLPG GEAEVDGSVT 190 200 210 220 230 240 SQHVTAALIA STKSERGAKI TVKNAVSRGY IALTERVMRL FGAKVKCDAK YSYCEVEPSE 250 260 270 280 290 300 LKAVRSEVPG DYALAAFPAA LAVVSGGEVK VGPLPPPESG PGDHRLVDYL RKFGVEVSYS 310 320 330 340 350 360 DGYLRVEGSV RPKGTRVNLK DEPDLALPLA AVAAVSKGES VLAGLSHLVY KESNRIETIL 370 380 390 400 410 420 QTLKCFGVSA RVDGPSIRVL GTESLRPCRL KCPDDHRIAM LAAVLGSAAG AVIESAECVN 430 440 KSWPGFWDAL SSLGVKVYVE GRR

References

[1]

"A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitans." Podar M., Anderson I., Makarova K.S., Elkins J.G., Ivanova N., Wall M.A., Lykidis A., Mavromatis K., Sun H., Hudson M.E., Chen W., Deciu C., Hutchison D., Eads J.R., Anderson A., Fernandes F., Szeto E., Lapidus A. , Kyrpides N.C., Saier M.H. Jr., Richardson P.M., Rachel R., Huber H., Eisen J.A., Koonin E.V., Keller M., Stetter K.O. Genome Biol. 9:R158.1-R158.18(2008) [PubMed: 19000309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000816 Genomic DNA. Translation: ABU82464.1.
RefSeq	YP_001435871.1. NC_009776.1.
3D structure databases
ProteinModelPortal	A8AC12.
ModBase	Search...
Protein-protein interaction databases
STRING	A8AC12.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5562186.
GenomeReviews	Gene locus Igni_1288 in contig CP000816_GR.
KEGG	iho:Igni_1288.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05032.
HOGENOM	HBG646626.
OMA	ERKSWSF.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A8AC12_IGNH4

Accession

Primary (citable) accession number: A8AC12

Entry history

Integrated into UniProtKB/TrEMBL:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	November 16, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)