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A8ABI5

- SYE_IGNH4

UniProt

A8ABI5 - SYE_IGNH4

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Protein
Glutamate--tRNA ligase
Gene
gltX, Igni_1110
Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciIHOS453591:GHYN-1141-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Gene namesi
Name:gltX
Ordered Locus Names:Igni_1110
OrganismiIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Taxonomic identifieri453591 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus
ProteomesiUP000000262: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Glutamate--tRNA ligaseUniRule annotation
PRO_1000070998Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi453591.Igni_1110.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi104 – 11411"HIGH" regionUniRule annotation
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000073585.
KOiK01885.
OMAiAFRIIDT.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_A. Glu_tRNA_synth_A.
InterProiIPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00463. gltX_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

A8ABI5-1 [UniParc]FASTAAdd to Basket

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MDVRELALKH ALRNAYLHGG KAQLKPVVTA VLAESPELRP KVKEIIPIIK    50
EVVEEVNRMS LEEQERILKE RFPEALEERK KETRKGLPPL PNAERGKVKT 100
RFAPNPDFYM TLGNARPAII SYEYAKAYEG RFVLRFEDTD PRTKRPLPEA 150
YEAIKEDLSW LGIGWDEEYY QSQRMEVYYG LLRELVRRGG AYVCTCPPEE 200
WRKLRDEGKP CPHRDLPPEE QEELLDQVLE GKFGEGEAVV RVKTDLRHPD 250
PSVRDWVAFR IIDTSKHPHP LTGDKYVLWP TYNFAAGVDD YLMGITHVLR 300
AREHRQNTVK QEFLYKHLGW TMPTVIHFGR LKLEGFVLSK SKMREAGFKG 350
DDPRAATIRG LRRRGFAPEA IREVMLSVGI KSSDASISFA NLAAENKKVI 400
DKKAYRVMAV EDPAPAKLLA PEPLEAELPW HPTEGLGSRK YSVEPGEVVY 450
LERADLRRAK RRGGLRLMEL ANFKYKGFDE DEGVYLLEFE SKELDKEKGY 500
DIVQWVKDPK GAIVWRPGER KSFALVEPEA LKLEGWVQLI RKGYAKVDGV 550
EEDTLNLIYL HE 562
Length:562
Mass (Da):64,685
Last modified:October 23, 2007 - v1
Checksum:i1416697F0F34CB10
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000816 Genomic DNA. Translation: ABU82287.1.
RefSeqiWP_012123251.1. NC_009776.1.
YP_001435694.1. NC_009776.1.

Genome annotation databases

EnsemblBacteriaiABU82287; ABU82287; Igni_1110.
GeneIDi5562106.
KEGGiiho:Igni_1110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000816 Genomic DNA. Translation: ABU82287.1 .
RefSeqi WP_012123251.1. NC_009776.1.
YP_001435694.1. NC_009776.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 453591.Igni_1110.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU82287 ; ABU82287 ; Igni_1110 .
GeneIDi 5562106.
KEGGi iho:Igni_1110.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000073585.
KOi K01885.
OMAi AFRIIDT.

Enzyme and pathway databases

BioCyci IHOS453591:GHYN-1141-MONOMER.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_A. Glu_tRNA_synth_A.
InterProi IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF50715. SSF50715. 1 hit.
TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIN4/I / DSM 18386 / JCM 14125.

Entry informationi

Entry nameiSYE_IGNH4
AccessioniPrimary (citable) accession number: A8ABI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 23, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi