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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciIHOS453591:G1G9W-1152-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Igni_1110
OrganismiIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Taxonomic identifieri453591 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus
Proteomesi
  • UP000000262 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000709981 – 562Glutamate--tRNA ligaseAdd BLAST562

Proteomic databases

PRIDEiA8ABI5

Interactioni

Protein-protein interaction databases

STRINGi453591.Igni_1110

Structurei

3D structure databases

SMRiA8ABI5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi104 – 114"HIGH" regionUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04302 Archaea
COG0008 LUCA
HOGENOMiHOG000073585
KOiK01885
OMAiMRFAPNP
OrthoDBiPOG093Z013J

Family and domain databases

Gene3Di2.40.240.10, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_02076 Glu_tRNA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR004526 Glu-tRNA-synth_arc/euk
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020059 Glu/Gln-tRNA-synth_Ib_codon-bd
IPR020056 Rbsml_L25/Gln-tRNA_synth_N
IPR011035 Ribosomal_L25/Gln-tRNA_synth
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PF03950 tRNA-synt_1c_C, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF50715 SSF50715, 1 hit
TIGRFAMsiTIGR00463 gltX_arch, 1 hit

Sequencei

Sequence statusi: Complete.

A8ABI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVRELALKH ALRNAYLHGG KAQLKPVVTA VLAESPELRP KVKEIIPIIK
60 70 80 90 100
EVVEEVNRMS LEEQERILKE RFPEALEERK KETRKGLPPL PNAERGKVKT
110 120 130 140 150
RFAPNPDFYM TLGNARPAII SYEYAKAYEG RFVLRFEDTD PRTKRPLPEA
160 170 180 190 200
YEAIKEDLSW LGIGWDEEYY QSQRMEVYYG LLRELVRRGG AYVCTCPPEE
210 220 230 240 250
WRKLRDEGKP CPHRDLPPEE QEELLDQVLE GKFGEGEAVV RVKTDLRHPD
260 270 280 290 300
PSVRDWVAFR IIDTSKHPHP LTGDKYVLWP TYNFAAGVDD YLMGITHVLR
310 320 330 340 350
AREHRQNTVK QEFLYKHLGW TMPTVIHFGR LKLEGFVLSK SKMREAGFKG
360 370 380 390 400
DDPRAATIRG LRRRGFAPEA IREVMLSVGI KSSDASISFA NLAAENKKVI
410 420 430 440 450
DKKAYRVMAV EDPAPAKLLA PEPLEAELPW HPTEGLGSRK YSVEPGEVVY
460 470 480 490 500
LERADLRRAK RRGGLRLMEL ANFKYKGFDE DEGVYLLEFE SKELDKEKGY
510 520 530 540 550
DIVQWVKDPK GAIVWRPGER KSFALVEPEA LKLEGWVQLI RKGYAKVDGV
560
EEDTLNLIYL HE
Length:562
Mass (Da):64,685
Last modified:October 23, 2007 - v1
Checksum:i1416697F0F34CB10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000816 Genomic DNA Translation: ABU82287.1
RefSeqiWP_012123251.1, NC_009776.1

Genome annotation databases

EnsemblBacteriaiABU82287; ABU82287; Igni_1110
GeneIDi5562106
KEGGiiho:Igni_1110

Similar proteinsi

Entry informationi

Entry nameiSYE_IGNH4
AccessioniPrimary (citable) accession number: A8ABI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health