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Protein

DNA ligase

Gene

lig

Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei256ATPUniRule annotation1
Active sitei258N6-AMP-lysine intermediateUniRule annotation1
Binding sitei263ATPUniRule annotation1
Binding sitei279ATPUniRule annotation1
Binding sitei309ATPUniRule annotation1
Binding sitei349ATPUniRule annotation1
Binding sitei426ATPUniRule annotation1
Binding sitei432ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Igni_0942
OrganismiIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Taxonomic identifieri453591 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus
Proteomesi
  • UP000000262 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000498671 – 594DNA ligaseAdd BLAST594

Interactioni

Protein-protein interaction databases

STRINGi453591.Igni_0942.

Structurei

3D structure databases

ProteinModelPortaliA8AB20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347. Archaea.
COG1793. LUCA.
HOGENOMiHOG000036008.
KOiK10747.
OMAiPQVVIEV.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8AB20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFSDVVDAL ERLERTTSRT QIVAILTNLF KKVIEENKDI IDKVVYFIQG
60 70 80 90 100
KLWPDWYGYP EIGIGEKGII KAISLAANVK EKEVEGLYKQ LGDLGLVAER
110 120 130 140 150
LMAKAPKGGL MMFVKKKEEL TFEKVYETLK RIAFMQGEGS RDLKIKTLAG
160 170 180 190 200
LLKEASPKEA KYIVRFVQGK LRLGVGDASI IEALAHVAGT TKDVVERAYN
210 220 230 240 250
LRADLGAVAK IAVTEGPEAL KRVRPKPGVP VRPMLAERLN DPKEILKKLG
260 270 280 290 300
GKGLAEYKYD GERAQIHLLP DGKVVIFSRR LENITRSYPD VVQYAKSGLK
310 320 330 340 350
AKEAIVEGEI IAVNPETGEP RPFQELMRRR RKHDVALAMS EIPVNVKLFD
360 370 380 390 400
IIYVDGEDMT NKPLPLRRKR LEEVVEESEE FSLSTAKLVS TPEELEQFFH
410 420 430 440 450
QSISEGHEGL VVKAVHDKSV YQAGARGWLW IKYKKDYKSE MVEPVDLVVV
460 470 480 490 500
GAFYGRGRRG GTFGALLVAG YDEKRDAFAT VCKVGSGFSD EELARLPELL
510 520 530 540 550
KPYISETKPP RVISNVKPDV WVRPALVAEI IGAEITLSPI HTCAKDEVSA
560 570 580 590
GSGLAIRFPR FIRWRPDKGP EDATTCGEIV EMYKSRLKKV EEPT
Length:594
Mass (Da):66,459
Last modified:October 23, 2007 - v1
Checksum:i2AB8030EEC27B803
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000816 Genomic DNA. Translation: ABU82122.1.
RefSeqiWP_012123086.1. NC_009776.1.

Genome annotation databases

EnsemblBacteriaiABU82122; ABU82122; Igni_0942.
GeneIDi5562329.
KEGGiiho:Igni_0942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000816 Genomic DNA. Translation: ABU82122.1.
RefSeqiWP_012123086.1. NC_009776.1.

3D structure databases

ProteinModelPortaliA8AB20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi453591.Igni_0942.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU82122; ABU82122; Igni_0942.
GeneIDi5562329.
KEGGiiho:Igni_0942.

Phylogenomic databases

eggNOGiarCOG01347. Archaea.
COG1793. LUCA.
HOGENOMiHOG000036008.
KOiK10747.
OMAiPQVVIEV.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNLI_IGNH4
AccessioniPrimary (citable) accession number: A8AB20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: November 30, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.