Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA ligase

Gene

lig

Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei256ATPUniRule annotation1
Active sitei258N6-AMP-lysine intermediateUniRule annotation1
Binding sitei263ATPUniRule annotation1
Binding sitei279ATPUniRule annotation1
Binding sitei309ATPUniRule annotation1
Binding sitei349ATPUniRule annotation1
Binding sitei426ATPUniRule annotation1
Binding sitei432ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciIHOS453591:G1G9W-974-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Igni_0942
OrganismiIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Taxonomic identifieri453591 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus
Proteomesi
  • UP000000262 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000498671 – 594DNA ligaseAdd BLAST594

Proteomic databases

PRIDEiA8AB20

Interactioni

Protein-protein interaction databases

STRINGi453591.Igni_0942

Structurei

3D structure databases

ProteinModelPortaliA8AB20
SMRiA8AB20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWIKYKRD
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

A8AB20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFSDVVDAL ERLERTTSRT QIVAILTNLF KKVIEENKDI IDKVVYFIQG
60 70 80 90 100
KLWPDWYGYP EIGIGEKGII KAISLAANVK EKEVEGLYKQ LGDLGLVAER
110 120 130 140 150
LMAKAPKGGL MMFVKKKEEL TFEKVYETLK RIAFMQGEGS RDLKIKTLAG
160 170 180 190 200
LLKEASPKEA KYIVRFVQGK LRLGVGDASI IEALAHVAGT TKDVVERAYN
210 220 230 240 250
LRADLGAVAK IAVTEGPEAL KRVRPKPGVP VRPMLAERLN DPKEILKKLG
260 270 280 290 300
GKGLAEYKYD GERAQIHLLP DGKVVIFSRR LENITRSYPD VVQYAKSGLK
310 320 330 340 350
AKEAIVEGEI IAVNPETGEP RPFQELMRRR RKHDVALAMS EIPVNVKLFD
360 370 380 390 400
IIYVDGEDMT NKPLPLRRKR LEEVVEESEE FSLSTAKLVS TPEELEQFFH
410 420 430 440 450
QSISEGHEGL VVKAVHDKSV YQAGARGWLW IKYKKDYKSE MVEPVDLVVV
460 470 480 490 500
GAFYGRGRRG GTFGALLVAG YDEKRDAFAT VCKVGSGFSD EELARLPELL
510 520 530 540 550
KPYISETKPP RVISNVKPDV WVRPALVAEI IGAEITLSPI HTCAKDEVSA
560 570 580 590
GSGLAIRFPR FIRWRPDKGP EDATTCGEIV EMYKSRLKKV EEPT
Length:594
Mass (Da):66,459
Last modified:October 23, 2007 - v1
Checksum:i2AB8030EEC27B803
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000816 Genomic DNA Translation: ABU82122.1
RefSeqiWP_012123086.1, NC_009776.1

Genome annotation databases

EnsemblBacteriaiABU82122; ABU82122; Igni_0942
GeneIDi5562329
KEGGiiho:Igni_0942

Similar proteinsi

Entry informationi

Entry nameiDNLI_IGNH4
AccessioniPrimary (citable) accession number: A8AB20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health