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A8AB20

- DNLI_IGNH4

UniProt

A8AB20 - DNLI_IGNH4

Protein

DNA ligase

Gene

lig

Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei256 – 2561ATPUniRule annotation
    Active sitei258 – 2581N6-AMP-lysine intermediateUniRule annotation
    Binding sitei263 – 2631ATPUniRule annotation
    Binding sitei279 – 2791ATPUniRule annotation
    Binding sitei309 – 3091ATPUniRule annotation
    Binding sitei349 – 3491ATPUniRule annotation
    Binding sitei426 – 4261ATPUniRule annotation
    Binding sitei432 – 4321ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciIHOS453591:GHYN-968-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Igni_0942
    OrganismiIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
    Taxonomic identifieri453591 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus
    ProteomesiUP000000262: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 594594DNA ligasePRO_1000049867Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi453591.Igni_0942.

    Structurei

    3D structure databases

    ProteinModelPortaliA8AB20.
    SMRiA8AB20. Positions 1-589.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiCTDIGEL.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8AB20-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFSDVVDAL ERLERTTSRT QIVAILTNLF KKVIEENKDI IDKVVYFIQG    50
    KLWPDWYGYP EIGIGEKGII KAISLAANVK EKEVEGLYKQ LGDLGLVAER 100
    LMAKAPKGGL MMFVKKKEEL TFEKVYETLK RIAFMQGEGS RDLKIKTLAG 150
    LLKEASPKEA KYIVRFVQGK LRLGVGDASI IEALAHVAGT TKDVVERAYN 200
    LRADLGAVAK IAVTEGPEAL KRVRPKPGVP VRPMLAERLN DPKEILKKLG 250
    GKGLAEYKYD GERAQIHLLP DGKVVIFSRR LENITRSYPD VVQYAKSGLK 300
    AKEAIVEGEI IAVNPETGEP RPFQELMRRR RKHDVALAMS EIPVNVKLFD 350
    IIYVDGEDMT NKPLPLRRKR LEEVVEESEE FSLSTAKLVS TPEELEQFFH 400
    QSISEGHEGL VVKAVHDKSV YQAGARGWLW IKYKKDYKSE MVEPVDLVVV 450
    GAFYGRGRRG GTFGALLVAG YDEKRDAFAT VCKVGSGFSD EELARLPELL 500
    KPYISETKPP RVISNVKPDV WVRPALVAEI IGAEITLSPI HTCAKDEVSA 550
    GSGLAIRFPR FIRWRPDKGP EDATTCGEIV EMYKSRLKKV EEPT 594
    Length:594
    Mass (Da):66,459
    Last modified:October 23, 2007 - v1
    Checksum:i2AB8030EEC27B803
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000816 Genomic DNA. Translation: ABU82122.1.
    RefSeqiYP_001435529.1. NC_009776.1.

    Genome annotation databases

    EnsemblBacteriaiABU82122; ABU82122; Igni_0942.
    GeneIDi5562329.
    KEGGiiho:Igni_0942.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000816 Genomic DNA. Translation: ABU82122.1 .
    RefSeqi YP_001435529.1. NC_009776.1.

    3D structure databases

    ProteinModelPortali A8AB20.
    SMRi A8AB20. Positions 1-589.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 453591.Igni_0942.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU82122 ; ABU82122 ; Igni_0942 .
    GeneIDi 5562329.
    KEGGi iho:Igni_0942.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi CTDIGEL.

    Enzyme and pathway databases

    BioCyci IHOS453591:GHYN-968-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIN4/I / DSM 18386 / JCM 14125.

    Entry informationi

    Entry nameiDNLI_IGNH4
    AccessioniPrimary (citable) accession number: A8AB20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3