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A8AB20 (DNLI_IGNH4) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:Igni_0942
OrganismIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) [Complete proteome] [HAMAP]
Taxonomic identifier453591 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus

Protein attributes

Sequence length594 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 594594DNA ligase HAMAP-Rule MF_00407
PRO_1000049867

Sites

Active site2581N6-AMP-lysine intermediate By similarity
Binding site2561ATP By similarity
Binding site2631ATP By similarity
Binding site2791ATP By similarity
Binding site3091ATP By similarity
Binding site3491ATP By similarity
Binding site4261ATP By similarity
Binding site4321ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A8AB20 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 2AB8030EEC27B803

FASTA59466,459
        10         20         30         40         50         60 
MKFSDVVDAL ERLERTTSRT QIVAILTNLF KKVIEENKDI IDKVVYFIQG KLWPDWYGYP 

        70         80         90        100        110        120 
EIGIGEKGII KAISLAANVK EKEVEGLYKQ LGDLGLVAER LMAKAPKGGL MMFVKKKEEL 

       130        140        150        160        170        180 
TFEKVYETLK RIAFMQGEGS RDLKIKTLAG LLKEASPKEA KYIVRFVQGK LRLGVGDASI 

       190        200        210        220        230        240 
IEALAHVAGT TKDVVERAYN LRADLGAVAK IAVTEGPEAL KRVRPKPGVP VRPMLAERLN 

       250        260        270        280        290        300 
DPKEILKKLG GKGLAEYKYD GERAQIHLLP DGKVVIFSRR LENITRSYPD VVQYAKSGLK 

       310        320        330        340        350        360 
AKEAIVEGEI IAVNPETGEP RPFQELMRRR RKHDVALAMS EIPVNVKLFD IIYVDGEDMT 

       370        380        390        400        410        420 
NKPLPLRRKR LEEVVEESEE FSLSTAKLVS TPEELEQFFH QSISEGHEGL VVKAVHDKSV 

       430        440        450        460        470        480 
YQAGARGWLW IKYKKDYKSE MVEPVDLVVV GAFYGRGRRG GTFGALLVAG YDEKRDAFAT 

       490        500        510        520        530        540 
VCKVGSGFSD EELARLPELL KPYISETKPP RVISNVKPDV WVRPALVAEI IGAEITLSPI 

       550        560        570        580        590 
HTCAKDEVSA GSGLAIRFPR FIRWRPDKGP EDATTCGEIV EMYKSRLKKV EEPT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000816 Genomic DNA. Translation: ABU82122.1.
RefSeqYP_001435529.1. NC_009776.1.

3D structure databases

ProteinModelPortalA8AB20.
SMRA8AB20. Positions 1-589.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING453591.Igni_0942.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABU82122; ABU82122; Igni_0942.
GeneID5562329.
KEGGiho:Igni_0942.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK10747.
OMAYIARFVV.
ProtClustDBPRK01109.

Enzyme and pathway databases

BioCycIHOS453591:GHYN-968-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_IGNH4
AccessionPrimary (citable) accession number: A8AB20
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families