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A8AB14 (A8AB14_IGNH4) Unreviewed, UniProtKB/TrEMBL

Last modified November 16, 2011. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6,7-dimethyl-8-ribityllumazine synthase HAMAP MF_00178
Short name=DMRL synthase HAMAP MF_00178
Short name=Lumazine synthase HAMAP MF_00178
EC=2.5.1.9 HAMAP MF_00178
Alternative name(s):
Riboflavin synthase beta chain HAMAP MF_00178
Gene names
Name:ribH HAMAP MF_00178
Ordered Locus Names:Igni_0936
OrganismIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) [Complete proteome] [HAMAP]
Taxonomic identifier453591 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Ignicoccus

Protein attributes

Sequence length139 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2-butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes the condensation of 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate yielding 6,7-dimethyl-8-lumazine By similarity. HAMAP MF_00178

Catalytic activity

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. HAMAP MF_00178 RuleBase RU003795

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2. HAMAP MF_00178 RuleBase RU003795

Sequence similarities

Belongs to the DMRL synthase family. HAMAP MF_00178 RuleBase RU003795

Sequences

Sequence LengthMass (Da)Tools
A8AB14 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 8277AFA89F470C99

FASTA13915,176
        10         20         30         40         50         60 
MRLGIVVSEF NYDITRLMLE KALDHAKFLG VEEVLVLKVP GSFEAPLAAK RLLEEGCDAV 

        70         80         90        100        110        120 
AVLGAVIKGE TDHDQVVAHQ VARKLMDLSL EYGKPVTLGV IGPGATREQA AERIEEYARR 

       130 
AVEAAVKAWK RLNEGPQLA

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000816 Genomic DNA. Translation: ABU82116.1.
RefSeqYP_001435523.1. NC_009776.1.

3D structure databases

ProteinModelPortalA8AB14.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8AB14.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5562376.
GenomeReviewsGene locus Igni_0936 in contig CP000816_GR.
KEGGiho:Igni_0936.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG09975.
HOGENOMHBG311126.
OMAIQGATKH.

Family and domain databases

HAMAPMF_00178. Lumazine_synth.
[Tree]
InterProIPR002180. DMRL_synthase.
[Graphical view]
Gene3DG3DSA:3.40.50.960. DMRL_synthase. 1 hit.
KOK00794.
PANTHERPTHR21058. DMRL_synthase. 1 hit.
PfamPF00885. DMRL_synthase. 1 hit.
[Graphical view]
SUPFAMSSF52121. DMRL_synthase. 1 hit.
TIGRFAMsTIGR00114. Lumazine-synth. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA8AB14_IGNH4
AccessionPrimary (citable) accession number: A8AB14
Entry history
Integrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 16, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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