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Protein

Protein-L-isoaspartate O-methyltransferase

Gene

pcm

Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei59 – 591UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciIHOS453591:GHYN-903-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferaseUniRule annotation (EC:2.1.1.77UniRule annotation)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferaseUniRule annotation
Protein L-isoaspartyl methyltransferaseUniRule annotation
Protein-beta-aspartate methyltransferaseUniRule annotation
Short name:
PIMTUniRule annotation
Gene namesi
Name:pcmUniRule annotation
Ordered Locus Names:Igni_0877
OrganismiIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Taxonomic identifieri453591 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus
Proteomesi
  • UP000000262 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Protein-L-isoaspartate O-methyltransferasePRO_0000351966Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi453591.Igni_0877.

Structurei

3D structure databases

ProteinModelPortaliA8AAV7.
SMRiA8AAV7. Positions 2-211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00976. Archaea.
COG2518. LUCA.
HOGENOMiHOG000257189.
KOiK00573.
OMAiFAIERHA.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8AAV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKKRELIR NLIAEGYIKR KEVAEAMMKV PRELFVPEEL RHMAYEDTPL
60 70 80 90 100
PIGAGQTISA PHMVAYMVEA AELRRGDKVL EVGTGSGYHA AVMAELVGPE
110 120 130 140 150
GHVYTIERIP ELAERARERL KALGYNNVTV LVGDGSKGYP PAAPYDKIIV
160 170 180 190 200
TAAAKRVPEA LLKQLKVGGI MVIPVEEEPG YQVLYKIIKT PEGYVIKKLL
210
PVAFVPLIEE E
Length:211
Mass (Da):23,388
Last modified:October 23, 2007 - v1
Checksum:i92B0B97655D1EFDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000816 Genomic DNA. Translation: ABU82059.1.
RefSeqiWP_012123023.1. NC_009776.1.

Genome annotation databases

EnsemblBacteriaiABU82059; ABU82059; Igni_0877.
GeneIDi5562192.
KEGGiiho:Igni_0877.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000816 Genomic DNA. Translation: ABU82059.1.
RefSeqiWP_012123023.1. NC_009776.1.

3D structure databases

ProteinModelPortaliA8AAV7.
SMRiA8AAV7. Positions 2-211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi453591.Igni_0877.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU82059; ABU82059; Igni_0877.
GeneIDi5562192.
KEGGiiho:Igni_0877.

Phylogenomic databases

eggNOGiarCOG00976. Archaea.
COG2518. LUCA.
HOGENOMiHOG000257189.
KOiK00573.
OMAiFAIERHA.

Enzyme and pathway databases

BioCyciIHOS453591:GHYN-903-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIN4/I / DSM 18386 / JCM 14125.

Entry informationi

Entry nameiPIMT_IGNH4
AccessioniPrimary (citable) accession number: A8AAV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: October 23, 2007
Last modified: May 11, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.