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A8AA65

- ASSY_IGNH4

UniProt

A8AA65 - ASSY_IGNH4

Protein

Argininosuccinate synthase

Gene

argG

Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei85 – 851CitrullineUniRule annotation
    Binding sitei115 – 1151ATP; via amide nitrogenUniRule annotation
    Binding sitei117 – 1171AspartateUniRule annotation
    Binding sitei121 – 1211AspartateUniRule annotation
    Binding sitei121 – 1211CitrullineUniRule annotation
    Binding sitei122 – 1221AspartateUniRule annotation
    Binding sitei125 – 1251CitrullineUniRule annotation
    Binding sitei172 – 1721CitrullineUniRule annotation
    Binding sitei181 – 1811CitrullineUniRule annotation
    Binding sitei257 – 2571CitrullineUniRule annotation
    Binding sitei269 – 2691CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 159ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciIHOS453591:GHYN-657-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:Igni_0635
    OrganismiIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
    Taxonomic identifieri453591 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus
    ProteomesiUP000000262: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396Argininosuccinate synthasePRO_0000321321Add
    BLAST

    Proteomic databases

    PRIDEiA8AA65.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi453591.Igni_0635.

    Structurei

    3D structure databases

    ProteinModelPortaliA8AA65.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiRFESTIR.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8AA65-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKIVLAYSG GLDTSVAVAW LKEKFGAEVI TVTVDVGQKE DFKEIEERAY    50
    KAGASKHYLI DAKEEFVNKY IKPAIIANAL YEEVYPLGTA LARPLIGEKV 100
    IEVARKEGAD AVAHGATSKG NDQVRFEAAF KALAPEIKII APIRMWGMNR 150
    KEEYEFAKKK GIPISAESKK YSIDENLWSR SIEGGELEDP WQEPPEEAFE 200
    WTVPPEKAPE EPAYLTITFE KGVPVALNGK RMELIEIIDT LNKLAGQHGY 250
    GRVDHMENRV VGLKSREVYE APAALTIINS KKDLEKLVLN KREYRIKRML 300
    DSYWADLVYD GLWFDPIRVA LDNMLSELSE NVNGDVKVKL YKGSLRVVGR 350
    RSPNAIYDKA ISSYESEWFP SDEMARGFID AWLMDSVVSF RKRYLK 396
    Length:396
    Mass (Da):44,838
    Last modified:October 23, 2007 - v1
    Checksum:i621D9D80F1D9D3DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000816 Genomic DNA. Translation: ABU81817.1.
    RefSeqiWP_011998669.1. NC_009776.1.
    YP_001435224.1. NC_009776.1.

    Genome annotation databases

    EnsemblBacteriaiABU81817; ABU81817; Igni_0635.
    GeneIDi5563088.
    KEGGiiho:Igni_0635.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000816 Genomic DNA. Translation: ABU81817.1 .
    RefSeqi WP_011998669.1. NC_009776.1.
    YP_001435224.1. NC_009776.1.

    3D structure databases

    ProteinModelPortali A8AA65.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 453591.Igni_0635.

    Proteomic databases

    PRIDEi A8AA65.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU81817 ; ABU81817 ; Igni_0635 .
    GeneIDi 5563088.
    KEGGi iho:Igni_0635.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi RFESTIR.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci IHOS453591:GHYN-657-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIN4/I / DSM 18386 / JCM 14125.

    Entry informationi

    Entry nameiASSY_IGNH4
    AccessioniPrimary (citable) accession number: A8AA65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3