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A8AA51

- ARGB_IGNH4

UniProt

A8AA51 - ARGB_IGNH4

Protein

Acetylglutamate/acetylaminoadipate kinase

Gene

argB

Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Involved in both the arginine and lysine biosynthetic pathways.UniRule annotation

    Catalytic activityi

    ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.UniRule annotation
    ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei5 – 51Transition state stabilizerUniRule annotation
    Binding sitei61 – 611SubstrateUniRule annotation
    Binding sitei169 – 1691SubstrateUniRule annotation
    Sitei226 – 2261Transition state stabilizerUniRule annotation

    GO - Molecular functioni

    1. acetylglutamate kinase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP
    2. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis, Lysine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciIHOS453591:GHYN-642-MONOMER.
    UniPathwayiUPA00033; UER00036.
    UPA00068; UER00107.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetylglutamate/acetylaminoadipate kinaseUniRule annotation (EC:2.7.2.-UniRule annotation, EC:2.7.2.8UniRule annotation)
    Alternative name(s):
    N-acetyl-L-glutamate/N-acetyl-L-aminoadipate 5-phosphotransferaseUniRule annotation
    NAG kinaseUniRule annotation
    Short name:
    AGKUniRule annotation
    Gene namesi
    Name:argBUniRule annotation
    Synonyms:lysZUniRule annotation
    Ordered Locus Names:Igni_0621
    OrganismiIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
    Taxonomic identifieri453591 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus
    ProteomesiUP000000262: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 264264Acetylglutamate/acetylaminoadipate kinasePRO_1000010501Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi453591.Igni_0621.

    Structurei

    3D structure databases

    ProteinModelPortaliA8AA51.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni34 – 352Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the acetylglutamate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0548.
    HOGENOMiHOG000233259.
    KOiK05828.
    OMAiFMTKKVM.

    Family and domain databases

    Gene3Di3.40.1160.10. 1 hit.
    HAMAPiMF_00082_A. ArgB_A.
    InterProiIPR004662. AcgluKinase.
    IPR001048. Asp/Glu/Uridylate_kinase.
    [Graphical view]
    PfamiPF00696. AA_kinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000728. NAGK. 1 hit.
    SUPFAMiSSF53633. SSF53633. 1 hit.
    TIGRFAMsiTIGR00761. argB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8AA51-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIVVKAGGRT LLNNMDEIVK SISRLEKAVF VHGGGDLVDE WERKMGMEPQ    50
    FKVSASGIKF RYTDEKELEV FVAVLGGLLN KKIVASFASY GRGAVGLTGA 100
    DGPSVIAERK KKVIVQEKVG ERLVKRAIAG GYTGKIKEVK TDLIKALVER 150
    GLVPVVAPIA LSPEGELLNV NGDQMAAELA KALSAEYLVL LTDVPGVLMD 200
    GKVVPEIKSS EAEEVAKKVG PGMNIKIIMA GRVASGGTKV VICDGTVPDP 250
    LKCLEERSGT WVVP 264
    Length:264
    Mass (Da):28,079
    Last modified:October 23, 2007 - v1
    Checksum:i22480602AEBA6B23
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000816 Genomic DNA. Translation: ABU81803.1.
    RefSeqiYP_001435210.1. NC_009776.1.

    Genome annotation databases

    EnsemblBacteriaiABU81803; ABU81803; Igni_0621.
    GeneIDi5563045.
    KEGGiiho:Igni_0621.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000816 Genomic DNA. Translation: ABU81803.1 .
    RefSeqi YP_001435210.1. NC_009776.1.

    3D structure databases

    ProteinModelPortali A8AA51.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 453591.Igni_0621.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU81803 ; ABU81803 ; Igni_0621 .
    GeneIDi 5563045.
    KEGGi iho:Igni_0621.

    Phylogenomic databases

    eggNOGi COG0548.
    HOGENOMi HOG000233259.
    KOi K05828.
    OMAi FMTKKVM.

    Enzyme and pathway databases

    UniPathwayi UPA00033 ; UER00036 .
    UPA00068 ; UER00107 .
    BioCyci IHOS453591:GHYN-642-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1160.10. 1 hit.
    HAMAPi MF_00082_A. ArgB_A.
    InterProi IPR004662. AcgluKinase.
    IPR001048. Asp/Glu/Uridylate_kinase.
    [Graphical view ]
    Pfami PF00696. AA_kinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000728. NAGK. 1 hit.
    SUPFAMi SSF53633. SSF53633. 1 hit.
    TIGRFAMsi TIGR00761. argB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIN4/I / DSM 18386 / JCM 14125.

    Entry informationi

    Entry nameiARGB_IGNH4
    AccessioniPrimary (citable) accession number: A8AA51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3