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A8AA51 (ARGB_IGNH4) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetylglutamate/acetylaminoadipate kinase

EC=2.7.2.-
EC=2.7.2.8
Alternative name(s):
N-acetyl-L-glutamate/N-acetyl-L-aminoadipate 5-phosphotransferase
NAG kinase
Short name=AGK
Gene names
Name:argB
Synonyms:lysZ
Ordered Locus Names:Igni_0621
OrganismIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) [Complete proteome] [HAMAP]
Taxonomic identifier453591 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in both the arginine and lysine biosynthetic pathways By similarity. HAMAP-Rule MF_00082

Catalytic activity

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP-Rule MF_00082

ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate. HAMAP-Rule MF_00082

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP-Rule MF_00082

Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5. HAMAP-Rule MF_00082

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00082.

Sequence similarities

Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

lysine biosynthetic process via aminoadipic acid

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetylglutamate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 264264Acetylglutamate/acetylaminoadipate kinase HAMAP-Rule MF_00082
PRO_1000010501

Regions

Region34 – 352Substrate binding By similarity

Sites

Binding site611Substrate By similarity
Binding site1691Substrate By similarity
Site51Transition state stabilizer By similarity
Site2261Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
A8AA51 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 22480602AEBA6B23

FASTA26428,079
        10         20         30         40         50         60 
MIVVKAGGRT LLNNMDEIVK SISRLEKAVF VHGGGDLVDE WERKMGMEPQ FKVSASGIKF 

        70         80         90        100        110        120 
RYTDEKELEV FVAVLGGLLN KKIVASFASY GRGAVGLTGA DGPSVIAERK KKVIVQEKVG 

       130        140        150        160        170        180 
ERLVKRAIAG GYTGKIKEVK TDLIKALVER GLVPVVAPIA LSPEGELLNV NGDQMAAELA 

       190        200        210        220        230        240 
KALSAEYLVL LTDVPGVLMD GKVVPEIKSS EAEEVAKKVG PGMNIKIIMA GRVASGGTKV 

       250        260 
VICDGTVPDP LKCLEERSGT WVVP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000816 Genomic DNA. Translation: ABU81803.1.
RefSeqYP_001435210.1. NC_009776.1.

3D structure databases

ProteinModelPortalA8AA51.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING453591.Igni_0621.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABU81803; ABU81803; Igni_0621.
GeneID5563045.
KEGGiho:Igni_0621.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0548.
HOGENOMHOG000233259.
KOK05828.
OMAFMTKKVM.

Enzyme and pathway databases

BioCycIHOS453591:GHYN-642-MONOMER.
UniPathwayUPA00033; UER00036.
UPA00068; UER00107.

Family and domain databases

Gene3D3.40.1160.10. 1 hit.
HAMAPMF_00082_A. ArgB_A.
InterProIPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
[Graphical view]
PfamPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFPIRSF000728. NAGK. 1 hit.
SUPFAMSSF53633. SSF53633. 1 hit.
TIGRFAMsTIGR00761. argB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameARGB_IGNH4
AccessionPrimary (citable) accession number: A8AA51
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways