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A8AA51

- ARGB_IGNH4

UniProt

A8AA51 - ARGB_IGNH4

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Protein
Acetylglutamate/acetylaminoadipate kinase
Gene
argB, lysZ, Igni_0621
Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Involved in both the arginine and lysine biosynthetic pathways By similarity.UniRule annotation

Catalytic activityi

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.UniRule annotation
ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei5 – 51Transition state stabilizer By similarity
Binding sitei61 – 611Substrate By similarity
Binding sitei169 – 1691Substrate By similarity
Sitei226 – 2261Transition state stabilizer By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. acetylglutamate kinase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
  2. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis, Lysine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciIHOS453591:GHYN-642-MONOMER.
UniPathwayiUPA00033; UER00036.
UPA00068; UER00107.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylglutamate/acetylaminoadipate kinase (EC:2.7.2.-, EC:2.7.2.8)
Alternative name(s):
N-acetyl-L-glutamate/N-acetyl-L-aminoadipate 5-phosphotransferase
NAG kinase
Short name:
AGK
Gene namesi
Name:argB
Synonyms:lysZ
Ordered Locus Names:Igni_0621
OrganismiIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Taxonomic identifieri453591 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus
ProteomesiUP000000262: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Acetylglutamate/acetylaminoadipate kinaseUniRule annotation
PRO_1000010501Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi453591.Igni_0621.

Structurei

3D structure databases

ProteinModelPortaliA8AA51.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni34 – 352Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0548.
HOGENOMiHOG000233259.
KOiK05828.
OMAiFMTKKVM.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_00082_A. ArgB_A.
InterProiIPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000728. NAGK. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00761. argB. 1 hit.

Sequencei

Sequence statusi: Complete.

A8AA51-1 [UniParc]FASTAAdd to Basket

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MIVVKAGGRT LLNNMDEIVK SISRLEKAVF VHGGGDLVDE WERKMGMEPQ    50
FKVSASGIKF RYTDEKELEV FVAVLGGLLN KKIVASFASY GRGAVGLTGA 100
DGPSVIAERK KKVIVQEKVG ERLVKRAIAG GYTGKIKEVK TDLIKALVER 150
GLVPVVAPIA LSPEGELLNV NGDQMAAELA KALSAEYLVL LTDVPGVLMD 200
GKVVPEIKSS EAEEVAKKVG PGMNIKIIMA GRVASGGTKV VICDGTVPDP 250
LKCLEERSGT WVVP 264
Length:264
Mass (Da):28,079
Last modified:October 23, 2007 - v1
Checksum:i22480602AEBA6B23
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000816 Genomic DNA. Translation: ABU81803.1.
RefSeqiYP_001435210.1. NC_009776.1.

Genome annotation databases

EnsemblBacteriaiABU81803; ABU81803; Igni_0621.
GeneIDi5563045.
KEGGiiho:Igni_0621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000816 Genomic DNA. Translation: ABU81803.1 .
RefSeqi YP_001435210.1. NC_009776.1.

3D structure databases

ProteinModelPortali A8AA51.
ModBasei Search...

Protein-protein interaction databases

STRINGi 453591.Igni_0621.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU81803 ; ABU81803 ; Igni_0621 .
GeneIDi 5563045.
KEGGi iho:Igni_0621.

Phylogenomic databases

eggNOGi COG0548.
HOGENOMi HOG000233259.
KOi K05828.
OMAi FMTKKVM.

Enzyme and pathway databases

UniPathwayi UPA00033 ; UER00036 .
UPA00068 ; UER00107 .
BioCyci IHOS453591:GHYN-642-MONOMER.

Family and domain databases

Gene3Di 3.40.1160.10. 1 hit.
HAMAPi MF_00082_A. ArgB_A.
InterProi IPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000728. NAGK. 1 hit.
SUPFAMi SSF53633. SSF53633. 1 hit.
TIGRFAMsi TIGR00761. argB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIN4/I / DSM 18386 / JCM 14125.

Entry informationi

Entry nameiARGB_IGNH4
AccessioniPrimary (citable) accession number: A8AA51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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