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Protein

Acetylglutamate/acetylaminoadipate kinase

Gene

argB

Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in both the arginine and lysine biosynthetic pathways.UniRule annotation

Catalytic activityi

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.UniRule annotation
ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate.UniRule annotation

Pathway:iL-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Acetylglutamate/acetylaminoadipate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase (argC)
  4. no protein annotated in this organism
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Pathway:iL-lysine biosynthesis via AAA pathway

This protein is involved in step 2 of the subpathway that synthesizes L-lysine from L-alpha-aminoadipate (Thermus route).UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Acetylglutamate/acetylaminoadipate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase (argC)
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway L-lysine biosynthesis via AAA pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lysine from L-alpha-aminoadipate (Thermus route), the pathway L-lysine biosynthesis via AAA pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei5 – 51Transition state stabilizerUniRule annotation
Binding sitei61 – 611SubstrateUniRule annotation
Binding sitei169 – 1691SubstrateUniRule annotation
Sitei226 – 2261Transition state stabilizerUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis, Lysine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciIHOS453591:GHYN-642-MONOMER.
UniPathwayiUPA00033; UER00036.
UPA00068; UER00107.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylglutamate/acetylaminoadipate kinaseUniRule annotation (EC:2.7.2.-UniRule annotation, EC:2.7.2.8UniRule annotation)
Alternative name(s):
N-acetyl-L-glutamate/N-acetyl-L-aminoadipate 5-phosphotransferaseUniRule annotation
NAG kinaseUniRule annotation
Short name:
AGKUniRule annotation
Gene namesi
Name:argBUniRule annotation
Synonyms:lysZUniRule annotation
Ordered Locus Names:Igni_0621
OrganismiIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Taxonomic identifieri453591 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus
ProteomesiUP000000262 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Acetylglutamate/acetylaminoadipate kinasePRO_1000010501Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi453591.Igni_0621.

Structurei

3D structure databases

ProteinModelPortaliA8AA51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni34 – 352Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the acetylglutamate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0548.
HOGENOMiHOG000233259.
KOiK05828.
OMAiAEGFMTK.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_00082_A. ArgB_A.
InterProiIPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000728. NAGK. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00761. argB. 1 hit.

Sequencei

Sequence statusi: Complete.

A8AA51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVVKAGGRT LLNNMDEIVK SISRLEKAVF VHGGGDLVDE WERKMGMEPQ
60 70 80 90 100
FKVSASGIKF RYTDEKELEV FVAVLGGLLN KKIVASFASY GRGAVGLTGA
110 120 130 140 150
DGPSVIAERK KKVIVQEKVG ERLVKRAIAG GYTGKIKEVK TDLIKALVER
160 170 180 190 200
GLVPVVAPIA LSPEGELLNV NGDQMAAELA KALSAEYLVL LTDVPGVLMD
210 220 230 240 250
GKVVPEIKSS EAEEVAKKVG PGMNIKIIMA GRVASGGTKV VICDGTVPDP
260
LKCLEERSGT WVVP
Length:264
Mass (Da):28,079
Last modified:October 23, 2007 - v1
Checksum:i22480602AEBA6B23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000816 Genomic DNA. Translation: ABU81803.1.
RefSeqiWP_011998655.1. NC_009776.1.
YP_001435210.1. NC_009776.1.

Genome annotation databases

EnsemblBacteriaiABU81803; ABU81803; Igni_0621.
GeneIDi5563045.
KEGGiiho:Igni_0621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000816 Genomic DNA. Translation: ABU81803.1.
RefSeqiWP_011998655.1. NC_009776.1.
YP_001435210.1. NC_009776.1.

3D structure databases

ProteinModelPortaliA8AA51.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi453591.Igni_0621.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU81803; ABU81803; Igni_0621.
GeneIDi5563045.
KEGGiiho:Igni_0621.

Phylogenomic databases

eggNOGiCOG0548.
HOGENOMiHOG000233259.
KOiK05828.
OMAiAEGFMTK.

Enzyme and pathway databases

UniPathwayiUPA00033; UER00036.
UPA00068; UER00107.
BioCyciIHOS453591:GHYN-642-MONOMER.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_00082_A. ArgB_A.
InterProiIPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000728. NAGK. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00761. argB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIN4/I / DSM 18386 / JCM 14125.

Entry informationi

Entry nameiARGB_IGNH4
AccessioniPrimary (citable) accession number: A8AA51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: July 22, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.