A8AA51 (ARGB_IGNH4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate/acetylaminoadipate kinase
EC=2.7.2.-
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate/N-acetyl-L-aminoadipate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Synonyms:	lysZ
Ordered Locus Names:	Igni_0621

Organism

Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) [Complete proteome] [HAMAP]

Taxonomic identifier

453591 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Ignicoccus › Ignicoccus hospitalis

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in both the arginine and lysine biosynthetic pathways By similarity. HAMAP-Rule MF_00082
Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP-Rule MF_00082 ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate. HAMAP-Rule MF_00082
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP-Rule MF_00082 Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5. HAMAP-Rule MF_00082
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00082.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP lysine biosynthetic process via aminoadipic acid Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP acetylglutamate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Acetylglutamate/acetylaminoadipate kinase HAMAP-Rule MF_00082		PRO_1000010501
Regions
	Region	34 – 35	2	Substrate binding By similarity
Sites
	Binding site	61	1	Substrate By similarity
	Binding site	169	1	Substrate By similarity
	Site	5	1	Transition state stabilizer By similarity
	Site	226	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8AA51 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 22480602AEBA6B23	FASTA	264	28,079
	10 20 30 40 50 60 MIVVKAGGRT LLNNMDEIVK SISRLEKAVF VHGGGDLVDE WERKMGMEPQ FKVSASGIKF 70 80 90 100 110 120 RYTDEKELEV FVAVLGGLLN KKIVASFASY GRGAVGLTGA DGPSVIAERK KKVIVQEKVG 130 140 150 160 170 180 ERLVKRAIAG GYTGKIKEVK TDLIKALVER GLVPVVAPIA LSPEGELLNV NGDQMAAELA 190 200 210 220 230 240 KALSAEYLVL LTDVPGVLMD GKVVPEIKSS EAEEVAKKVG PGMNIKIIMA GRVASGGTKV 250 260 VICDGTVPDP LKCLEERSGT WVVP

References

[1]

"A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitans." Podar M., Anderson I., Makarova K.S., Elkins J.G., Ivanova N., Wall M.A., Lykidis A., Mavromatis K., Sun H., Hudson M.E., Chen W., Deciu C., Hutchison D., Eads J.R., Anderson A., Fernandes F., Szeto E., Lapidus A. , Kyrpides N.C., Saier M.H. Jr., Richardson P.M., Rachel R., Huber H., Eisen J.A., Koonin E.V., Keller M., Stetter K.O. Genome Biol. 9:R158.1-R158.18(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIN4/I / DSM 18386 / JCM 14125.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000816 Genomic DNA. Translation: ABU81803.1.
RefSeq	YP_001435210.1. NC_009776.1.
3D structure databases
ProteinModelPortal	A8AA51.
ModBase	Search...
Protein-protein interaction databases
STRING	453591.Igni_0621.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABU81803; ABU81803; Igni_0621.
GeneID	5563045.
KEGG	iho:Igni_0621.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HOG000233259.
KO	K05828.
OMA	VGRFTDE.
Enzyme and pathway databases
BioCyc	IHOS453591:GHYN-642-MONOMER.
UniPathway	UPA00033; UER00036. UPA00068; UER00107.
Family and domain databases
Gene3D	3.40.1160.10. 1 hit.
HAMAP	MF_00082_A. ArgB_A.
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. argB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_IGNH4

Accession

Primary (citable) accession number: A8AA51

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 23, 2007
Last modified:	May 29, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program