A8AA47 (FENR_IGNH4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferredoxin--NADP reductase
Short name=FNR
Short name=Fd-NADP+ reductase
EC=1.18.1.2

Gene names

Ordered Locus Names:

Igni_0617

Organism

Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) [Complete proteome] [HAMAP]

Taxonomic identifier

453591 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Ignicoccus

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH. HAMAP MF_01685
Cofactor	Binds 1 FAD per subunit By similarity. HAMAP MF_01685
Subunit structure	Homodimer By similarity. HAMAP MF_01685
Sequence similarities	Belongs to the ferredoxin--NADP reductase type 2 family.

Ontologies

Keywords
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ferredoxin-NADP+ reductase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Ferredoxin--NADP reductase HAMAP MF_01685		PRO_0000364986
Sites
	Binding site	31	1	FAD By similarity
	Binding site	42	1	FAD By similarity
	Binding site	82	1	FAD; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	274	1	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8AA47 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: B5E9108791C0C32F	FASTA	305	33,024
	10 20 30 40 50 60 MRDALVVGAG PAGLTAAATL KQYGVEPLVI EAERVMATVY SYAWKPVENY PGFDGKRAIE 70 80 90 100 110 120 IARAFEEMQK FFGVEVVEKE RVVKAWKEGD KIVLGTQSGN EYEGKVLIIA IGILGKPRRL 130 140 150 160 170 180 GIPNEDAPNV HYIVKDPTAF AGSKVVVVGG GDTAVDTATV LAESGAQVTI VHRRDQFRAP 190 200 210 220 230 240 MRSIERMVRA GVKMVLNSVP KEIIAKDGKA TALVVTHKEG GETVLPLDHL VISIGFEPPD 250 260 270 280 290 300 LEWVKSLGVN MRGKEILVDD KMRTNVKGVF AAGDITPAPK RILVAAAQGY IAGFTAFRYI RTGVW

References

[1]

"A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitans." Podar M., Anderson I., Makarova K.S., Elkins J.G., Ivanova N., Wall M.A., Lykidis A., Mavromatis K., Sun H., Hudson M.E., Chen W., Deciu C., Hutchison D., Eads J.R., Anderson A., Fernandes F., Szeto E., Lapidus A. , Kyrpides N.C., Saier M.H. Jr., Richardson P.M., Rachel R., Huber H., Eisen J.A., Koonin E.V., Keller M., Stetter K.O. Genome Biol. 9:R158.1-R158.18(2008) [PubMed: 19000309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIN4/I / DSM 18386 / JCM 14125.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000816 Genomic DNA. Translation: ABU81799.1.
RefSeq	YP_001435206.1. NC_009776.1.
3D structure databases
ProteinModelPortal	A8AA47.
ModBase	Search...
Protein-protein interaction databases
STRING	A8AA47.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5562794.
GenomeReviews	Gene locus Igni_0617 in contig CP000816_GR.
KEGG	iho:Igni_0617.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG07126.
HOGENOM	HBG669726.
Enzyme and pathway databases
BioCyc	IHOS453591:IGNI_0617-MONOMER.
Family and domain databases
HAMAP	MF_01685. FENR2. [Tree]
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR022890. Fd--NADP_Rdtase_type_2. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR000103. Pyridine_nuc-diS_OxRdtase_2. [Graphical view]
KO	K00384.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
ProtoNet	Search...

Entry information

Entry name

FENR_IGNH4

Accession

Primary (citable) accession number: A8AA47

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	October 23, 2007
Last modified:	November 16, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program