A8AA38 (A8AA38_IGNH4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Ketol-acid reductoisomerase HAMAP MF_00435
EC=1.1.1.86 HAMAP MF_00435

Alternative name(s):
Acetohydroxy-acid isomeroreductase HAMAP MF_00435
Alpha-keto-beta-hydroxylacil reductoisomerase HAMAP MF_00435

Gene names

Name:	ilvC HAMAP MF_00435
Ordered Locus Names:	Igni_0608

Organism

Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) [Complete proteome] [HAMAP]

Taxonomic identifier

453591 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Ignicoccus

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435 (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435
Sequence similarities	Belongs to the ketol-acid reductoisomerase family. HAMAP MF_00435

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis HAMAP MF_00435
Ligand	NADP HAMAP MF_00435
Molecular function	Isomerase EMBL ABU81790.1 Oxidoreductase HAMAP MF_00435 EMBL ABU81790.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoleucine biosynthetic process Inferred from electronic annotation. Source: HAMAP valine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	122	1	By similarity HAMAP MF_00435

Sequences

	Sequence		Length	Mass (Da)
	A8AA38 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: FFCACC0F422717C6	FASTA	343	37,773
	10 20 30 40 50 60 MGLNAGALRR VGVTVAQIWK DSDVSLEPLK GRKVAIIGYG SQGRAWALNI RDSGVDVVVG 70 80 90 100 110 120 LRPGGKSWEL ATKDGFEPKP IPEAAKEGDV IAMLIPDMAQ PEIYEKYVEP NLHEGNALVF 130 140 150 160 170 180 AHGFNIHYGL IKPPKNVDVI MVAPKSPGPK VREAFLSGRG VPALVAVHQD YTGKAWDLVL 190 200 210 220 230 240 ALAKALGCTR AGVIKTTFKE ETESDLIGEQ TVLVGGLMEL LKKGFENLVE LGYQPEVAYF 250 260 270 280 290 300 EAINEAKLIM DLIWQYGFYG MLLRVSDTAK YGGLTVGPKV IDEHVKENMK KASERVISGE 310 320 330 340 FAKEWVEEYK KGMPTLKELM EKVKEHQAEK VGKELRKLMG LEE

References

[1]

"A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitans." Podar M., Anderson I., Makarova K.S., Elkins J.G., Ivanova N., Wall M.A., Lykidis A., Mavromatis K., Sun H., Hudson M.E., Chen W., Deciu C., Hutchison D., Eads J.R., Anderson A., Fernandes F., Szeto E., Lapidus A. , Kyrpides N.C., Saier M.H. Jr., Richardson P.M., Rachel R., Huber H., Eisen J.A., Koonin E.V., Keller M., Stetter K.O. Genome Biol. 9:R158.1-R158.18(2008) [PubMed: 19000309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000816 Genomic DNA. Translation: ABU81790.1.
RefSeq	YP_001435197.1. NC_009776.1.
3D structure databases
ProteinModelPortal	A8AA38.
ModBase	Search...
Protein-protein interaction databases
STRING	A8AA38.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5562650.
GenomeReviews	Gene locus Igni_0608 in contig CP000816_GR.
KEGG	iho:Igni_0608.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04335.
HOGENOM	HBG286525.
OMA	MAYAKGI.
Family and domain databases
HAMAP	MF_00435. IlvC. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013328. DH_multihelical. IPR013116. IlvN. [Graphical view]
Gene3D	G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00053.
PANTHER	PTHR21371. AcH_isomrdctse. 1 hit.
Pfam	PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00465. IlvC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A8AA38_IGNH4

Accession

Primary (citable) accession number: A8AA38

Entry history

Integrated into UniProtKB/TrEMBL:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	November 16, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)